Pathway and mechanism of drug binding to G-protein-coupled receptors
Dror, Ron O, Pan, Albert C, Arlow, Daniel H, Borhani, David W, Maragakis, Paul, Shan, Yibing, Xu, Huafeng, Shaw, David E
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (09.08.2011)
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Journal Article
The future of molecular dynamics simulations in drug discovery
Borhani, David W., Shaw, David E.
Published in Journal of computer-aided molecular design (01.01.2012)
Published in Journal of computer-aided molecular design (01.01.2012)
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Journal Article
Molecular determinants of drug–receptor binding kinetics
Pan, Albert C., Borhani, David W., Dror, Ron O., Shaw, David E.
Published in Drug discovery today (01.07.2013)
Published in Drug discovery today (01.07.2013)
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Journal Article
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs
Dror, Ron O., Green, Hillary F., Valant, Celine, Borhani, David W., Valcourt, James R., Pan, Albert C., Arlow, Daniel H., Canals, Meritxell, Lane, J. Robert, Rahmani, Raphaël, Baell, Jonathan B., Sexton, Patrick M., Christopoulos, Arthur, Shaw, David E.
Published in Nature (London) (14.11.2013)
Published in Nature (London) (14.11.2013)
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Journal Article
Structural basis for nucleotide exchange in heterotrimeric G proteins
Dror, Ron O., Mildorf, Thomas J., Hilger, Daniel, Manglik, Aashish, Borhani, David W., Arlow, Daniel H., Philippsen, Ansgar, Villanueva, Nicolas, Yang, Zhongyu, Lerch, Michael T., Hubbell, Wayne L., Kobilka, Brian K., Sunahara, Roger K., Shaw, David E.
Published in Science (American Association for the Advancement of Science) (19.06.2015)
Published in Science (American Association for the Advancement of Science) (19.06.2015)
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Journal Article
Principles of conduction and hydrophobic gating in K⁺ channels
Jensen, Morten Ø, Borhani, David W, Lindorff-Larsen, Kresten, Maragakis, Paul, Jogini, Vishwanath, Eastwood, Michael P, Dror, Ron O, Shaw, David E
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (30.03.2010)
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Journal Article
Dynamic control of slow water transport by aquaporin 0: Implications for hydration and junction stability in the eye lens
Jensen, Morten Ø, Dror, Ron O, Xu, Huafeng, Borhani, David W, Arkin, Isaiah T, Eastwood, Michael P, Shaw, David E
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (23.09.2008)
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Journal Article
Rethinking Clinical Trials: Biology's Mysteries
BORHANI, DAVID W., BUTTS, J. ADAM
Published in Science (American Association for the Advancement of Science) (09.12.2011)
Published in Science (American Association for the Advancement of Science) (09.12.2011)
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Journal Article
Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation
Reynolds, Robert C, Campbell, Shiela R, Fairchild, Ralph G, Kisliuk, Roy L, Micca, Peggy L, Queener, Sherry F, Riordan, James M, Sedwick, W. David, Waud, William R, Leung, Dixon, Richard W, Suling, William J, Borhani, David W
Published in Journal of medicinal chemistry (12.07.2007)
Published in Journal of medicinal chemistry (12.07.2007)
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Journal Article
Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases
Comess, Kenneth M, Sun, Chaohong, Abad-Zapatero, Cele, Goedken, Eric R, Gum, Rebecca J, Borhani, David W, Argiriadi, Maria, Groebe, Duncan R, Jia, Yong, Clampit, Jill E, Haasch, Deanna L, Smith, Harriet T, Wang, Sanyi, Song, Danying, Coen, Michael L, Cloutier, Timothy E, Tang, Hua, Cheng, Xueheng, Quinn, Christopher, Liu, Bo, Xin, Zhili, Liu, Gang, Fry, Elizabeth H, Stoll, Vincent, Ng, Teresa I, Banach, David, Marcotte, Doug, Burns, David J, Calderwood, David J, Hajduk, Philip J
Published in ACS chemical biology (18.03.2011)
Published in ACS chemical biology (18.03.2011)
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Journal Article
Structure of Mycobacterium tuberculosis FtsZ Reveals Unexpected, G Protein-like Conformational Switches
Leung, Adelaine K.W., Lucile White, E., Ross, Larry J., Reynolds, Robert C., DeVito, Joseph A., Borhani, David W.
Published in Journal of molecular biology (17.09.2004)
Published in Journal of molecular biology (17.09.2004)
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Journal Article
Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor
Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V
Published in BMC structural biology (20.09.2012)
Published in BMC structural biology (20.09.2012)
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Journal Article
Activation mechanism of the β2-adrenergic receptor
Dror, Ron O, Arlow, Daniel H, Maragakis, Paul, Mildorf, Thomas J, Pan, Albert C, Xu, Huafeng, Borhani, David W, Shaw, David E
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2011)
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Journal Article