Characterization of tritiated JNJ-GluN2B-5 (3-3H 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo3,2-bpyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors
Schoellerman, Jeffrey, Lord, Brian, Bhattacharya, Anindya, Stenne, Brice, Wall, Jessica L, Rech, Jason, Letavic, Michael, Bonaventure, Pascal, Balana, Bartosz
Published in Journal of neurochemistry (01.09.2024)
Published in Journal of neurochemistry (01.09.2024)
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Characterization of tritiated JNJ‐GluN2B‐5 (3‐ 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolopyridin‐1‐yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors
Schoellerman, Jeffrey, Lord, Brian, Bhattacharya, Anindya, Brice Stenne, Wall, Jessica L, Rech, Jason, Letavic, Michael, Bonaventure, Pascal, Balana, Bartosz
Published in Journal of neurochemistry (01.09.2024)
Published in Journal of neurochemistry (01.09.2024)
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Prischich, Davia, Sortino, Rosalba, Gomila-Juaneda, Alexandre, Matera, Carlo, Guardiola, Salvador, Nepomuceno, Diane, Varese, Monica, Bonaventure, Pascal, de Lecea, Luis, Giralt, Ernest, Gorostiza, Pau
Published in Cellular and molecular life sciences : CMLS (01.12.2024)
Published in Cellular and molecular life sciences : CMLS (01.12.2024)
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Characterization of tritiated JNJ‐GluN2B‐5 (3‐[3H] 1‐(azetidin‐1‐yl)‐2‐(6‐(4‐fluoro‐3‐methyl‐phenyl)pyrrolo[3,2‐b]pyridin‐1‐yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors
Schoellerman, Jeffrey, Lord, Brian, Bhattacharya, Anindya, Stenne, Brice, Wall, Jessica L., Rech, Jason, Letavic, Michael, Bonaventure, Pascal, Balana, Bartosz
Published in Journal of neurochemistry (01.09.2024)
Published in Journal of neurochemistry (01.09.2024)
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Characterization of Selective M 5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum
Zell, Vivien, Teuns, Greetje, Needham, Alexandra Stormy, Mukherjee, Sruti, Roscoe, Nathaniel, Le, Michelle, Fourgeaud, Lawrence, Woodruff, Grace, Bhattacharya, Anindya, Marella, Mathieu, Bonaventure, Pascal, Drevets, Wayne C., Balana, Bartosz
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
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Pharmacological characterization of a novel centrally permeable P2X7 receptor antagonist: JNJ‐47965567
Bhattacharya, Anindya, Wang, Qi, Ao, Hong, Shoblock, James R, Lord, Brian, Aluisio, Leah, Fraser, Ian, Nepomuceno, Diane, Neff, Robert A, Welty, Natalie, Lovenberg, Timothy W, Bonaventure, Pascal, Wickenden, Alan D, Letavic, Michael A
Published in British journal of pharmacology (01.10.2013)
Published in British journal of pharmacology (01.10.2013)
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Journal Article
Characterization of Selective M5 Acetylcholine Muscarinic Receptor Modulators on Dopamine Signaling in the Striatum
Zell, Vivien, Teuns, Greetje, Needham, Alexandra Stormy, Mukherjee, Sruti, Roscoe, Nathaniel, Le, Michelle, Fourgeaud, Lawrence, Woodruff, Grace, Bhattacharya, Anindya, Marella, Mathieu, Bonaventure, Pascal, Drevets, Wayne C, Balana, Bartosz
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2023)
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Journal Article
Identification and characterization of select oxysterols as ligands for GPR17
Harrington, Anthony W., Liu, Changlu, Phillips, Naomi, Nepomuceno, Diane, Kuei, Chester, Chang, Joseph, Chen, Weixuan, Sutton, Steven W., O'Malley, Daniel, Pham, Ly, Yao, Xiang, Sun, Siquan, Bonaventure, Pascal
Published in British journal of pharmacology (01.02.2023)
Published in British journal of pharmacology (01.02.2023)
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Journal Article
Selective orexin receptor antagonists
Lebold, Terry P., Bonaventure, Pascal, Shireman, Brock T.
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
Published in Bioorganic & medicinal chemistry letters (01.09.2013)
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Putative role of GPR139 on sleep modulation using pharmacological and genetic rodent models
Wang, Lien, Dugovic, Christine, Yun, Sujin, White, Allison, Lord, Brian, Dvorak, Curt, Liu, Changlu, Lovenberg, Timothy, Bonaventure, Pascal
Published in European journal of pharmacology (05.09.2020)
Published in European journal of pharmacology (05.09.2020)
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Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyra- zolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate
Dvorak, Curt A., Rudolph, Dale A., Nepomuceno, Diane, Dvorak, Lisa, Lord, Brian, Fraser, Ian, Bonaventure, Pascal, Lovenberg, Timothy, Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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Emerging role of GPR139 on sleep modulation and stress response in rodent models
Dugovic, Christine, Yun, Sujin, Wang, Lien, Liu, Changlu, Dvorak, Curt, Lovenberg, Timothy, Bonaventure, Pascal
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
Published in Proceedings for Annual Meeting of The Japanese Pharmacological Society (2018)
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Journal Article
F10. Cue-Induced Conditioned Fear Learning Requires Orexin Receptor 1 Signaling in the Central Amygdala
Dustrude, Erik, Caliman, Izabela, Bernabe, Cristian, Fitz, Stephanie, Grafe, Laura, Bhatnagar, Seema, Bonaventure, Pascal, Johnson, Philip, Molosh, Andrei, Shekhar, Anantha
Published in Biological psychiatry (1969) (15.05.2019)
Published in Biological psychiatry (1969) (15.05.2019)
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73. Using Opto-Chemogenetics to Assess the Role of Orexin/Glutamate Hypothalamic System in Panic/Phobia and to Identify Panic/Phobia Off/On Inputs
Johnson, Philip, Bernabe, Cristian, Caliman, Izabela, Fitz, Stephanie, Abreu, Aline, Molosh, Andrei, Bhatnagar, Seema, Bonaventure, Pascal, Shekhar, Anantha
Published in Biological psychiatry (1969) (15.05.2019)
Published in Biological psychiatry (1969) (15.05.2019)
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Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus
Lord, Brian, Wintmolders, Cindy, Langlois, Xavier, Nguyen, Leslie, Lovenberg, Tim, Bonaventure, Pascal
Published in European journal of pharmacology (05.09.2013)
Published in European journal of pharmacology (05.09.2013)
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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate
Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya
Published in Journal of medicinal chemistry (08.06.2017)
Published in Journal of medicinal chemistry (08.06.2017)
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OREXIN 1 AND 2 RECEPTOR INVOLVEMENT IN CO2-INDUCED PANIC-ASSOCIATED BEHAVIOR AND AUTONOMIC RESPONSES
Johnson, Philip L., Federici, Lauren M., Fitz, Stephanie D., Renger, John J., Shireman, Brock, Winrow, Christopher J., Bonaventure, Pascal, Shekhar, Anantha
Published in Depression and anxiety (01.09.2015)
Published in Depression and anxiety (01.09.2015)
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161. A Pilot Screen for Neurite Growth-Promoting Compounds: A Comparison between Human iPS and Primary Rodent Neurons
Harrington, Anthony, Phillips, Naomi, Woodruff, Grace, Purcell, Sean, Bonaventure, Pascal, Lovenberg, Timothy
Published in Biological psychiatry (1969) (15.05.2017)
Published in Biological psychiatry (1969) (15.05.2017)
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Journal Article
Discovery and SAR studies of 2-alkyl-3-phenyl-2,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepines as 5-HT7/2 inhibitors leading to the identification of a clinical candidate
Dvorak, Curt A., Rudolph, Dale A., Nepomuceno, Diane, Dvorak, Lisa, Lord, Brian, Fraser, Ian, Bonaventure, Pascal, Lovenberg, Timothy, Carruthers, Nicholas I.
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
Published in Bioorganic & medicinal chemistry letters (01.01.2021)
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