Screening for modulators of neural network activity in 3D human iPSC-derived cortical spheroids
Woodruff, Grace, Phillips, Naomi, Carromeu, Cassiano, Guicherit, Oivin, White, Alistair, Johnson, McCay, Zanella, Fabian, Anson, Blake, Lovenberg, Timothy, Bonaventure, Pascal, Harrington, Anthony W
Published in PloS one (22.10.2020)
Published in PloS one (22.10.2020)
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Translational evaluation of novel selective orexin-1 receptor antagonist JNJ-61393215 in an experimental model for panic in rodents and humans
Salvadore, Giacomo, Bonaventure, Pascal, Shekhar, Anantha, Johnson, Philip L., Lord, Brian, Shireman, Brock T., Lebold, Terry P., Nepomuceno, Diane, Dugovic, Christine, Brooks, Sander, Zuiker, Rob, Bleys, Cathy, Tatikola, Kanaka, Remmerie, Bart, Jacobs, Gabriel E., Schruers, Koen, Moyer, John, Nash, Abigail, Van Nueten, Luc G. M., Drevets, Wayne C.
Published in Translational psychiatry (07.09.2020)
Published in Translational psychiatry (07.09.2020)
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The Zinc Transporter SLC39A7 (ZIP7) Is Essential for Regulation of Cytosolic Zinc Levels
Woodruff, Grace, Bouwkamp, Christian G, de Vrij, Femke M, Lovenberg, Timothy, Bonaventure, Pascal, Kushner, Steven A, Harrington, Anthony W
Published in Molecular pharmacology (01.09.2018)
Published in Molecular pharmacology (01.09.2018)
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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects
Bonaventure, Pascal, Yun, Sujin, Johnson, Philip L, Shekhar, Anantha, Fitz, Stephanie D, Shireman, Brock T, Lebold, Terry P, Nepomuceno, Diane, Lord, Brian, Wennerholm, Michelle, Shelton, Jonathan, Carruthers, Nicholas, Lovenberg, Timothy, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2015)
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Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432
Lord, Brian, Aluisio, Leah, Shoblock, James R, Neff, Robert A, Varlinskaya, Elena I, Ceusters, Marc, Lovenberg, Timothy W, Carruthers, Nicholas, Bonaventure, Pascal, Letavic, Michael A, Deak, Terrence, Drinkenburg, Wilhelmus, Bhattacharya, Anindya
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2014)
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Journal Article
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia
Bonaventure, Pascal, Shelton, Jonathan, Yun, Sujin, Nepomuceno, Diane, Sutton, Steven, Aluisio, Leah, Fraser, Ian, Lord, Brian, Shoblock, James, Welty, Natalie, Chaplan, Sandra R, Aguilar, Zuleima, Halter, Robin, Ndifor, Anthony, Koudriakova, Tatiana, Rizzolio, Michele, Letavic, Michael, Carruthers, Nicholas I, Lovenberg, Timothy, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2015)
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Selective blockade of the orexin-2 receptor attenuates ethanol self-administration, place preference, and reinstatement
Shoblock, James R., Welty, Natalie, Aluisio, Leah, Fraser, Ian, Motley, S. Timothy, Morton, Kirsten, Palmer, James, Bonaventure, Pascal, Carruthers, Nicholas I., Lovenberg, Timothy W., Boggs, Jamin, Galici, Ruggero
Published in Psychopharmacologia (01.05.2011)
Published in Psychopharmacologia (01.05.2011)
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Blockade of Orexin-1 Receptors Attenuates Orexin-2 Receptor Antagonism-Induced Sleep Promotion in the Rat
Dugovic, Christine, Shelton, Jonathan E, Aluisio, Leah E, Fraser, Ian C, Jiang, Xiaohui, Sutton, Steven W, Bonaventure, Pascal, Yun, Sujin, Li, Xiaorong, Lord, Brian, Dvorak, Curt A, Carruthers, Nicholas I, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2009)
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Journal Article
GPR139 and Dopamine D2 Receptor Co-express in the Same Cells of the Brain and May Functionally Interact
Wang, Lien, Lee, Grace, Kuei, Chester, Yao, Xiang, Harrington, Anthony, Bonaventure, Pascal, Lovenberg, Timothy W, Liu, Changlu
Published in Frontiers in neuroscience (26.03.2019)
Published in Frontiers in neuroscience (26.03.2019)
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Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain
Smith, Craig M., Shen, Pei-Juan, Banerjee, Avantika, Bonaventure, Pascal, Ma, Sherie, Bathgate, Ross A.D., Sutton, Steven W., Gundlach, Andrew L.
Published in Journal of comparative neurology (1911) (01.10.2010)
Published in Journal of comparative neurology (1911) (01.10.2010)
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Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor
Wyatt, Ryan M, Fraser, Ian, Welty, Natalie, Lord, Brian, Wennerholm, Michelle, Sutton, Steven, Ameriks, Michael K, Dugovic, Christine, Yun, Sujin, White, Allison, Nguyen, Leslie, Koudriakova, Tatiana, Tian, Gaochao, Suarez, Javier, Szewczuk, Lawrence, Bonnette, William, Ahn, Kay, Ghosh, Brahma, Flores, Christopher M, Connolly, Peter J, Zhu, Bin, Macielag, Mark J, Brandt, Michael R, Chevalier, Kristen, Zhang, Sui-Po, Lovenberg, Timothy, Bonaventure, Pascal
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2020)
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Journal Article
Orexin Depolarizes Central Amygdala Neurons via Orexin Receptor 1, Phospholipase C and Sodium-Calcium Exchanger and Modulates Conditioned Fear
Dustrude, Erik T, Caliman, Izabela F, Bernabe, Cristian S, Fitz, Stephanie D, Grafe, Laura A, Bhatnagar, Seema, Bonaventure, Pascal, Johnson, Philip L, Molosh, Andrei I, Shekhar, Anantha
Published in Frontiers in neuroscience (18.12.2018)
Published in Frontiers in neuroscience (18.12.2018)
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Journal Article
Selective Blockade of 5-Hydroxytryptamine (5-HT)7 Receptors Enhances 5-HT Transmission, Antidepressant-Like Behavior, and Rapid Eye Movement Sleep Suppression Induced by Citalopram in Rodents
Bonaventure, Pascal, Kelly, Lisa, Aluisio, Leah, Shelton, Jonathan, Lord, Brian, Galici, Ruggero, Miller, Kirsten, Atack, John, Lovenberg, Timothy W, Dugovic, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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Journal Article
Translational evaluation of JNJ-18038683, a 5-hydroxytryptamine type 7 receptor antagonist, on rapid eye movement sleep and in major depressive disorder
Bonaventure, Pascal, Dugovic, Christine, Kramer, Michelle, De Boer, Peter, Singh, Jaskaran, Wilson, Sue, Bertelsen, Kirk, Di, Jianing, Shelton, Jonathan, Aluisio, Leah, Dvorak, Lisa, Fraser, Ian, Lord, Brian, Nepomuceno, Diane, Ahnaou, Abdellah, Drinkenburg, Wilhelmus, Chai, Wenying, Dvorak, Curt, Sands, Steve, Carruthers, Nicholas, Lovenberg, Timothy W
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2012)
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Journal Article
Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation
Bonaventure, Pascal, Dugovic, Christine, Shireman, Brock, Preville, Cathy, Yun, Sujin, Lord, Brian, Nepomuceno, Diane, Wennerholm, Michelle, Lovenberg, Timothy, Carruthers, Nicolas, Fitz, Stephanie D, Shekhar, Anantha, Johnson, Philip L
Published in Frontiers in pharmacology (09.06.2017)
Published in Frontiers in pharmacology (09.06.2017)
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Journal Article
F13. Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Properties of the Selective Orexin-1 Receptor Antagonist JNJ-61393215: Results From the First-In-Human and Multiple Ascending Dose Studies
Salvadore, Giacomo, Brooks, Sander, Cathy, Bleys, Moyer, John, Shireman, Brock, Bonaventure, Pascal, Remmerie, Bart, Tatikola, Kanaka, Jacobs, Gabriel, van Nueten, Luc, Drevets, Wayne
Published in Biological psychiatry (1969) (01.05.2019)
Published in Biological psychiatry (1969) (01.05.2019)
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In vivo Characterization of a Selective, Orally Available, and Brain Penetrant Small Molecule GPR139 Agonist
Shoblock, James R, Welty, Natalie, Fraser, Ian, Wyatt, Ryan, Lord, Brian, Lovenberg, Timothy, Liu, Changlu, Bonaventure, Pascal
Published in Frontiers in pharmacology (21.03.2019)
Published in Frontiers in pharmacology (21.03.2019)
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Journal Article
Zolpidem reduces hippocampal neuronal activity in freely behaving mice: a large scale calcium imaging study with miniaturized fluorescence microscope
Berdyyeva, Tamara, Otte, Stephani, Aluisio, Leah, Ziv, Yaniv, Burns, Laurie D, Dugovic, Christine, Yun, Sujin, Ghosh, Kunal K, Schnitzer, Mark J, Lovenberg, Timothy, Bonaventure, Pascal
Published in PloS one (05.11.2014)
Published in PloS one (05.11.2014)
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Genomic and functional conservation of sedative-hypnotic targets in the zebrafish
Renier, Corinne, Faraco, Juliette H, Bourgin, Patrice, Motley, Timothy, Bonaventure, Pascal, Rosa, Frédéric, Mignot, Emmanuel
Published in Pharmacogenetics and genomics (01.04.2007)
Published in Pharmacogenetics and genomics (01.04.2007)
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