Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α‑Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors
Etsè, Koffi Sénam, Dorosz, Jerzy, McLain Christensen, Katrine, Thomas, Jean-Yves, Botez Pop, Iuliana, Goffin, Eric, Colson, Thomas, Lestage, Pierre, Danober, Laurence, Pirotte, Bernard, Kastrup, Jette Sandholm, Francotte, Pierre
Published in ACS chemical neuroscience (21.07.2021)
Published in ACS chemical neuroscience (21.07.2021)
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Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces
Nørholm, Ann-Beth, Francotte, Pierre, Goffin, Eric, Botez, Iuliana, Danober, Laurence, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S, Olsen, Lars, Oostenbrink, Chris
Published in Journal of chemical information and modeling (22.12.2014)
Published in Journal of chemical information and modeling (22.12.2014)
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Targeting galectin-3 in inflammatory and fibrotic diseases
Bouffette, Selena, Botez, Iuliana, De Ceuninck, Frédéric
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2023)
Published in Trends in pharmacological sciences (Regular ed.) (01.08.2023)
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Access to Galectin3 Inhibitors from Chemoenzymatic Synthons
Dussouy, Christophe, Téletchéa, Stéphane, Lambert, Annie, Charlier, Cathy, Botez, Iuliana, de Ceuninck, Frédéric, Grandjean, Cyrille
Published in Journal of organic chemistry (17.11.2020)
Published in Journal of organic chemistry (17.11.2020)
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New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring
Goffin, Eric, Fraikin, Pierre, Abboud, Dayana, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Hanson, Julien, Danober, Laurence, Francotte, Pierre, Pirotte, Bernard
Published in European journal of medicinal chemistry (15.03.2023)
Published in European journal of medicinal chemistry (15.03.2023)
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Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis
Brebion, Franck, Gosmini, Romain, Deprez, Pierre, Varin, Marie, Peixoto, Christophe, Alvey, Luke, Jary, Hélène, Bienvenu, Natacha, Triballeau, Nicolas, Blanque, Roland, Cottereaux, Céline, Christophe, Thierry, Vandervoort, Nele, Mollat, Patrick, Touitou, Robert, Leonard, Philip, Ceuninck, Frédéric De, Botez, Iuliana, Monjardet, Alain, van der Aar, Ellen, Amantini, David
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Design, synthesis and biological evaluation of conformationnally-restricted analogues of E7010 as inhibitors of tubulin assembly (ITA) and vascular disrupting agents (VDA)
Prudhomme, Vassili, Cucca, Mélissa, Nauton, Lionel, Andrieu, Elsa, Fereyrolles, Mathilde, Lamoine, Sylvain, Michelin, Clément, Bennis, Khalil, Collin, Aurore, De Ceuninck, Frédéric, Botez, Iuliana, Mallet, Christophe, Ducki, Sylvie
Published in European journal of medicinal chemistry (15.12.2022)
Published in European journal of medicinal chemistry (15.12.2022)
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Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators
Francotte, Pierre, Bay, Yasmin, Goffin, Eric, Colson, Thomas, Lesenfants, Cindy, Dorosz, Jerzy, Laulumaa, Saara, Fraikin, Pierre, de Tullio, Pascal, Beaufour, Caroline, Botez, Iuliana, Pickering, Darryl S., Frydenvang, Karla, Danober, Laurence, Kristensen, Anders Skov, Kastrup, Jette Sandholm, Pirotte, Bernard
Published in European journal of medicinal chemistry (15.01.2024)
Published in European journal of medicinal chemistry (15.01.2024)
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새로운 거대고리 LRRK2 키나제 억제제
DENIS ALEXIS, BLOM PETRA MARCELLA, LAUGEOIS MAXIME, LE TIRAN ARNAUD, DAUGAN ALAIN, HOUSSEMAN CHRISTOPHER GAETAN, DUMOULIN AUDREY, CHRISTENSEN KENNETH, BOTEZ IULIANA, LAMOTTE YANN, FAUCHER NICOLAS
Year of Publication 10.01.2023
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Year of Publication 10.01.2023
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A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process
Petit, Laurent, Botez, Iuliana, Tizot, André, Zard, Samir Z.
Published in Tetrahedron letters (27.06.2012)
Published in Tetrahedron letters (27.06.2012)
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5-[-1--3--]--24- 5-[PIPERAZIN-1-YL-3-OXO-PROPYL]-IMIDAZOLIDINE-24-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS
JARY HELENE MARIE, AMANTINI DAVID, DEPREZ PIERRE MARC MARIE JOSEPH, DE CEUNINCK FREDERIC ANDRE, VARIN MARIE LAURENCE CLAIRE, POP BOTEZ IULIANA ECATERINA, PEIXOTO CHRISTOPHE, BREBION FRANCK LAURENT, ALVEY LUKE JONATHAN, GOSMINI ROMAIN LUC MARIE
Year of Publication 06.11.2017
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Year of Publication 06.11.2017
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New substituted aryl esters and aryl amides of 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors
Dintilhac, Gaëlle, Arslan, Deniz, Dilly, Sébastien, Danober, Laurence, Botez, Iuliana, Lestage, Pierre, Pirotte, Bernard, de Tullio, Pascal
Published in MedChemComm (01.06.2011)
Published in MedChemComm (01.06.2011)
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Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth, Francotte, Pierre, Olsen, Lars, Krintel, Christian, Frydenvang, Karla, Goffin, Eric, Challal, Sylvie, Danober, Laurence, Botez-Pop, Iuliana, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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Positive Allosteric Modulators of 2‑Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4‑Cyclopropyl-3,4-dihydro‑2H‑1,2,4-benzothiadiazine 1,1-Dioxides
Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S, Pirotte, Bernard
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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Synthesis, Pharmacological and Structural Characterization, and Thermodynamic Aspects of GluA2-Positive Allosteric Modulators with a 3,4-Dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxide Scaffold
Nørholm, Ann-Beth, Francotte, Pierre, Olsen, Lars, Krintel, Christian, Frydenvang, Karla, Goffin, Eric, Challal, Sylvie, Danober, Laurence, Botez-Pop, Iuliana, Lestage, Pierre, Pirotte, Bernard, Kastrup, Jette S.
Published in Journal of medicinal chemistry (14.11.2013)
Published in Journal of medicinal chemistry (14.11.2013)
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Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2 H -1,2,4-benzothiadiazine 1,1-Dioxides
Francotte, Pierre, Nørholm, Ann-Beth, Deva, Taru, Olsen, Lars, Frydenvang, Karla, Goffin, Eric, Fraikin, Pierre, de Tullio, Pascal, Challal, Sylvie, Thomas, Jean-Yves, Iop, Fabrice, Louis, Caroline, Botez-Pop, Iuliana, Lestage, Pierre, Danober, Laurence, Kastrup, Jette S., Pirotte, Bernard
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
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NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
BOTEZ, Iuliana, DUMOULIN, Audrey, BLOM, Petra Marcella, HOUSSEMAN, Christopher Gaètan, LE TIRAN, Arnaud, DENIS, Alexis, DAUGAN, Alain, CHRISTENSEN, Kenneth, LAUGEOIS, Maxime, LAMOTTE, Yann, FAUCHER, Nicolas
Year of Publication 09.11.2023
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Year of Publication 09.11.2023
Patent
NEW MACROCYCLIC LRRK2 KINASE INHIBITORS
HOUSSEMAN, Christopher Gaétan, BOTEZ, Iuliana, DUMOULIN, Audrey, BLOM, Petra Marcella, LE TIRAN, Arnaud, DENIS, Alexis, DAUGAN, Alain, CHRISTENSEN, Kenneth, LAUGEOIS, Maxime, LAMOTTE, Yann, FAUCHER, Nicolas
Year of Publication 15.03.2023
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Year of Publication 15.03.2023
Patent