Search Results - "BOTROUS IRINY" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

Structure Based Drug Design of Crizotinib (PF-02341066), a Potent and Selective Dual Inhibitor of Mesenchymal–Epithelial Transition Factor (c-MET) Kinase and Anaplastic Lymphoma Kinase (ALK)

by Cui, J. Jean, Tran-Dubé, Michelle, Shen, Hong, Nambu, Mitchell, Kung, Pei-Pei, Pairish, Mason, Jia, Lei, Meng, Jerry, Funk, Lee, Botrous, Iriny, McTigue, Michele, Grodsky, Neil, Ryan, Kevin, Padrique, Ellen, Alton, Gordon, Timofeevski, Sergei, Yamazaki, Shinji, Li, Qiuhua, Zou, Helen, Christensen, James, Mroczkowski, Barbara, Bender, Steve, Kania, Robert S, Edwards, Martin P
Published in Journal of medicinal chemistry (22.09.2011)

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Journal Article

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

by Dyck, Brian, Branstetter, Bryan, Gharbaoui, Tawfik, Hudson, Andrew R, Breitenbucher, J. Guy, Gomez, Laurent, Botrous, Iriny, Marrone, Tami, Barido, Richard, Allerston, Charles K, Cedervall, E. Peder, Xu, Rui, Sridhar, Vandana, Barker, Ryan, Aertgeerts, Kathleen, Schmelzer, Kara, Neul, David, Lee, Dong, Massari, Mark Eben, Andersen, Carsten B, Sebring, Kristen, Zhou, Xianbo, Petroski, Robert, Limberis, James, Augustin, Martin, Chun, Lawrence E, Edwards, Thomas E, Peters, Marco, Tabatabaei, Ali
Published in Journal of medicinal chemistry (27.04.2017)

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Journal Article

HSD17B13 억제제 및 이의 용도

HSD17B13 억제제 및 이의 용도

by GOVEK STEVEN P, NAGASAWA JOHNNY Y, HUDSON ANDREW R, BOTROUS IRINY, FASANYA KARENSA L, SMITH NICHOLAS D
Year of Publication 18.07.2023

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Patent

HSD17B13 억제제 및 이의 용도

HSD17B13 억제제 및 이의 용도

by GOVEK STEVEN P, NAGASAWA JOHNNY Y, HUDSON ANDREW R, BOTROUS IRINY, FASANYA KARENSA L, SMITH NICHOLAS D
Year of Publication 18.07.2023

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Patent

Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers

Abstract 4034: A potent and highly selective irreversible HER2 inhibitor for treating HER2-driven cancers

by Zhao, Chunmei, Kulyk, Lana, Botrous, Iriny, Chen, Kelly, Zhao, Chang, Banisadr, Afsheen, Anderson, Mary L., Manby, Fred, Miller, Tom, Zhang, Chao, Gomez, Laurent, Huang, Zhongdong
Published in Cancer research (Chicago, Ill.) (04.04.2023)

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Journal Article

Abstract 1980: Validation of a novel Type II HER2 inhibitor through preclinical studies across various cancer models

Abstract 1980: Validation of a novel Type II HER2 inhibitor through preclinical studies across various cancer models

by Kulyk, Lana, Chen, Kelly, Botrous, Iriny, Zhao, Chunmei, Zhao, Chang, Maestre, Michael, Wright, Shawn, Dennis, Joseph, Park, Jeeyoung, Adams, Abby, Derricotte, Wallace, Yost, Shane, Anderson, Mary L., Manby, Fred, Miller, Tom, Zhang, Chao, Gomez, Laurent, Huang, Zhongdong
Published in Cancer research (Chicago, Ill.) (22.03.2024)

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Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]pyrazines using catalytic Ag(I) and Au(III) salts

Improved cyclization conditions to prepare 6-substituted pyrazolo[1,5-a]pyridines and pyrazolo[1,5-a]pyrazines using catalytic Ag(I) and Au(III) salts

by Braganza, John F., Bernier, Louise, Botrous, Iriny, Collins, Michael R., Li, Baohua, McAlpine, Indrawan, Ninkovic, Sacha, Ren, Shijian, Sach, Neal, Tran-Dubé, Michelle, Zeng, Qingbin, Zheng, Baojiang
Published in Tetrahedron letters (14.10.2015)

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Journal Article

PDE1 억제제로서의 치환된 푸라노피리미딘 화합물

PDE1 억제제로서의 치환된 푸라노피리미딘 화합물

by CHUNG DEMICHAEL, BURNS AARON, TRAN JOE, DYCK BRIAN, KLEINKE ANDREW, RAFFAELE NICHOLAS, WEINHOUSE MICHAEL, KUMAR DANGE VIJAY, BOOKSER BRETT, BOTROUS IRINY, MCCARRICK MARGARET
Year of Publication 18.09.2020

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Patent

Correction to Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazin-6-yl)-1 H -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

Correction to Discovery of a Novel Class of Exquisitely Selective Mesenchymal-Epithelial Transition Factor (c-MET) Protein Kinase Inhibitors and Identification of the Clinical Candidate 2-(4-(1-(Quinolin-6-ylmethyl)-1 H -[1,2,3]triazolo[4,5- b ]pyrazin-6-yl)-1 H -pyrazol-1-yl)ethanol (PF-04217903) for the Treatment of Cancer

by Cui, J. Jean, McTigue, Michele, Nambu, Mitchell, Tran-Dubé, Michelle, Pairish, Mason, Shen, Hong, Jia, Lei, Cheng, Hengmiao, Hoffman, Jacqui, Le, Phuong, Jalaie, Mehran, Goetz, Gilles H., Koenig, Marcel, Vojkovsky, Tomas, Zhang, Fang-Jie, Do, Steven, Botrous, Iriny, Ryan, Kevin, Grodsky, Neil, Deng, Ya-li, Parker, Max, Timofeevski, Sergei, Murray, Brion W., Yamazaki, Shinji, Aguirre, Shirley, Li, Qiuhua, Zou, Helen, Christensen, James
Published in Journal of medicinal chemistry (26.11.2012)

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Journal Article

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors

Identification of novel pyrrolopyrazoles as protein kinase C β II inhibitors

by Li, Hui, Hong, Yufeng, Nukui, Seiji, Lou, Jihong, Johnson, Sarah, Scales, Stephanie, Botrous, Iriny, Tompkins, Eileen, Yin, Chunfeng, Zhou, Ru, He, Mingying, Jensen, Jordan, Bouzida, Djamal, Alton, Gordon, Lafontaine, Jennifer, Grant, Stephan
Published in Bioorganic & medicinal chemistry letters (01.01.2011)

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Journal Article

HSD17B13 INHIBITORS AND USES THEREOF

HSD17B13 INHIBITORS AND USES THEREOF

by NAGASAWA, Johnny, LAI, Andiliy, GOVEK, Steven, HUDSON, Andrew, BOTROUS, Iriny
Year of Publication 05.10.2023

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Patent

COMPOUNDS AND METHODS FOR MODULATING HER2

COMPOUNDS AND METHODS FOR MODULATING HER2

by DERRICOTTE, Wallace, KULYK, Svitlana, WRIGHT, Shawn, DENNIS, Joseph, GOMEZ, Laurent, BOTROUS, Iriny
Year of Publication 06.06.2024

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Patent

COMPOUNDS AND METHODS FOR MODULATING HER2

COMPOUNDS AND METHODS FOR MODULATING HER2

by DERRICOTTE, Wallace, KULYK, Svitlana, WRIGHT, Shawn, DENNIS, Joseph, GOMEZ, Laurent, BOTROUS, Iriny
Year of Publication 25.04.2024

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Patent

COMPOUNDS AND METHODS FOR MODULATING HER2

COMPOUNDS AND METHODS FOR MODULATING HER2

by DERRICOTTE, Wallace, KULYK, Svitlana, WRIGHT, Shawn, DENNIS, Joseph, GOMEZ, Laurent, BOTROUS, Iriny
Year of Publication 29.02.2024

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Patent

HSD17B13 INHIBITORS AND USES THEREOF

HSD17B13 INHIBITORS AND USES THEREOF

by Smith, Nicholas D, Govek, Steven P, Nagasawa, Johnny Y, Botrous, Iriny, Hudson, Andrew R, Fasanya, Karensa L
Year of Publication 14.03.2024

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Patent

HETEROCYCLIC KINASE INHIBITORS AND PRODUCTS AND USES THEREOF

HETEROCYCLIC KINASE INHIBITORS AND PRODUCTS AND USES THEREOF

by Lopez, Luis, Kasem, Michelle, Botrous, Iriny, Rowbottom, Martin W, Coburn, Craig
Year of Publication 30.03.2023

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Patent

HSD17B13 INHIBITORS AND USES THEREOF

HSD17B13 INHIBITORS AND USES THEREOF

by Smith, Nicholas D, Govek, Steven P, Nagasawa, Johnny Y, Botrous, Iriny, Hudson, Andrew R, Fasanya, Karensa L
Year of Publication 01.02.2024

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Patent

HSD17B13 INHIBITORS AND USES THEREOF

HSD17B13 INHIBITORS AND USES THEREOF

by HUDSON, Andrew R, SMITH, Nicholas D, GOVEK, Steven P, NAGASAWA, Johnny Y, FASANYA, Karensa L, BOTROUS, Iriny
Year of Publication 09.08.2023

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Patent

HSD17B13 INHIBITORS AND USES THEREOF

HSD17B13 INHIBITORS AND USES THEREOF

by HUDSON, Andrew R, SMITH, Nicholas D, GOVEK, Steven P, NAGASAWA, Johnny Y, FASANYA, Karensa L, BOTROUS, Iriny
Year of Publication 09.08.2023

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Patent

Substituted furanopyrimidine compounds as PDE1 inhibitors

Substituted furanopyrimidine compounds as PDE1 inhibitors

by Raffaele, Nicholas, Kleinke, Andrew, McCarrick, Margaret, Burns, Aaron, Weinhouse, Michael, Tran, Joe, Botrous, Iriny, Chung, DeMichael, Bookser, Brett, Kumar, Dange Vijay, Dyck, Brian
Year of Publication 11.06.2024

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Patent

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