Tyrosine kinase inhibitors: From rational design to clinical trials
Traxler, Peter, Bold, Guido, Buchdunger, Elisabeth, Caravatti, Giorgio, Furet, Pascal, Manley, Paul, O'Reilly, Terence, Wood, Jeanette, Zimmermann, Juerg
Published in Medicinal research reviews (01.11.2001)
Published in Medicinal research reviews (01.11.2001)
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Journal Article
Conference Proceeding
Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis
Manley, Paul William, Bold, Guido, Brüggen, Josef, Fendrich, Gabrielle, Furet, Pascal, Mestan, Jürgen, Schnell, Christian, Stolz, Barbara, Meyer, Thomas, Meyhack, Bernd, Stark, Wilhelm, Strauss, Andre, Wood, Jeanette
Published in BBA - Proteins and Proteomics (11.03.2004)
Published in BBA - Proteins and Proteomics (11.03.2004)
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Book Review
Journal Article
New Anilinophthalazines as Potent and Orally Well Absorbed Inhibitors of the VEGF Receptor Tyrosine Kinases Useful as Antagonists of Tumor-Driven Angiogenesis
Bold, Guido, Altmann, Karl-Heinz, Frei, Jörg, Lang, Marc, Manley, Paul W, Traxler, Peter, Wietfeld, Bernhard, Brüggen, Josef, Buchdunger, Elisabeth, Cozens, Robert, Ferrari, Stefano, Furet, Pascal, Hofmann, Francesco, Martiny-Baron, Georg, Mestan, Jürgen, Rösel, Johannes, Sills, Matthew, Stover, David, Acemoglu, Figan, Boss, Eugen, Emmenegger, René, Lässer, Laurent, Masso, Elvira, Roth, Rosemarie, Schlachter, Christian, Vetterli, Werner, Wyss, Dominique, Wood, Jeanette M
Published in Journal of medicinal chemistry (15.06.2000)
Published in Journal of medicinal chemistry (15.06.2000)
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Journal Article
Anthranilic Acid Amides: A Novel Class of Antiangiogenic VEGF Receptor Kinase Inhibitors
Manley, Paul W, Furet, Pascal, Bold, Guido, Brüggen, Josef, Mestan, Jürgen, Meyer, Thomas, Schnell, Christian R, Wood, Jeanette, Haberey, Martin, Huth, Andreas, Krüger, Martin, Menrad, Andreas, Ottow, Eckhard, Seidelmann, Dieter, Siemeister, Gerhard, Thierauch, Karl-Heinz
Published in Journal of medicinal chemistry (19.12.2002)
Published in Journal of medicinal chemistry (19.12.2002)
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Journal Article
Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines
Traxler, Peter, Bold, Guido, Frei, Joerg, Lang, Marc, Lydon, Nicholas, Mett, Helmut, Buchdunger, Elisabeth, Meyer, Thomas, Mueller, Marcel, Furet, Pascal
Published in Journal of medicinal chemistry (24.10.1997)
Published in Journal of medicinal chemistry (24.10.1997)
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Journal Article
Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching
Furet, Pascal, Bold, Guido, Hofmann, Francesco, Manley, Paul, Meyer, Thomas, Altmann, Karl-Heinz
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
The Total Synthesis and Biological Assessment of trans-Epothilone A
Altmann, Karl-Heinz, Bold, Guido, Caravatti, Giorgio, Denni, Donatienne, Flörsheimer, Andreas, Schmidt, Alfred, Rihs, Grety, Wartmann, Markus
Published in Helvetica chimica acta (01.11.2002)
Published in Helvetica chimica acta (01.11.2002)
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Journal Article
Epothilones and Their Analogs – Potential New Weapons in the Fight Against Cancer
Karl-Heinz Altmann, Guido Bold, Giorgio Caravatti, Nicole End, Andreas Flörsheimer, Vito Guagnano, Terence O'Reilly, Markus Wartmann
Published in Chimia (01.01.2000)
Published in Chimia (01.01.2000)
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Journal Article
Discovery of Potent, Highly Selective, and In Vivo Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing
Pissot Soldermann, Carole, Simic, Oliver, Renatus, Martin, Erbel, Paulus, Melkko, Samu, Wartmann, Markus, Bigaud, Marc, Weiss, Andreas, McSheehy, Paul, Endres, Ralf, Santos, Paulo, Blank, Jutta, Schuffenhauer, Ansgar, Bold, Guido, Buschmann, Nicole, Zoller, Thomas, Altmann, Eva, Manley, Paul W, Dix, Ina, Buchdunger, Elisabeth, Scesa, Julien, Quancard, Jean, Schlapbach, Achim, Bornancin, Frédéric, Radimerski, Thomas, Régnier, Catherine H
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Journal Article
The T‐cell fingerprint of MALT1 paracaspase revealed by selective inhibition
Bardet, Maureen, Unterreiner, Adeline, Malinverni, Claire, Lafossas, Frédérique, Vedrine, Corinne, Boesch, Danielle, Kolb, Yeter, Kaiser, Daniel, Glück, Anton, Schneider, Martin A, Katopodis, Andreas, Renatus, Martin, Simic, Oliver, Schlapbach, Achim, Quancard, Jean, Régnier, Catherine H, Bold, Guido, Pissot‐Soldermann, Carole, Carballido, José M, Kovarik, Jiri, Calzascia, Thomas, Bornancin, Frédéric
Published in Immunology and cell biology (01.01.2018)
Published in Immunology and cell biology (01.01.2018)
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Journal Article
A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis
Bold, Guido, Schnell, Christian, Furet, Pascal, McSheehy, Paul, Brüggen, Josef, Mestan, Jürgen, Manley, Paul W, Drückes, Peter, Burglin, Marion, Dürler, Ursula, Loretan, Jacqueline, Reuter, Robert, Wartmann, Markus, Theuer, Andreas, Bauer-Probst, Beatrice, Martiny-Baron, Georg, Allegrini, Peter, Goepfert, Arnaud, Wood, Jeanette, Littlewood-Evans, Amanda
Published in Journal of medicinal chemistry (14.01.2016)
Published in Journal of medicinal chemistry (14.01.2016)
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Journal Article
Inhibition of Chronic and Acute Skin Inflammation by Treatment with a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor
Halin, Cornelia, Fahrngruber, Hermann, Meingassner, Josef G, Bold, Guido, Littlewood-Evans, Amanda, Stuetz, Anton, Detmar, Michael
Published in The American journal of pathology (01.07.2008)
Published in The American journal of pathology (01.07.2008)
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Journal Article
Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction
Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
Published in Bioorganic & medicinal chemistry letters (01.05.2014)
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Journal Article
Purification and characterization of dihydrodipicolinate synthase from pea
Dereppe, C. (Ciba-Geigy Ltd., Basel, Switzerland), Bold, G, Ghisalba, O, Ebert, E, Schar, H.P
Published in Plant physiology (Bethesda) (01.03.1992)
Published in Plant physiology (Bethesda) (01.03.1992)
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Journal Article
A General Strategy for Targeting Drugs to Bone
Jahnke, Wolfgang, Bold, Guido, Marzinzik, Andreas L., Ofner, Silvio, Pellé, Xavier, Cotesta, Simona, Bourgier, Emmanuelle, Lehmann, Sylvie, Henry, Chrystelle, Hemmig, René, Stauffer, Frédéric, Hartwieg, J. Constanze D., Green, Jonathan R., Rondeau, Jean-Michel
Published in Angewandte Chemie International Edition (23.11.2015)
Published in Angewandte Chemie International Edition (23.11.2015)
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Journal Article
Corrigendum to “Tetra-substituted imidazoles as a new class of inhibitors of the p53–MDM2 interaction” [Bioorg. Med. Chem. Lett. 24 (9) (2014) 2110–2114]
Vaupel, Andrea, Bold, Guido, De Pover, Alain, Stachyra-Valat, Thérèse, Hergovich Lisztwan, Joanna, Kallen, Joerg, Masuya, Keiichi, Furet, Pascal
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Journal Article
Aromatic Interactions with Phenylalanine 691 and Cysteine 828: A Concept for FMS-like Tyrosine Kinase-3 Inhibition. Application to the Discovery of a New Class of Potential Antileukemia Agents
Furet, Pascal, Bold, Guido, Meyer, Thomas, Roesel, Johannes, Guagnano, Vito
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
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Journal Article
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
WOOD, J. M, BOLD, G, PERSOHN, E, RÖSEL, J, SCHNELL, C, STOVER, D, THEUER, A, TOWBIN, H, WENGER, F, WOODS-COOK, K, MENRAD, A, SIEMEISTER, G, BUCHDUNGER, E, SCHIRNER, M, THIERAUCH, K.-H, SCHNEIDER, M. R, DREVS, J, MARTINY-BARON, G, TOTZKE, F, MARME, D, COZENS, R, FERRARI, S, FREI, J, HOFMANN, F, MESTAN, J, METT, H, O'REILLY, T
Published in Cancer research (Chicago, Ill.) (15.04.2000)
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Published in Cancer research (Chicago, Ill.) (15.04.2000)
Journal Article