Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle
Niewoehner, Jens, Bohrmann, Bernd, Collin, Ludovic, Urich, Eduard, Sade, Hadassah, Maier, Peter, Rueger, Petra, Stracke, Jan Olaf, Lau, Wilma, Tissot, Alain C, Loetscher, Hansruedi, Ghosh, Anirvan, Freskgård, Per-Ola
Published in Neuron (Cambridge, Mass.) (08.01.2014)
Published in Neuron (Cambridge, Mass.) (08.01.2014)
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Journal Article
TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
Xiang, Xianyuan, Werner, Georg, Bohrmann, Bernd, Liesz, Arthur, Mazaheri, Fargol, Capell, Anja, Feederle, Regina, Knuesel, Irene, Kleinberger, Gernot, Haass, Christian
Published in EMBO molecular medicine (01.09.2016)
Published in EMBO molecular medicine (01.09.2016)
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Journal Article
3D Structure of Alzheimer's Amyloid-β(1-42) Fibrils
Lührs, Thorsten, Christiane Ritter, Adrian, Marc, Dominique Riek-Loher, Bohrmann, Bernd, Döbeli, Heinz, Schubert, David, Riek, Roland, Gage, Fred H.
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (29.11.2005)
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Journal Article
Human stem cell–derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2
Claes, Christel, Van Den Daele, Johanna, Boon, Ruben, Schouteden, Sarah, Colombo, Alessio, Monasor, Laura Sebastian, Fiers, Mark, Ordovás, Laura, Nami, FatemehArefeh, Bohrmann, Bernd, Tahirovic, Sabina, De Strooper, Bart, Verfaillie, Catherine M.
Published in Alzheimer's & dementia (01.03.2019)
Published in Alzheimer's & dementia (01.03.2019)
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Journal Article
Brain Shuttle Antibody for Alzheimer’s Disease with Attenuated Peripheral Effector Function due to an Inverted Binding Mode
Weber, Felix, Bohrmann, Bernd, Niewoehner, Jens, Fischer, Jens A.A., Rueger, Petra, Tiefenthaler, Georg, Moelleken, Joerg, Bujotzek, Alexander, Brady, Kevin, Singer, Thomas, Ebeling, Martin, Iglesias, Antonio, Freskgård, Per-Ola
Published in Cell reports (Cambridge) (02.01.2018)
Published in Cell reports (Cambridge) (02.01.2018)
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Journal Article
Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice
Grueninger, Fiona, Bohrmann, Bernd, Czech, Christian, Ballard, Theresa Maria, Frey, Johann R, Weidensteiner, Claudia, von Kienlin, Markus, Ozmen, Laurence
Published in Neurobiology of disease (01.02.2010)
Published in Neurobiology of disease (01.02.2010)
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Journal Article
Sembragiline: A Novel, Selective Monoamine Oxidase Type B Inhibitor for the Treatment of Alzheimer’s Disease
Borroni, Edilio, Bohrmann, Bernd, Grueninger, Fiona, Prinssen, Eric, Nave, Stephane, Loetscher, Hansruedi, Chinta, Shankar J, Rajagopalan, Subramanian, Rane, Anand, Siddiqui, Almas, Ellenbroek, Bart, Messer, Juerg, Pähler, Axel, Andersen, Julie K, Wyler, Rene, Cesura, Andrea M
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2017)
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Journal Article
Transfer of tissue factor from leukocytes to platelets is mediated by CD15 and tissue factor
Rauch, Ursula, Bonderman, Diana, Bohrmann, Bernd, Badimon, Juan J., Himber, Jacques, Riederer, Markus A., Nemerson, Yale
Published in Blood (01.07.2000)
Published in Blood (01.07.2000)
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Journal Article
Blood-Borne Tissue Factor: Another View of Thrombosis
Peter L. A. Giesen, Rauch, Ursula, Bohrmann, Bernd, Kling, Dorothee, Roque, Merce, Fallon, John T., Badimon, Juan J., Himber, Jacques, Riederer, Markus A., Nemerson, Yale
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (02.03.1999)
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Journal Article
HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model
Melo, Esther, Oertle, Philipp, Trepp, Carolyn, Meistermann, Hélène, Burgoyne, Thomas, Sborgi, Lorenzo, Cabrera, Alvaro Cortes, Chen, Chia-yi, Hoflack, Jean-Christophe, Kam-Thong, Tony, Schmucki, Roland, Badi, Laura, Flint, Nicholas, Ghiani, Zeynep Eren, Delobel, Fréderic, Stucki, Corinne, Gromo, Giulia, Einhaus, Alfred, Hornsperger, Benoit, Golling, Sabrina, Siebourg-Polster, Juliane, Gerber, Francoise, Bohrmann, Bernd, Futter, Clare, Dunkley, Tom, Hiller, Sebastian, Schilling, Oliver, Enzmann, Volker, Fauser, Sascha, Plodinec, Marija, Iacone, Roberto
Published in EBioMedicine (01.01.2018)
Published in EBioMedicine (01.01.2018)
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Journal Article
Acute Renal Effects of Intravenous Bisphosphonates in the Rat
Pfister, Thomas, Atzpodien, Elke, Bohrmann, Bernd, Bauss, Frieder
Published in Basic & clinical pharmacology & toxicology (01.12.2005)
Published in Basic & clinical pharmacology & toxicology (01.12.2005)
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Journal Article
Coexpression of endothelin-converting enzyme-1 and endothelin-1 in different stages of human atherosclerosis
IHLING, Christian, SZOMBATHY, Thomas, BOHRMANN, Bernd, BROCKHAUS, Manfred, SCHAEFER, Hans E, LOEFFLER, Bernd M
Published in Circulation (New York, N.Y.) (21.08.2001)
Published in Circulation (New York, N.Y.) (21.08.2001)
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Journal Article
Cortical hypoperfusion in the B6.PS2APP mouse model for Alzheimer's disease: Comprehensive phenotyping of vascular and tissular parameters by MRI
Weidensteiner, Claudia, Metzger, Friedrich, Bohrmann, Andreas Bruns Bernd, Kuennecke, Basil, von Kienlin, Markus
Published in Magnetic resonance in medicine (01.07.2009)
Published in Magnetic resonance in medicine (01.07.2009)
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Journal Article
Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease
COLLIN, Ludovic, BOHRMANN, Bernd, GÖPFERT, Ulrich, OROSZLAN-SZOVIK, Krisztina, OZMEN, Laurence, GRÜNINGER, Fiona
Published in Brain (London, England : 1878) (01.10.2014)
Published in Brain (London, England : 1878) (01.10.2014)
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Journal Article
Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes
Shahmoradian, Sarah H, Lewis, Amanda J, Genoud, Christel, Hench, Jürgen, Moors, Tim E, Navarro, Paula P, Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N, Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J M, Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F, Quadri, Marialuisa, Van IJcken, Wilfred F J, Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D J, Lauer, Matthias E
Published in Nature neuroscience (01.07.2019)
Published in Nature neuroscience (01.07.2019)
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Journal Article
Combined treatment with a BACE inhibitor and anti-Aβ antibody gantenerumab enhances amyloid reduction in APPLondon mice
Jacobsen, Helmut, Ozmen, Laurence, Caruso, Antonello, Narquizian, Robert, Hilpert, Hans, Jacobsen, Bjoern, Terwel, Dick, Tanghe, An, Bohrmann, Bernd
Published in The Journal of neuroscience (27.08.2014)
Published in The Journal of neuroscience (27.08.2014)
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Journal Article
Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β
Bohrmann, Bernd, Baumann, Karlheinz, Benz, Jörg, Gerber, Francoise, Huber, Walter, Knoflach, Frédéric, Messer, Jürg, Oroszlan, Krisztina, Rauchenberger, Robert, Richter, Wolfgang F., Rothe, Christine, Urban, Margit, Bardroff, Michael, Winter, Michael, Nordstedt, Christer, Loetscher, Hansruedi
Published in Journal of Alzheimer's disease (01.01.2012)
Published in Journal of Alzheimer's disease (01.01.2012)
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Journal Article
A subcutaneous cellular implant for passive immunization against amyloid-β reduces brain amyloid and tau pathologies
Lathuilière, Aurélien, Laversenne, Vanessa, Astolfo, Alberto, Kopetzki, Erhard, Jacobsen, Helmut, Stampanoni, Marco, Bohrmann, Bernd, Schneider, Bernard L, Aebischer, Patrick
Published in Brain (London, England : 1878) (01.05.2016)
Published in Brain (London, England : 1878) (01.05.2016)
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Journal Article
Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation
Brendel, Matthias, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Probst, Federico, Gildehaus, Franz-Josef, Bartenstein, Peter, Haass, Christian, Bohrmann, Bernd, Herms, Jochen, Willem, Michael, Rominger, Axel
Published in Theranostics (01.01.2018)
Published in Theranostics (01.01.2018)
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Journal Article