BH3 Domains of BH3-Only Proteins Differentially Regulate Bax-Mediated Mitochondrial Membrane Permeabilization Both Directly and Indirectly
Kuwana, Tomomi, Bouchier-Hayes, Lisa, Chipuk, Jerry E., Bonzon, Christine, Sullivan, Barbara A., Green, Douglas R., Newmeyer, Donald D.
Published in Molecular cell (18.02.2005)
Published in Molecular cell (18.02.2005)
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Journal Article
Abstract 5549: Potency-reduced IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity
Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R., Bernett, Matthew J.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Journal Article
Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy
Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal
Published in Frontiers in pharmacology (03.06.2024)
Published in Frontiers in pharmacology (03.06.2024)
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Journal Article
The Multidomain Proapoptotic Molecules Bax and Bak Are Directly Activated by Heat
Lisa J. Pagliari, Kuwana, Tomomi, Christine Bonzon, Newmeyer, Donald D., Shine Tu, Helen M. Beere, Green, Douglas R.
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (13.12.2005)
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1060 Optimally engineered IL18 Fc-fusion proteins balance potency and pharmacokinetics to promote strong anti-tumor activity
Nisthal, Alex, Lee, Sung-Hyung, Bonzon, Christine, Love, Ruschelle, Avery, Kendra N, Rashid, Rumana, Lertkiatmongkol, Panida, Rodriguez, Nicole, Leung, Irene, Karki, Sher, Barlow, Norman J, Chu, Seung Y, Moore, Gregory L, Desjarlais, John R
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Inhibition of B cell activation following in vivo co-engagement of B cell antigen receptor and Fcγ receptor IIb in non-autoimmune-prone and SLE-prone mice
Chu, Seung Y., Pong, Erik, Bonzon, Christine, Yu, Ning, Jacob, Chaim O., Chalmers, Samantha A., Putterman, Chaim, Szymkowski, David E., Stohl, William
Published in Journal of translational autoimmunity (Online) (01.01.2021)
Published in Journal of translational autoimmunity (Online) (01.01.2021)
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1193 Synergistic targeting of multiple activating pathways with natural killer cell engagers
Zhang, Tian, Faber, Matthew S, Pong, Erik, Liu, Ke, Kim, Nahee, Bernett, Matthew J, Bonzon, Christine, Wieler, James, Diaz, Juan E, Avery, Kendra N, Henderson, Elizabeth, Yeh, William Y, Qi, Jing, Hao, Su-Shin, Rashid, Rumana, Bahjat, Rena, Desjarlais, John R, Bykova, Katrina
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
698 PD-L1 targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Zeng, Veronica, Moore, Gregory, Diaz, Juan, Bonzon, Christine, Avery, Kendra, Love, Ruschelle, Dragovich, Matthew, Rashid, Rumana, Leung, Irene, Hackett, Michael, Qi, Jing, Bakhit, Charles, Muchhal, Umesh, Barlow, Norman, Desjarlais, John, Hedvat, Michael
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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787 Natural killer cell engagers activate innate and adaptive immunity and show synergy with proinflammatory cytokines
Bykova, Katrina, Faber, Matthew, Liu, Ke, Siddiqi, Noor, Bernett, Matthew, Bonzon, Christine, Diaz, Juan, Nam, Dong Hyun, Avery, Kendra, Qi, Jing, Rashid, Rumana, Bahjat, Rena, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Journal Article
697 Tumor-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Hedvat, Michael, Zeng, Veronica, Diaz, Juan, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Leung, Irene, Bartlow, Norm, Bakhit, Charles, Dragovich, Matthew, Bogart, Liz, Muchhal, Umesh, Desjarlais, John, Moore, Gregory
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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714 PD1 x TGFβR2 bispecifics selectively block TGFβR2 on PD1-positive T cells, promote T cell activation, and elicit an anti-tumor response in solid tumors
Moore, Gregory, Schubbert, Suzanne, Bonzon, Christine, Avery, Kendra, Rashid, Rumana, Pong, Erik, Ochyl, Lukasz, Nisthal, Alex, Chu, Seung, Ernst, James, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents
Bernett, Matthew, Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung, Muchhal, Umesh, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Journal Article
Mitochondrial Release of Pro-apoptotic Proteins
Uren, Rachel T., Dewson, Grant, Bonzon, Christine, Lithgow, Trevor, Newmeyer, Donald D., Kluck, Ruth M.
Published in The Journal of biological chemistry (21.01.2005)
Published in The Journal of biological chemistry (21.01.2005)
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Journal Article
IL15/IL15R Fc- IL15/IL15R HETERODIMERIC FC-FUSION PROTEINS
VARMA RAJAT, BONZON CHRISTINE, DESJARLAIS JOHN, RASHID RUMANA, BERNETT MATTHEW
Year of Publication 22.03.2024
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Year of Publication 22.03.2024
Patent
A B7-H3-targeted CD28 bispecific antibody enhances the activity of anti-PD1 and CD3 T-cell engager immunotherapies
Moore, Gregory L, Zeng, Veronica G, Diaz, Juan E, Bonzon, Christine, Avery, Kendra N, Rashid, Rumana, Qi, Jing, Nam, Dong Hyun, Jacinto, Jonathan, Dragovich, Matthew A, Kim, Yoon Kyung, Balcazar, Karen P, Bakhit, Charles G, Eivazi, Araz, Nguyen, Hanh, Muchhal, Umesh S, Szymkowski, David E, Desjarlais, John R, Hedvat, Michael
Published in Molecular cancer therapeutics (20.09.2024)
Published in Molecular cancer therapeutics (20.09.2024)
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Journal Article
Abstract 1880: PDL1-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors
Moore, Gregory L., Zeng, Veronica, Diaz, Juan, Bonzon, Christine, Avery, Kendra N., Love, Ruschelle, Dragovich, Matthew, Rashid, Rumana, Hackett, Michael, Leung, Irene W., Qi, Jing, Bakhit, Charles G., Muchhal, Umesh S., Barlow, Norman J., Desjarlais, John R., Hedvat, Michael
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 1743: IL12 heterodimeric Fc-fusions engineered for reduced potency exhibit strong anti-tumor activity and improved therapeutic index compared to native IL12 agents
Bernett, Matthew J., Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Bykova, Katrina, Hackett, Michael, Barlow, Norm, Leung, Irene, Nguyen, Duc-Hanh, Eivazi, Araz, Chu, Seung Y., Varma, Rajat, Muchhal, Umesh S., Desjarlais, John R.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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