5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis
Jin, Sha, Cojocari, Dan, Purkal, Julie J, Popovic, Relja, Talaty, Nari N, Xiao, Yu, Solomon, Larry R, Boghaert, Erwin R, Leverson, Joel D, Phillips, Darren C
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Published in Clinical cancer research (01.07.2020)
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Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
Punnoose, Elizabeth A, Leverson, Joel D, Peale, Franklin, Boghaert, Erwin R, Belmont, Lisa D, Tan, Nguyen, Young, Amy, Mitten, Michael, Ingalla, Ellen, Darbonne, Walter C, Oleksijew, Anatol, Tapang, Paul, Yue, Peng, Oeh, Jason, Lee, Leslie, Maiga, Sophie, Fairbrother, Wayne J, Amiot, Martine, Souers, Andrew J, Sampath, Deepak
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope
Phillips, Andrew C, Boghaert, Erwin R, Vaidya, Kedar S, Mitten, Michael J, Norvell, Suzanne, Falls, Hugh D, DeVries, Peter J, Cheng, Dong, Meulbroek, Jonathan A, Buchanan, Fritz G, McKay, Laura M, Goodwin, Neal C, Reilly, Edward B
Published in Molecular cancer therapeutics (01.04.2016)
Published in Molecular cancer therapeutics (01.04.2016)
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Application of LDH assay for therapeutic efficacy evaluation of ex vivo tumor models
Cox, Megan C., Mendes, Rita, Silva, Fernanda, Mendes, Teresa F., Zelaya-Lazo, Adelyn, Halwachs, Kathleen, Purkal, Julie J., Isidro, Inês A., Félix, Ana, Boghaert, Erwin R., Brito, Catarina
Published in Scientific reports (17.09.2021)
Published in Scientific reports (17.09.2021)
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Pevonedistat and azacitidine upregulate NOXA (PMAIP1) to increase sensitivity to venetoclax in preclinical models of acute myeloid leukemia
Cojocari, Dan, Smith, Brianna N, Purkal, Julie J, Arrate, Maria P, Huska, Jason D, Xiao, Yu, Gorska, Agnieszka, Hogdal, Leah J, Ramsey, Haley E, Boghaert, Erwin R, Phillips, Darren C, Savona, Michael R
Published in Haematologica (Roma) (01.04.2022)
Published in Haematologica (Roma) (01.04.2022)
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Tackling the tumor microenvironment - how can complex tumor models in vitro aid oncology drug development?
Cox, Megan C, Mendes, Rita, Halwachs, Kathleen N, Domenici, Giacomo, Brito, Catarina, Boghaert, Erwin R
Published in Expert opinion on drug discovery (03.07.2023)
Published in Expert opinion on drug discovery (03.07.2023)
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The Volume of Three-Dimensional Cultures of Cancer Cells In Vitro Influences Transcriptional Profile Differences and Similarities with Monolayer Cultures and Xenografted Tumors
Boghaert, Erwin R., Lu, Xin, Hessler, Paul E., McGonigal, Thomas P., Oleksijew, Anatol, Mitten, Michael J., Foster-Duke, Kelly, Hickson, Jonathan A., Santo, Vitor E., Brito, Catarina, Uziel, Tamar, Vaidya, Kedar S.
Published in Neoplasia (New York, N.Y.) (01.09.2017)
Published in Neoplasia (New York, N.Y.) (01.09.2017)
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Antitumor Efficacy of a Combination of CMC-544 (Inotuzumab Ozogamicin), a CD22-Targeted Cytotoxic Immunoconjugate of Calicheamicin, and Rituximab against Non-Hodgkin's B-Cell Lymphoma
DIJOSEPH, John F, DOUGHER, Maureen M, KALYANDRUG, Lyka B, ARMELLINO, Douglas C, BOGHAERT, Erwin R, HAMANN, Philip R, MORAN, Justin K, DAMLE, Nitin K
Published in Clinical cancer research (01.01.2006)
Published in Clinical cancer research (01.01.2006)
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Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma
DIJOSEPH, John F, GOAD, Mary E, DOUGHER, Maureen M, BOGHAERT, Erwin R, KUNZ, Arthur, HAMANN, Philip R, DAMLE, Nitin K
Published in Clinical cancer research (15.12.2004)
Published in Clinical cancer research (15.12.2004)
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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W
Published in Nature medicine (01.02.2013)
Published in Nature medicine (01.02.2013)
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CD20-specific antibody-targeted chemotherapy of non-Hodgkin's B-cell lymphoma using calicheamicin-conjugated rituximab
Dijoseph, John F, Dougher, Maureen M, Armellino, Douglas C, Kalyandrug, Lyka, Kunz, Arthur, Boghaert, Erwin R, Hamann, Philip R, Damle, Nitin K
Published in Cancer Immunology, Immunotherapy (01.07.2007)
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ABBV-399, a c-Met Antibody-Drug Conjugate that Targets Both MET -Amplified and c-Met-Overexpressing Tumors, Irrespective of MET Pathway Dependence
Wang, Jieyi, Anderson, Mark G, Oleksijew, Anatol, Vaidya, Kedar S, Boghaert, Erwin R, Tucker, Lora, Zhang, Qian, Han, Edward K, Palma, Joann P, Naumovski, Louie, Reilly, Edward B
Published in Clinical cancer research (15.02.2017)
Published in Clinical cancer research (15.02.2017)
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Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
Leverson, Joel D, Phillips, Darren C, Mitten, Michael J, Boghaert, Erwin R, Diaz, Dolores, Tahir, Stephen K, Belmont, Lisa D, Nimmer, Paul, Xiao, Yu, Ma, Xiaoju Max, Lowes, Kym N, Kovar, Peter, Chen, Jun, Jin, Sha, Smith, Morey, Xue, John, Zhang, Haichao, Oleksijew, Anatol, Magoc, Terrance J, Vaidya, Kedar S, Albert, Daniel H, Tarrant, Jacqueline M, La, Nghi, Wang, Le, Tao, Zhi-Fu, Wendt, Michael D, Sampath, Deepak, Rosenberg, Saul H, Tse, Chris, Huang, David C S, Fairbrother, Wayne J, Elmore, Steven W, Souers, Andrew J
Published in Science translational medicine (18.03.2015)
Published in Science translational medicine (18.03.2015)
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Targeting Multiple EGFR-expressing Tumors with a Highly Potent Tumor-selective Antibody–Drug Conjugate
Anderson, Mark G., Falls, Hugh D., Mitten, Michael J., Oleksijew, Anatol, Vaidya, Kedar S., Boghaert, Erwin R., Gao, Wenqing, Palma, Joann P., Cao, Diana, Chia, Puey-Ling, John, Thomas, Gan, Hui K., Scott, Andrew M., Reilly, Edward B.
Published in Molecular cancer therapeutics (01.10.2020)
Published in Molecular cancer therapeutics (01.10.2020)
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Antibody-targeted chemotherapy of B-cell lymphoma using calicheamicin conjugated to murine or humanized antibody against CD22
DIJOSEPH, John F, POPPLEWELL, Andrew, ZINKEWICH-PEOTTI, Karen, STEPHENS, Sue, WEIR, Neil, DAMLE, Nitin K, TICKLE, Simon, LADYMAN, Heather, LAWSON, Alastair, KUNZ, Arthur, KHANDKE, Kiran, ARMELLINO, Douglas C, BOGHAERT, Erwin R, HAMANN, Philip R
Published in Cancer Immunology, Immunotherapy (01.01.2005)
Published in Cancer Immunology, Immunotherapy (01.01.2005)
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Patient-derived ovarian cancer explants: preserved viability and histopathological features in long-term agitation-based cultures
Abreu, Sofia, Silva, Fernanda, Mendes, Rita, Mendes, Teresa F., Teixeira, Marta, Santo, Vítor E., Boghaert, Erwin R., Félix, Ana, Brito, Catarina
Published in Scientific reports (10.11.2020)
Published in Scientific reports (10.11.2020)
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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity
Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J
Published in ACS medicinal chemistry letters (09.10.2014)
Published in ACS medicinal chemistry letters (09.10.2014)
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Synergistic therapeutic benefit by combining the antibody drug conjugate, depatux-m with temozolomide in pre-clinical models of glioblastoma with overexpression of EGFR
Vaidya, Kedar S., Mitten, Michael J., Zelaya-Lazo, Adelyn L., Oleksijew, Anatol, Alvey, Cory, Falls, Hugh D., Mishra, Sasmita, Palma, Joann, Ansell, Peter, Phillips, Andrew C., Reilly, Edward B., Anderson, Mark, Boghaert, Erwin R.
Published in Journal of neuro-oncology (01.04.2021)
Published in Journal of neuro-oncology (01.04.2021)
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Patient-derived explants of colorectal cancer: histopathological and molecular analysis of long-term cultures
da Mata, Sara, Franchi-Mendes, Teresa, Abreu, Sofia, Filipe, Bruno, Morgado, Sónia, Mesquita, Marta, Albuquerque, Cristina, Fonseca, Ricardo, Santo, Vítor E., Boghaert, Erwin R., Rosa, Isadora, Brito, Catarina
Published in Cancers (19.09.2021)
Published in Cancers (19.09.2021)
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