MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies
Liu, Liqin, Lam, Chia-Ying K, Long, Vatana, Widjaja, Lusiana, Yang, Yinhua, Li, Hua, Jin, Linda, Burke, Steve, Gorlatov, Sergey, Brown, Jennifer, Alderson, Ralph, Lewis, Margaret D, Nordstrom, Jeffrey L, Koenig, Scott, Moore, Paul A, Johnson, Syd, Bonvini, Ezio
Published in Clinical cancer research (15.03.2017)
Published in Clinical cancer research (15.03.2017)
Get full text
Journal Article
Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer
Scribner, Juniper A, Brown, Jennifer G, Son, Thomas, Chiechi, Michael, Li, Pam, Sharma, Sharad, Li, Hua, De Costa, Anushka, Li, Ying, Chen, Yan, Easton, Ann, Yee-Toy, Nicholas C, Chen, Francine Z, Gorlatov, Sergey, Barat, Bhaswati, Huang, Ling, Wolff, Christina R, Hooley, Jeff, Hotaling, Tim E, Gaynutdinov, Timur, Ciccarone, Valentina, Tamura, James, Koenig, Scott, Moore, Paul A, Bonvini, Ezio, Loo, Deryk
Published in Molecular cancer therapeutics (01.11.2020)
Published in Molecular cancer therapeutics (01.11.2020)
Get full text
Journal Article
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial
Sherry, Nicole, Dr, Hagopian, William, MD, Ludvigsson, Johnny, Prof, Jain, Sunil M, MD, Wahlen, Jack, MD, Ferry, Robert J, Prof, Bode, Bruce, MD, Aronoff, Stephen, MD, Holland, Christopher, MS, Carlin, David, PhD, King, Karen L, MS, Wilder, Ronald L, MD, Pillemer, Stanley, MD, Bonvini, Ezio, MD, Johnson, Syd, PhD, Stein, Kathryn E, PhD, Koenig, Scott, MD, Herold, Kevan C, Prof, Daifotis, Anastasia G, MD
Published in The Lancet (British edition) (2011)
Published in The Lancet (British edition) (2011)
Get full text
Journal Article
Development of MGD007, a gpA33 x CD3-Bispecific DART Protein for T-Cell Immunotherapy of Metastatic Colorectal Cancer
Moore, Paul A, Shah, Kalpana, Yang, Yinhua, Alderson, Ralph, Roberts, Penny, Long, Vatana, Liu, Daorong, Li, Jonathan C, Burke, Steve, Ciccarone, Valentina, Li, Hua, Fieger, Claudia B, Hooley, Jeff, Easton, Ann, Licea, Monica, Gorlatov, Sergey, King, Kathy L, Young, Peter, Adami, Arash, Loo, Deryk, Chichili, Gurunadh R, Liu, Liqin, Smith, Douglas H, Brown, Jennifer G, Chen, Francine Z, Koenig, Scott, Mather, Jennie, Bonvini, Ezio, Johnson, Syd
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
Get full text
Journal Article
Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial
Aggarwal, Charu, Prawira, Amy, Antonia, Scott, Rahma, Osama, Tolcher, Anthony, Cohen, Roger B, Lou, Yanyan, Hauke, Ralph, Vogelzang, Nicholas, P Zandberg, Dan, Kalebasty, Arash Rezazadeh, Atkinson, Victoria, Adjei, Alex A, Seetharam, Mahesh, Birnbaum, Ariel, Weickhardt, Andrew, Ganju, Vinod, Joshua, Anthony M, Cavallo, Rosetta, Peng, Linda, Zhang, Xiaoyu, Kaul, Sanjeev, Baughman, Jan, Bonvini, Ezio, Moore, Paul A, Goldberg, Stacie M, Arnaldez, Fernanda I, Ferris, Robert L, Lakhani, Nehal J
Published in Journal for immunotherapy of cancer (01.04.2022)
Published in Journal for immunotherapy of cancer (01.04.2022)
Get full text
Journal Article
A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy
Crespo, Joel, Koh, Yi Ting, Hu, Ningjie, Moore, Paul A, Bonvini, Ezio, Glasebrook, Andrew L, Martin, Andrea P, Benschop, Robert J
Published in PloS one (17.02.2021)
Published in PloS one (17.02.2021)
Get full text
Journal Article
Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule
Berezhnoy, Alexey, Sumrow, Bradley J., Stahl, Kurt, Shah, Kalpana, Liu, Daorong, Li, Jonathan, Hao, Su-Shin, De Costa, Anushka, Kaul, Sanjeev, Bendell, Johanna, Cote, Gregory M., Luke, Jason J., Sanborn, Rachel E., Sharma, Manish R., Chen, Francine, Li, Hua, Diedrich, Gundo, Bonvini, Ezio, Moore, Paul A.
Published in Cell reports. Medicine (22.12.2020)
Published in Cell reports. Medicine (22.12.2020)
Get full text
Journal Article
Antitumor activity of the investigational B7-H3 antibody-drug conjugate, vobramitamab duocarmazine, in preclinical models of neuroblastoma
Brignole, Chiara, Calarco, Enzo, Bensa, Veronica, Giusto, Elena, Perri, Patrizia, Ciampi, Eleonora, Corrias, Maria Valeria, Astigiano, Simonetta, Cilli, Michele, Loo, Derik, Bonvini, Ezio, Pastorino, Fabio, Ponzoni, Mirco
Published in Journal for immunotherapy of cancer (01.09.2023)
Published in Journal for immunotherapy of cancer (01.09.2023)
Get full text
Journal Article
Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia
Barwe, Sonali P, Kisielewski, Anne, Bonvini, Ezio, Muth, John, Davidson-Moncada, Jan, Kolb, Edward Anders, Gopalakrishnapillai, Anilkumar
Published in Journal of clinical medicine (28.02.2022)
Published in Journal of clinical medicine (28.02.2022)
Get full text
Journal Article
Selective Blockade of Inhibitory Fcγ Receptor Enables Human Dendritic Cell Maturation with IL-12p70 Production and Immunity to Antibody-Coated Tumor Cells
Dhodapkar, Kavita M., Kaufman, Jacob L., Ehlers, Marc, Banerjee, Devi K., Bonvini, Ezio, Koenig, Scott, Steinman, Ralph M., Ravetch, Jeffrey V., Dhodapkar, Madhav V.
Published in Proceedings of the National Academy of Sciences - PNAS (22.02.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (22.02.2005)
Get full text
Journal Article
Abstract 1533: IMGC936, a first-in-class ADAM9-targeting antibody-drug conjugate, demonstrates promising anti-tumor activity
Hicks, Stuart, Loo, Deryk, Sinkevicius, Kerstin, Scribner, Juniper, Barat, Bhaswati, Yoder, Nicholas, Espelin, Christopher, Themeles, Marian, Chen, Francine, Lucas, Jacquelynn, Brown, Jennifer, Matin, Bahar, Fuller, Megan, Lee, Jenny, Salomon, Paulin, Costoplus, Juliet, Yancey, Sadiqa, Diedrich, Gundo, Gorlatov, Sergey, Son, Thomas, Chiechi, Michael, Li, Pam, Spliedt, Michael, Ciccarone, Valentina, Hooley, Jeff, Gantt, Nadia, Tamura, James, Donahue, Kerry, Moore, Paul, Johnson, Syd, Chittenden, Thomas, Gregory, Richard, Bonvini, Ezio
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Isolation of cancer stem like cells from human adenosquamous carcinoma of the lung supports a monoclonal origin from a multipotential tissue stem cell
Mather, Jennie P, Roberts, Penelope E, Pan, Zhuangyu, Chen, Francine, Hooley, Jeffrey, Young, Peter, Xu, Xiaolin, Smith, Douglas H, Easton, Ann, Li, Panjing, Bonvini, Ezio, Koenig, Scott, Moore, Paul A
Published in PloS one (04.12.2013)
Published in PloS one (04.12.2013)
Get full text
Journal Article
Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms
Circosta, Paola, Elia, Angela Rita, Landra, Indira, Machiorlatti, Rodolfo, Todaro, Maria, Aliberti, Sabrina, Brusa, Davide, Deaglio, Silvia, Chiaretti, Sabina, Bruna, Riccardo, Gottardi, Daniela, Massaia, Massimo, Giacomo, Filomena Di, Guarini, Anna Rita, Foà, Robin, Kyriakides, Peter W., Bareja, Rohan, Elemento, Olivier, Chichili, Gurunadh R., Monteleone, Emanuele, Moore, Paul A., Johnson, Syd, Bonvini, Ezio, Cignetti, Alessandro, Inghirami, Giorgio
Published in Oncoimmunology (03.04.2018)
Published in Oncoimmunology (03.04.2018)
Get full text
Journal Article
682 Antibody-mediated blockade of interleukin-10 receptor-alpha promotes the activation of immune cells from in vitro dissociated tumor samples
Berezhnoy, Alexey, Shah, Kalpana, Liu, Daorong, Lung, Peter, Long, Vatana, Stahl, Kurt, Smith, Douglas, Chen, Francine, Li, Hua, Li, Jonathan, Alderson, Ralph, Ciccarone, Valentina, Tamura, James, Bonvini, Ezio, Diedrich, Gundo, Moore, Paul
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
Get full text
Journal Article
Intramolecular Regulation of Phospholipase C-γ1 by Its C-Terminal Src Homology 2 Domain
DeBell, Karen, Graham, Laurie, Reischl, Ilona, Serrano, Carmen, Bonvini, Ezio, Rellahan, Barbara
Published in Molecular and Cellular Biology (01.02.2007)
Published in Molecular and Cellular Biology (01.02.2007)
Get full text
Journal Article
Notch-1 Controls the Expression of Fatty Acid-activated Transcription Factors and Is Required for Adipogenesis
Garcés, Carmen, Ruiz-Hidalgo, M.J., de Mora, Jaime Font, Park, Crystal, Miele, Lucio, Goldstein, Julia, Bonvini, Ezio, Porrás, Almudena, Laborda, Jorge
Published in The Journal of biological chemistry (21.11.1997)
Published in The Journal of biological chemistry (21.11.1997)
Get full text
Journal Article
Epidermal Growth Factor (EGF) Receptor Kinase-independent Signaling by EGF
Deb, Tushar B., Su, Leon, Wong, Lily, Bonvini, Ezio, Wells, Alan, David, Michael, Johnson, Gibbes R.
Published in The Journal of biological chemistry (04.05.2001)
Published in The Journal of biological chemistry (04.05.2001)
Get full text
Journal Article
Membrane Raft-Dependent Regulation of Phospholipase Cγ-1 Activation in T Lymphocytes
Verı́, Maria-Concetta, DeBell, Karen E., Seminario, Maria-Cristina, DiBaldassarre, Angela, Reischl, Ilona, Rawat, Rashmi, Graham, Laurie, Noviello, Cristiana, Rellahan, Barbara L., Miscia, Sebastiano, Wange, Ronald L., Bonvini, Ezio
Published in Molecular and Cellular Biology (01.10.2001)
Published in Molecular and Cellular Biology (01.10.2001)
Get full text
Journal Article