Search Results - "BORITZKI, Theodore" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

Novel Tricyclic Poly(ADP-ribose) Polymerase-1 Inhibitors with Potent Anticancer Chemopotentiating Activity: Design, Synthesis, and X-ray Cocrystal Structure

by Canan Koch, Stacie S, Thoresen, Lars H, Tikhe, Jayashree G, Maegley, Karen A, Almassy, Robert J, Li, Jianke, Yu, Xiao-Hong, Zook, Scott E, Kumpf, Robert A, Zhang, Cathy, Boritzki, Theodore J, Mansour, Rena N, Zhang, Kanyin E, Ekker, Anne, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R, Webber, Stephen E, Hostomsky, Zdenek
Published in Journal of medicinal chemistry (07.11.2002)

Get full text

Journal Article

Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Design, Synthesis, and Evaluation of 3,4-Dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

by Tikhe, Jayashree G, Webber, Stephen E, Hostomsky, Zdenek, Maegley, Karen A, Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J, Kumpf, Robert A, Boritzki, Theodore J, Zhang, Cathy, Calabrese, Chris R, Curtin, Nicola J, Kyle, Suzanne, Thomas, Huw D, Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T, Griffin, Roger J, Newell, David R
Published in Journal of medicinal chemistry (21.10.2004)

Get full text

Journal Article

Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation

Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: The critical role of polyglutamylation

by FAESSEL, H. M, SLOCUM, H. K, JACKSON, R. C, BORITZKI, T. J, RUSTUM, Y. M, NAIR, M. G, GRECO, W. R
Published in Cancer research (Chicago, Ill.) (15.07.1998)

Get full text

Journal Article

DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard

DNA-directed alkylating agents. 1. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the reactivity of the mustard

by Gourdie, Trudi A, Valu, Kisione K, Gravatt, G. Lance, Boritzki, Theodore J, Baguley, Bruce C, Wakelin, Laurence P. G, Wilson, William R, Woodgate, Paul D, Denny, William A
Published in Journal of medicinal chemistry (01.04.1990)

Get full text

Journal Article

DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain

DNA-directed alkylating agents. 3. Structure-activity relationships for acridine-linked aniline mustards: consequences of varying the length of the linker chain

by Valu, Kisione K, Gourdie, Trudi A, Boritzki, Theodore J, Gravatt, G. Lance, Baguley, Bruce C, Wilson, William R, Wakelin, Laurence P. G, Woodgate, Paul D, Denny, William A
Published in Journal of medicinal chemistry (01.11.1990)

Get full text

Journal Article

Identification of the major lesion from the reaction of an acridine targeted aniline mustard with DNA as an adenine N1 adduct

Identification of the major lesion from the reaction of an acridine targeted aniline mustard with DNA as an adenine N1 adduct

by Boritzki, Theodore J, Palmer, Brian D, Coddington, Jan M, Denny, William A
Published in Chemical research in toxicology (01.01.1994)

Get full text

Journal Article

Inhibition of type II topoisomerase by fostriecin

Inhibition of type II topoisomerase by fostriecin

by Boritzki, T J, Wolfard, T S, Besserer, J A, Jackson, R C, Fry, D W
Published in Biochemical pharmacology (01.11.1988)

Get more information

Journal Article

SYNTHESIS AND BIOLOGICAL EVALUATION OF N-[4-(2-TRANS-[([2,6-DIAMINO-4(3H)-OXOPYRIMIDIN-5-YL]METHYL)THIO]CYCLOBUTYL)BENZOYL]-L-GLUTAMIC ACID A NOVEL 5-THIAPYRIMIDINONE INHIBITOR OF DIHYDROFOLATE-REDUCTASE

SYNTHESIS AND BIOLOGICAL EVALUATION OF N-[4-(2-TRANS-[([2,6-DIAMINO-4(3H)-OXOPYRIMIDIN-5-YL]METHYL)THIO]CYCLOBUTYL)BENZOYL]-L-GLUTAMIC ACID A NOVEL 5-THIAPYRIMIDINONE INHIBITOR OF DIHYDROFOLATE-REDUCTASE

by VARNEY, MD, ROMINES, WH, BORITZKI, T, MARGOSIAK, SA, BARTLETT, C, HOWLAND, EJ
Published in Journal of heterocyclic chemistry (01.09.1995)

Get more information

Journal Article

Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies

Identification of potent nontoxic poly(ADP-ribose) polymerase-1 inhibitors: Chemopotentiation and pharmacological studies

by CALABRESE, Christopher R, BATEY, Michael A, MAEGLEY, Karen, CALVERT, Alan H, HOSTOMSKY, Zdenek, NEWELL, David R, CURTIN, Nicola J, THOMAS, Huw D, DURKACZ, Barbara W, WANG, Lan-Zhen, KYLE, Suzanne, SKALITZKY, Donald, LI, Janke, ZHANG, Catherine, BORITZKI, Theodore
Published in Clinical cancer research (01.07.2003)

Get full text

Journal Article

Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats

Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats

by Jackson, R C, Lui, M S, Boritzki, T J, Morris, H P, Weber, G
Published in Cancer research (Chicago, Ill.) (01.04.1980)

Get full text

Journal Article

An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint

An inhibitor of glycinamide ribonucleotide formyltransferase is selectively cytotoxic to cells that lack a functional G1 checkpoint

by Zhang, Cathy C., Boritzki, Theodore J., Jackson, Robert C.
Published in Cancer chemotherapy and pharmacology (09.12.1997)

Get full text

Journal Article

Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

Design, Synthesis, and Evaluation of 3,4-Dihydro-2 H -[1,4]diazepino[6,7,1- hi ]indol-1-ones as Inhibitors of Poly(ADP-Ribose) Polymerase

by Tikhe, Jayashree G., Webber, Stephen E., Hostomsky, Zdenek, Maegley, Karen A., Ekkers, Anne, Li, Jianke, Yu, Xiao-Hong, Almassy, Robert J., Kumpf, Robert A., Boritzki, Theodore J., Zhang, Cathy, Calabrese, Chris R., Curtin, Nicola J., Kyle, Suzanne, Thomas, Huw D., Wang, Lan-Zhen, Calvert, A. Hilary, Golding, Bernard T., Griffin, Roger J., Newell, David R.
Published in Journal of medicinal chemistry (01.10.2004)

Get full text

Journal Article

Identification of Potent Nontoxic Poly(ADP-Ribose) Polymerase-1 Inhibitors

Identification of Potent Nontoxic Poly(ADP-Ribose) Polymerase-1 Inhibitors

by Christopher R. Calabrese, Michael A. Batey, Huw D. Thomas, Barbara W. Durkacz, Lan-Zhen Wang, Suzanne Kyle, Donald Skalitzky, Janke Li, Catherine Zhang, Theodore Boritzki, Karen Maegley, Alan H. Calvert, Zdenek Hostomsky, David R. Newell, Nicola J. Curtin
Published in Clinical cancer research (01.07.2003)

Get full text

Journal Article

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies

by Webber, S, Bartlett, C A, Boritzki, T J, Hillard, J A, Howland, E F, Johnston, A L, Kosa, M, Margosiak, S A, Morse, C A, Shetty, B V
Published in Cancer chemotherapy and pharmacology (1996)

Get more information

Journal Article

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition

Protein Structure-Based Design, Synthesis, and Biological Evaluation of 5-Thia-2,6-diamino-4(3H)-oxopyrimidines: Potent Inhibitors of Glycinamide Ribonucleotide Transformylase with Potent Cell Growth Inhibition

by Varney, Michael D, Palmer, Cindy L, Romines, William H, Boritzki, Theodore, Margosiak, Stephen A, Almassy, Robert, Janson, Cheryl A, Bartlett, Charlotte, Howland, Eleanor J, Ferre, Rosanne
Published in Journal of medicinal chemistry (01.08.1997)

Get full text

Journal Article

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

AG2034: a novel inhibitor of glycinamide ribonucleotide formyltransferase

by Boritzki, T J, Barlett, C A, Zhang, C, Howland, E F
Published in Investigational new drugs (01.01.1996)

Get more information

Journal Article

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

Biochemical pharmacology of the lipophilic antifolate, trimetrexate

by Jackson, Robert C., Fry, David W., Boritzki, Theodore J., Besserer, Judith A., Leopold, Wilbur R., Sloan, Bernard J., Elslager, Edward F.
Published in Advances in enzyme regulation (1984)

Get full text

Journal Article

Transport of the antitumor antibiotic CI-920 into L1210 leukemia cells by the reduced folate carrier system

Transport of the antitumor antibiotic CI-920 into L1210 leukemia cells by the reduced folate carrier system

by FRY, D. W, BESSERER, J. A, BORITZKI, T. J
Published in Cancer research (Chicago, Ill.) (01.08.1984)

Get full text

Journal Article

In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles)

In vitro DNA strand scission and inhibition of nucleic acid synthesis in L1210 leukemia cells by a new class of DNA complexers, the anthra[1,9-cd]pyrazol-6(2H)-ones (anthrapyrazoles)

by Fry, D W, Boritzki, T J, Besserer, J A, Jackson, R C
Published in Biochemical pharmacology (01.10.1985)

Get more information

Journal Article

Biochemical and antitumor activity of tiazofurin and its selenium analog (2-beta-D-ribofuranosyl-4-selenazolecarboxamide)

Biochemical and antitumor activity of tiazofurin and its selenium analog (2-beta-D-ribofuranosyl-4-selenazolecarboxamide)

by Boritzki, T J, Berry, D A, Besserer, J A, Cook, P D, Fry, D W, Leopold, W R, Jackson, R C
Published in Biochemical pharmacology (01.04.1985)

Get more information

Journal Article