1,5-Benzodiazepines, a Novel Class of Hepatitis C Virus Polymerase Nonnucleoside Inhibitors
NYANGUILE, Origene, PAUWELS, Frederik, DEHERTOGH, Pascale, CUMMINGS, Maxwell D, BONFANTI, Jean-Francois, SIMMEN, Kenneth A, RABOISSON, Pierre, VAN DEN BROECK, Walter, BOUTTON, Carlo W, QUIRYNEN, Ludo, IVENS, Tania, VAN DER HELM, Liesbet, VANDERCRUYSSEN, Geneviève, MOSTMANS, Wendy, DELOUVROY, Frédéric
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Published in Antimicrobial Agents and Chemotherapy (01.12.2008)
Get full text
Journal Article
A pan-serotype dengue virus inhibitor targeting the NS3-NS4B interaction
Kaptein, Suzanne J F, Goethals, Olivia, Kiemel, Dominik, Marchand, Arnaud, Kesteleyn, Bart, Bonfanti, Jean-François, Bardiot, Dorothée, Stoops, Bart, Jonckers, Tim H M, Dallmeier, Kai, Geluykens, Peggy, Thys, Kim, Crabbe, Marjolein, Chatel-Chaix, Laurent, Münster, Max, Querat, Gilles, Touret, Franck, de Lamballerie, Xavier, Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Van Loock, Marnix, Neyts, Johan
Published in Nature (London) (21.10.2021)
Published in Nature (London) (21.10.2021)
Get full text
Journal Article
A novel pyrimidine forming cyclization
Leenders, Ruben, van de Sande, Marc, Bonfanti, Jean-François
Published in Tetrahedron letters (02.01.2020)
Published in Tetrahedron letters (02.01.2020)
Get full text
Journal Article
Discovery of JNJ-1802, a First-in-Class Pan-Serotype Dengue Virus NS4B Inhibitor
Kesteleyn, Bart, Bonfanti, Jean-François, Bardiot, Dorothée, De Boeck, Benoît, Goethals, Olivia, Kaptein, Suzanne J. F., Stoops, Bart, Coesemans, Erwin, Fortin, Jérôme, Muller, Philippe, Doublet, Frédéric, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Loock, Marnix Van, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H. M.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
Get full text
Journal Article
Discovery of Acyl-Indole Derivatives as Pan-Serotype Dengue Virus NS4B Inhibitors
Kesteleyn, Bart, Bardiot, Dorothée, Bonfanti, Jean-François, De Boeck, Benoît, Goethals, Olivia, Kaptein, Suzanne J. F., Stoops, Bart, Coesemans, Erwin, Fortin, Jérôme, Muller, Philippe, Doublet, Frédéric, Carlens, Gunter, Koukni, Mohamed, Smets, Wim, Raboisson, Pierre, Chaltin, Patrick, Simmen, Kenny, Van Loock, Marnix, Neyts, Johan, Marchand, Arnaud, Jonckers, Tim H. M.
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
Get full text
Journal Article
Palladium Catalyzed One-Pot Sequential Suzuki Cross-Coupling–Direct C–H Functionalization of Imidazo[1,2‑a]pyrazines
Gembus, Vincent, Bonfanti, Jean-François, Querolle, Olivier, Jubault, Philippe, Levacher, Vincent, Hoarau, Christophe
Published in Organic letters (07.12.2012)
Published in Organic letters (07.12.2012)
Get full text
Journal Article
Practical Synthesis of Ethyl 3‑Fluoro-1-pyrrole-2-carboxylate: A Key Fragment of a Potent Drug Candidate against Hepatitis B Virus
René, Adeline, Quilan, Maxime, Deng, Yicheng, Cheng, Yang, Teleha, Christopher A, Raboisson, Pierre, Bonfanti, Jean-François, Fortin, Jérôme, Charette, André. B, Pannecoucke, Xavier, Poisson, Thomas, Jubault, Philippe
Published in Organic process research & development (15.05.2020)
Published in Organic process research & development (15.05.2020)
Get full text
Journal Article
Pan-serotype dengue virus inhibitor JNJ-A07 targets NS4A-2K-NS4B interaction with NS2B/NS3 and blocks replication organelle formation
Kiemel, Dominik, Kroell, Ann-Sophie Helene, Denolly, Solène, Haselmann, Uta, Bonfanti, Jean-François, Andres, Jose Ignacio, Ghosh, Brahma, Geluykens, Peggy, Kaptein, Suzanne J F, Wilken, Lucas, Scaturro, Pietro, Neyts, Johan, Van Loock, Marnix, Goethals, Olivia, Bartenschlager, Ralf
Published in Nature communications (19.07.2024)
Published in Nature communications (19.07.2024)
Get full text
Journal Article
Toward the Synthesis of Fluorinated Analogues of HCV NS3/4A Serine Protease Inhibitors Using Methyl α‑Amino-β-fluoro-β-vinylcyclopropanecarboxylate as Key Intermediate
Milanole, Gaëlle, Andriessen, Floris, Lemonnier, Gérald, Sebban, Muriel, Coadou, Gaël, Couve-Bonnaire, Samuel, Bonfanti, Jean-François, Jubault, Philippe, Pannecoucke, Xavier
Published in Organic letters (19.06.2015)
Published in Organic letters (19.06.2015)
Get full text
Journal Article
Antiviral Activity of TMC353121, a Respiratory Syncytial Virus (RSV) Fusion Inhibitor, in a Non-Human Primate Model
Ispas, Gabriela, Koul, Anil, Verbeeck, Johan, Sheehan, Jennifer, Sanders-Beer, Brigitte, Roymans, Dirk, Andries, Koen, Rouan, Marie-Claude, De Jonghe, Sandra, Bonfanti, Jean-François, Vanstockem, Marc, Simmen, Kenneth, Verloes, Rene
Published in PloS one (26.05.2015)
Published in PloS one (26.05.2015)
Get full text
Journal Article
Synthesis of Fluorinated Cyclopropyl Amino Acid Analogues: Toward the Synthesis of Original Fluorinated Peptidomimetics
Milanole, Gaëlle, Couve-Bonnaire, Samuel, Bonfanti, Jean-François, Jubault, Philippe, Pannecoucke, Xavier
Published in Journal of organic chemistry (18.01.2013)
Published in Journal of organic chemistry (18.01.2013)
Get full text
Journal Article
From Oxetane to Thietane: Extending the Antiviral Spectrum of 2′-Spirocyclic Uridines by Substituting Oxygen with Sulfur
Grosse, Sandrine, Tahri, Abdellah, Raboisson, Pierre, Houpis, Yannis, Stoops, Bart, Jacoby, Edgar, Neefs, Jean-Marc, Van Loock, Marnix, Goethals, Olivia, Geluykens, Peggy, Bonfanti, Jean-François, Jonckers, Tim H. M.
Published in ACS medicinal chemistry letters (08.12.2022)
Published in ACS medicinal chemistry letters (08.12.2022)
Get full text
Journal Article
Binding of a potent small-molecule inhibitor of six-helix bundle formation requires interactions with both heptad-repeats of the RSV fusion protein
Roymans, Dirk, De Bondt, Hendrik L, Arnoult, Eric, Geluykens, Peggy, Gevers, Tom, Van Ginderen, Marcia, Verheyen, Nick, Kim, Hidong, Willebrords, Rudy, Bonfanti, Jean-François, Bruinzeel, Wouter, Cummings, Maxwell D, van Vlijmen, Herman, Andries, Koen
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (05.01.2010)
Get full text
Journal Article
Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate. 2. Discovery of a Morpholinopropylaminobenzimidazole Derivative (TMC353121)
Bonfanti, Jean-François, Meyer, Christophe, Doublet, Frédéric, Fortin, Jérôme, Muller, Philippe, Queguiner, Laurence, Gevers, Tom, Janssens, Peggy, Szel, Heidi, Willebrords, Rudy, Timmerman, Philip, Wuyts, Koen, van Remoortere, Pieter, Janssens, Frans, Wigerinck, Piet, Andries, Koen
Published in Journal of medicinal chemistry (28.02.2008)
Published in Journal of medicinal chemistry (28.02.2008)
Get full text
Journal Article
1,5-Benzodiazepine inhibitors of HCV NS5B polymerase
McGowan, David, Nyanguile, Origène, Cummings, Maxwell D., Vendeville, Sandrine, Vandyck, Koen, Van den Broeck, Walter, Boutton, Carlo W., De Bondt, Hendrik, Quirynen, Ludo, Amssoms, Katie, Bonfanti, Jean-François, Last, Stefaan, Rombauts, Klara, Tahri, Abdellah, Hu, Lili, Delouvroy, Frédéric, Vermeiren, Katrien, Vandercruyssen, Geneviève, Van der Helm, Liesbet, Cleiren, Erna, Mostmans, Wendy, Lory, Pedro, Pille, Geert, Van Emelen, Kristof, Fanning, Gregory, Pauwels, Frederik, Lin, Tse-I, Simmen, Kenneth, Raboisson, Pierre
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Published in Bioorganic & medicinal chemistry letters (01.05.2009)
Get full text
Journal Article
Selection of a Respiratory Syncytial Virus Fusion Inhibitor Clinical Candidate, Part 1: Improving the Pharmacokinetic Profile Using the Structure−Property Relationship
Bonfanti, Jean-François, Doublet, Frédéric, Fortin, Jérôme, Lacrampe, Jean, Guillemont, Jérôme, Muller, Philippe, Queguiner, Laurence, Arnoult, Eric, Gevers, Tom, Janssens, Peggy, Szel, Heidi, Willebrords, Rudy, Timmerman, Philip, Wuyts, Koen, Janssens, Frans, Sommen, Cois, Wigerinck, Piet, Andries, Koen
Published in Journal of medicinal chemistry (20.09.2007)
Published in Journal of medicinal chemistry (20.09.2007)
Get full text
Journal Article
뎅기열 질환의 치료 및 예방
VAN LOOCK MARNIX, NEYTS JOHAN, BONFANTI JEAN FRANCOIS, KAPTEIN SUZANNE, KESTELEYN BART RUDOLF ROMANIE, GOETHALS OLIVIA GABRIELLA M, JONCKERS TIM HUGO MARIA, STOOPS BART HENRI THERESIA
Year of Publication 19.07.2022
Get full text
Year of Publication 19.07.2022
Patent
Blocking NS3-NS4B interaction inhibits dengue virus in non-human primates
Goethals, Olivia, Kaptein, Suzanne J F, Kesteleyn, Bart, Bonfanti, Jean-François, Van Wesenbeeck, Liesbeth, Bardiot, Dorothée, Verschoor, Ernst J, Verstrepen, Babs E, Fagrouch, Zahra, Putnak, J Robert, Kiemel, Dominik, Ackaert, Oliver, Straetemans, Roel, Lachau-Durand, Sophie, Geluykens, Peggy, Crabbe, Marjolein, Thys, Kim, Stoops, Bart, Lenz, Oliver, Tambuyzer, Lotke, De Meyer, Sandra, Dallmeier, Kai, McCracken, Michael K, Gromowski, Gregory D, Rutvisuttinunt, Wiriya, Jarman, Richard G, Karasavvas, Nicos, Touret, Franck, Querat, Gilles, de Lamballerie, Xavier, Chatel-Chaix, Laurent, Milligan, Gregg N, Beasley, David W C, Bourne, Nigel, Barrett, Alan D T, Marchand, Arnaud, Jonckers, Tim H M, Raboisson, Pierre, Simmen, Kenny, Chaltin, Patrick, Bartenschlager, Ralf, Bogers, Willy M, Neyts, Johan, Van Loock, Marnix
Published in Nature (London) (23.03.2023)
Published in Nature (London) (23.03.2023)
Get full text
Journal Article
스피로티에탄 뉴클레오시드
BONFANTI JEAN FRANCOIS, RABOISSON PIERRE JEAN MARIE BERNARD, JONCKERS TIM HUGO MARIA, TAHRI ABDELLAH
Year of Publication 28.04.2020
Get full text
Year of Publication 28.04.2020
Patent
매크로사이클릭 플루 엔도뉴클레아제 억제제
HENDRICKS ROBERT THAN, BONFANTI JEAN FRANCOIS, RABOISSON PIERRE JEAN MARIE BERNARD, MERCEY GUILLAUME JEAN MAURICE, FORTIN JEROME MICHEL CLAUDE, STOYCHEVA ANTITSA DIMITROVA
Year of Publication 21.06.2021
Get full text
Year of Publication 21.06.2021
Patent