The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Tam, Betty Y., Chiu, Kevin, Chung, Heekyung, Bossard, Carine, Nguyen, John Duc, Creger, Emily, Eastman, Brian W., Mak, Chi Ching, Ibanez, Maureen, Ghias, Abdullah, Cahiwat, Joseph, Do, Long, Cho, Shawn, Nguyen, Jackie, Deshmukh, Vishal, Stewart, Josh, Chen, Chiao-Wen, Barroga, Charlene, Dellamary, Luis, KC, Sunil K., Phalen, Timothy J., Hood, John, Cha, Steven, Yazici, Yusuf
Published in Cancer letters (31.03.2020)
Published in Cancer letters (31.03.2020)
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Journal Article
Potential role of estrogen receptor beta as a tumor suppressor of epithelial ovarian cancer
Bossard, Carine, Busson, Muriel, Vindrieux, David, Gaudin, Françoise, Machelon, Véronique, Brigitte, Madly, Jacquard, Carine, Pillon, Arnaud, Balaguer, Patrick, Balabanian, Karl, Lazennec, Gwendal
Published in PloS one (06.09.2012)
Published in PloS one (06.09.2012)
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Journal Article
Dimeric PKD regulates membrane fission to form transport carriers at the TGN
Bossard, Carine, Bresson, Damien, Polishchuk, Roman S, Malhotra, Vivek
Published in The Journal of cell biology (17.12.2007)
Published in The Journal of cell biology (17.12.2007)
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Journal Article
Protein kinase D regulates basolateral membrane protein exit from trans -Golgi network
Malhotra, Vivek, Yeaman, Charles, Ayala, M. Inmaculada, Wright, Jessica R, Bard, Frederic, Bossard, Carine, Ang, Agnes, Maeda, Yusuke, Seufferlein, Thomas, Mellman, Ira, Nelson, W. James
Published in Nature cell biology (01.02.2004)
Published in Nature cell biology (01.02.2004)
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Journal Article
Translokin is an intracellular mediator of FGF-2 trafficking
Prats, Hervé, Bossard, Carine, Laurell, Henrik, Van den Berghe, Loïc, Meunier, Sylvain, Zanibellato, Catherine
Published in Nature cell biology (01.05.2003)
Published in Nature cell biology (01.05.2003)
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Journal Article
Localization of the Discontinuous Immunodominant Region Recognized by Human Anti-thyroperoxidase Autoantibodies in Autoimmune Thyroid Diseases
Bresson, Damien, Cerutti, Martine, Devauchelle, Gérard, Pugnière, Martine, Roquet, Francoise, Bes, Cédric, Bossard, Carine, Chardès, Thierry, Péraldi-Roux, Sylvie
Published in The Journal of biological chemistry (14.03.2003)
Published in The Journal of biological chemistry (14.03.2003)
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Journal Article
890-P: Ultraselective DYRK1A/B Inhibitors Mediated ß-Cell Proliferation and Insulin Production In Vitro and In Vivo
Mittapalli, Gopi Kumar, Mak, Chi-Ching, Bossard, Carine, Vakiti, Ramkrishna Reddy, Creger, Emily, Gutierrez, Erik, Horsley, Erich A, Swearingen, Christopher, Hill, John S
Published in Diabetes (New York, N.Y.) (01.06.2024)
Published in Diabetes (New York, N.Y.) (01.06.2024)
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Journal Article
The Pan-Clk/Dyrk Inhibitor Cirtuvivint (SM08502) Exposes Mechanistic Underpinnings of Alternative Splicing As a Therapeutic Vulnerability in Heme Malignancies
Bossard, Carine, McMillan, Elizabeth A., Creger, Emily, Eastman, Brian, Mak, Chi-Ching, Beaupre, Darrin M., White, Michael A.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
CP110 Suppresses Primary Cilia Formation through Its Interaction with CEP290, a Protein Deficient in Human Ciliary Disease
Tsang, William Y., Bossard, Carine, Khanna, Hemant, Peränen, Johan, Swaroop, Anand, Malhotra, Vivek, Dynlacht, Brian David
Published in Developmental cell (01.08.2008)
Published in Developmental cell (01.08.2008)
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Journal Article
Abstract 3521: Transcriptome analysis of TCGA prostate cancer samples identifies an association of poorer survival and aggressive disease biology with CDC-like kinase (CLK) expression and spliceosome regulation
Cho, Shawn, Choudhury, Atish D., Fleener, Catherine, Do, Long, Bossard, Carine, Chung, Heekyung, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Modulation of RNA splicing enhances response to BCL2 inhibition in leukemia
Wang, Eric, Pineda, Jose Mario Bello, Kim, Won Jun, Chen, Sisi, Bourcier, Jessie, Stahl, Maximilian, Hogg, Simon J., Bewersdorf, Jan Phillipp, Han, Cuijuan, Singer, Michael E., Cui, Daniel, Erickson, Caroline E., Tittley, Steven M., Penson, Alexander V., Knorr, Katherine, Stanley, Robert F., Rahman, Jahan, Krishnamoorthy, Gnana, Fagin, James A., Creger, Emily, McMillan, Elizabeth, Mak, Chi-Ching, Jarvis, Matthew, Bossard, Carine, Beaupre, Darrin M., Bradley, Robert K., Abdel-Wahab, Omar
Published in Cancer cell (09.01.2023)
Published in Cancer cell (09.01.2023)
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Journal Article
Alternative splicing (AS) regulation as a novel therapeutic target in soft-tissue sarcoma (STS)
Moura, David Silva, Martinez-Font, Esther, Bossard, Carine, Rubio-Reyes, Antonio, Mondaza-Hernandez, Jose Lucinio, Martin-Ruiz, Marta, Romero-Gonzalez, Pablo, Renshaw-Calderon, Marta, Carrillo-Garcia, Jaime, Di Lernia, Davide, Hindi, Nadia, Obrador, Antonia, Martin Broto, Javier
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Abstract P231: Multigenomic characterization of context-dependent alternative splicing in normal and neoplastic cells
McMillan, Elizabeth A., Sriram, Krishna, Creger, Emily, Merkwirth, Carsten, Pippa, Raffaella, Pedraza, Melinda, Do, Long, Deshmukh, Vishal, Bossard, Carine, White, Michael A.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract P250: Evaluation of systemic pan-CLK/DYRK inhibition on organ function and tissue self-renewal
Falahatpisheh, Hadi, Dehghani, Maryam, Morrow, Jane, Tsao, Catherine, Dorrow, Steven, Stewart, Josh, Bossard, Carine, Eastman, Brian, Mak, Chi-Ching, Pandher, Karamjeet, White, Michael A.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract P242: Preclinical efficacy landscape of the pan-CLK/DYRK inhibitor Cirtuvivint (SM08502)
Bossard, Carine, Creger, Emily, McMillan, Elizabeth A., Merkwirth, Carsten, Ibanez, Maureen, Bhat, Deepti, Stewart, Josh, Eastman, Brian, Mak, Chi-Ching, Deshmukh, Vishal, White, Michael A.
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
Abstract C08: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates activity against cancer stem cell (CSC)-enriched pancreatic cancer cells and suppresses stemness in vitro
Bossard, Carine, Cruz, Nathalia, Eastman, Brian, Mak, Chi-Ching, KC, Sunil, Tam, Betty, Phalen, Timothy, Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.12.2019)
Published in Cancer research (Chicago, Ill.) (15.12.2019)
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Journal Article
Abstract 6401: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt and cyclin D-CDK4/6-RB pathway inhibition in hormone-receptor-positive (HR+) breast cancer models
Chung, Heekyung, Sitts, Lauren, Wu, Chu-Chiao, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Stewart, Josh, Bossard, Carine, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Abstract 5691: SM08502, a novel, small-molecule CDC-like kinase (CLK) inhibitor, demonstrates strong antitumor effects and Wnt pathway inhibition in castration-resistant prostate cancer (CRPC) models
Bossard, Carine, Cruz, Nathalia, Chiu, Kevin, Eastman, Brian, Mak, Chi Ching, KC, Sunil, Bucci, Gail, Stewart, Josh, Phalen, Timothy J., Cha, Steven
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Modulation of RNA Splicing Enhances Response to BCL2 Inhibition in Acute Myeloid Leukemia
Wang, Eric, Bello Pineda, Jose Mario, Bourcier, Jessie, Stahl, Maximilian, Penson, Alexander V, Wakiro, Isaac, Singer, Michael E, Cui, Daniel, Erickson, Caroline, Knorr, Katherine, Stanley, Robert, Chen, Xufeng, McMillan, Elizabeth A., Bossard, Carine, Aifantis, Iannis, Bradley, Robert K., Abdel-Wahab, Omar
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article