The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection
Hewawasam, Piyasena, Fan, Wenhong, Knipe, Jay, Moon, Sandra L, Boissard, Christopher G, Gribkoff, Valentin K, Starrett, John E
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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Journal Article
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels
HEWAWASAM, Piyasena, GRIBKOFF, Valentin K, PAJOR, Lorraine M, KNIPE, Jay, QI GAO, PERRONE, Robert, STARRETT, John E, PENDRI, Yadagiri, DWORETZKY, Steven I, MEANWELL, Nicholas A, MARTINEZ, Eduardo, BOISSARD, Christopher G, POST-MUNSON, Debra J, TROJNACKI, Joanne T, YELESWARAM, Krishnaswamy
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Kaczmarek, Leonard K, Joiner, William J, Tang, Michael D, Wang, Lu-Yang, Dworetzky, Steven I, Boissard, Christopher G, Gan, Li, Gribkoff, Valentin K
Published in Nature neuroscience (01.10.1998)
Published in Nature neuroscience (01.10.1998)
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Journal Article
Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective Properties
Hewawasam, Piyasena, Erway, Matthew, Moon, Sandra L, Knipe, Jay, Weiner, Harvey, Boissard, Christopher G, Post-Munson, Debra J, Gao, Qi, Huang, Stella, Gribkoff, Valentin K, Meanwell, Nicholas A
Published in Journal of medicinal chemistry (28.03.2002)
Published in Journal of medicinal chemistry (28.03.2002)
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Journal Article
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain
Wu, Yong-Jin, Conway, Charles M., Sun, Li-Qiang, Machet, Frederic, Chen, Jie, Chen, Ping, He, Huan, Bourin, Clotilde, Calandra, Vincenzo, Polino, Joseph L., Davis, Carl D., Heman, Karen, Gribkoff, Valentin K., Boissard, Christopher G., Knox, Ronald J., Thompson, Mark W., Fitzpatrick, William, Weaver, David, Harden, David G., Natale, Joanne, Dworetzky, Steven I., Starrett, John E.
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
Published in Bioorganic & medicinal chemistry letters (15.11.2013)
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Journal Article
Pharmacological activation and inhibition of Slack ( Slo2.2) channels
Yang, Bo, Gribkoff, Valentin K., Pan, Jennifer, Damagnez, Veronique, Dworetzky, Steven I., Boissard, Christopher G., Bhattacharjee, Arin, Yan, Yangyang, Sigworth, Fred J., Kaczmarek, Leonard K.
Published in Neuropharmacology (01.09.2006)
Published in Neuropharmacology (01.09.2006)
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3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR
Romine, Jeffrey L, Martin, Scott W, Meanwell, Nicholas A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Moon, Sandra, Ortiz, Astrid, Yeleswaram, Swamy, Pajor, Lorraine, Gao, Qi, Starrett, Jr, John E
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Journal Article
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction
Hewawasam, Piyasena, Fan, Wenhong, Ding, Min, Flint, Kim, Cook, Deborah, Goggins, Gregory D, Myers, Robert A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Starrett, John E, Lodge, Nicholas J
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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Journal Article
Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K Potassium Channel Openers
Vrudhula, Vivekananda M, Dasgupta, Bireshwar, Qian-Cutrone, Jingfang, Kozlowski, Edward S, Boissard, Christopher G, Dworetzky, Steven I, Wu, Dedong, Gao, Qi, Kimura, Roy, Gribkoff, Valentin K, Starrett, John E
Published in Journal of medicinal chemistry (08.03.2007)
Published in Journal of medicinal chemistry (08.03.2007)
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Journal Article
(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: An Orally Bioavailable KCNQ2 Opener with Significant Activity in a Cortical Spreading Depression Model of Migraine
Wu, Yong-Jin, Boissard, Christopher G, Greco, Corinne, Gribkoff, Valentin K, Harden, David G, He, Huan, L'Heureux, Alexandre, Kang, Shing Hong, Kinney, Gene G, Knox, Ronald J, Natale, Joanne, Newton, Amy E, Lehtinen-Oboma, Sanna, Sinz, Michael W, Sivarao, Digavalli V, Starrett, John E, Sun, Li-Qiang, Tertyshnikova, Svetlana, Thompson, Mark W, Weaver, David, Wong, Henry S, Zhang, Lei, Dworetzky, Steven I
Published in Journal of medicinal chemistry (17.07.2003)
Published in Journal of medicinal chemistry (17.07.2003)
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Journal Article
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction
BOY, Kenneth M, GUERNON, Jason M, STARRETT, John E, SIT, Sing-Yuen, XIE, Kai, HEWAWASAM, Piyasena, BOISSARD, Christopher G, DWORETZKY, Steven I, NATALE, Joanne, GRIBKOFF, Valentin K, LODGE, Nicholas
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Journal Article
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: Opener of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels, Identification, Solubility, and SAR
Romine, Jeffrey L, Martin, Scott W, Meanwell, Nicholas A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Moon, Sandra, Ortiz, Astrid, Yeleswaram, Swamy, Pajor, Lorraine, Gao, Qi, Starrett, John E
Published in Journal of medicinal chemistry (08.02.2007)
Published in Journal of medicinal chemistry (08.02.2007)
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Journal Article
4-Aryl-3-(mercapto)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle
Hewawasam, Piyasena, Fan, Wenhong, Cook, Deborah A., Newberry, Kimberly S., Boissard, Christopher G., Gribkoff, Valentin K., Starrett, John, Lodge, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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Journal Article
Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers
Wu, Yong-Jin, He, Huan, Sun, Li-Qiang, L'Heureux, Alexandre, Chen, Jie, Dextraze, Pierre, Starrett, John E, Boissard, Christopher G, Gribkoff, Valentin K, Natale, Joanne, Dworetzky, Steven I
Published in Journal of medicinal chemistry (20.05.2004)
Published in Journal of medicinal chemistry (20.05.2004)
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Journal Article
4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels
Romine, Jeffrey L, Martin, Scott W, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Li, Yi, Gao, Qi, Meanwell, Nicholas A, Starrett, Jr, John E
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Journal Article
The synthesis and structure–activity relationships of 3-amino-4-benzylquinolin-2-ones: discovery of novel KCNQ2 channel openers
Hewawasam, Piyasena, Chen, Nathan, Ding, Min, Natale, Joanne T., Boissard, Christopher G., Yeola, Sarita, Gribkoff, Valentin K., Starrett, John, Dworetzky, Steven I.
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
Published in Bioorganic & medicinal chemistry letters (05.04.2004)
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Journal Article
( S)- N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2 H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons
Wu, Yong-Jin, Boissard, Christopher G, Chen, Jie, Fitzpatrick, William, Gao, Qi, Gribkoff, Valentin K, Harden, David G, He, Huan, Knox, Ronald J, Natale, Joanne, Pieschl, Rick L, Starrett, John E, Sun, Li-Qiang, Thompson, Mark, Weaver, David, Wu, Dedong, Dworetzky, Steven I
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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Journal Article
4,5-Diphenyltriazol-3-ones: Openers of Large-Conductance Ca2+-Activated Potassium (Maxi-K) Channels
Romine, Jeffrey L, Martin, Scott W, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Natale, Joanne, Li, Yi, Gao, Qi, Meanwell, Nicholas A, Starrett, John E
Published in Journal of medicinal chemistry (04.07.2002)
Published in Journal of medicinal chemistry (04.07.2002)
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Journal Article
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1 H-indol-5-yl)-ethyl acrylamides
Wu, Yong-Jin, Sun, Li-Qiang, He, Huan, Chen, Jie, Starrett, John E, Dextraze, Pierre, Daris, Jean-Paul, Boissard, Christopher G, Pieschl, Rick L, Gribkoff, Valentin K, Natale, Joanne, Knox, Ronald J, Harden, David G, Thompson, Mark W, Fitzpatrick, William, Weaver, David, Wu, Dedong, Gao, Qi, Dworetzky, Steven I
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
Published in Bioorganic & medicinal chemistry letters (06.09.2004)
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Journal Article
Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes
Vrudhula, Vivekananda M., Dasgupta, Bireshwar, Boissard, Christopher G., Gribkoff, Valentin K., Santone, Kenneth S., Dalterio, Richard A., Lodge, Nicholas J., Starrett, John E.
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
Published in Bioorganic & medicinal chemistry letters (01.10.2005)
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