Abstract 1342: Development and preclinical evaluation of unique first-in-class small molecule inhibitors of the anti-apoptotic protein FLIP
Higgins, Catherine A., Fox, Jennifer, Roberts, Jamie, Doherty, Declan, Perrior, Trevor, Boffey, Ray, Harrison, Tim, Longley, Daniel B.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Abstract 5220: Development of first-in-class small molecule inhibitors of FLIP which activate caspase-8, the nodal regulator of apoptosis, necroptosis and pyroptosis
Longley, Daniel B., Higgins, Catherine, Fox, Jennifer, Roberts, Jamie Z., Boffey, Ray, Williams, Sophie, Perrior, Trevor, Page, Martin J., Harrison, Tim
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Abstract 382: Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP
Higgins, Catherine A., Fox, Jennifer, Majkut, Joanna, Fiedler, Greti E., Roberts, Jamie, Humphreys, Luke, Boffey, Ray J., Perrior, Trevor R., Harrison, Timothy, Longley, Daniel B.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract B129: Development and preclinical assessment of a first-in-class small-molecule inhibitor of FLIP
Higgins, Catherine A., Majkut, Joanna, Fox, Jennifer, Humphreys, Luke, Fiedler, Greti Espona, Boffey, Ray J., Perrior, Trevor R., Haigh, David, Harrison, Timothy, Longley, Daniel B.
Published in Molecular cancer therapeutics (01.01.2018)
Published in Molecular cancer therapeutics (01.01.2018)
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Abstract LB-037: Development and preclinical assessment of a first-in-class small molecule inhibitor of the major cell death regulator protein FLIP
Majkut, Joanna, Higgins, Catherine, Malik, Adnan, Nemeth, Zsusannah, Blurton, Peter, Boffey, Ray, Perrior, Trevor R., Johnston, Patrick G., Haigh, David, Harrison, Timothy, Longley, Daniel B.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Synthesis and SAR studies of analogues of 4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A2A receptor ligands with improved aqueous solubility
Mikkelsen, Gitte Kobberøe, Langgård, Morten, Schrøder, Tenna Juul, Kreilgaard, Mads, Jørgensen, Erling B., Brandt, Guillaume, Griffon, Yann, Boffey, Ray, Bang-Andersen, Benny
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Abstract C5: FLIP protein-protein interaction inhibitors enhance sensitivity of colorectal cancer cells to chemotherapy and TRAIL
Fox, Jennifer P., Majkut, Joanna, Higgins, Catherine, Nemeth, Zsuzsanna, Malik, Adnan, Scott, Christopher J., Blurton, Peter, Boffey, Ray J., Perrior, Trevor R., Harrison, Timothy, Longley, Daniel B.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Abstract C4: Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP for treatment of NSCLC
Majkut, Joanna, Higgins, Catherine, Malik, Adnan, Nemeth, Zsusannah, Blurton, Peter, Boffey, Ray J., Perrior, Trevor R., Haigh, David, Harrison, Timothy, Longley, Daniel B.
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Synthesis and SAR studies of analogues of 4-(3,3-dimethylbutyrylamino)-3,5-difluoro-N-thiazol-2-yl-benzamide (Lu AA41063) as adenosine A(2A) receptor ligands with improved aqueous solubility
Mikkelsen, Gitte Kobberoe, Langgard, Morten, Schroder, Tenna Juul, Kreilgaard, Mads, Jorgensen, Erling B., Brandt, Guillaume, Griffon, Yann, Boffey, Ray, Bang-Andersen, Benny
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
Published in Bioorganic & medicinal chemistry letters (15.03.2015)
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Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitors
Elliott, Richard J. R., Jarvis, Ashley, Rajasekaran, Mohan B., Menon, Malini, Bowers, Leandra, Boffey, Ray, Bayford, Melanie, Firth-Clark, Stuart, Key, Rebekah, Aqil, Rehan, Kirton, Stewart B., Niculescu-Duvaz, Dan, Fish, Laura, Lopes, Filipa, McLeary, Robert, Trindade, Ines, Vendrell, Elisenda, Munkonge, Felix, Porter, Rod, Perrior, Trevor, Springer, Caroline, Oliver, Antony W., Pearl, Laurence H., Ashworth, Alan, Lord, Christopher J.
Published in MedChemComm (01.01.2015)
Published in MedChemComm (01.01.2015)
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Design and discovery of 3-aryl-5-substituted-isoquinolin-1-ones as potent tankyrase inhibitorsElectronic supplementary information (ESI) available: For complete experimental details for the TNKS homology model generation and virtual screen, chemical synthesis, biological assays and X-ray crystallography see ESI. The PDB accession codes for the X-ray co-crystal structure of TNKS + 12, TNKS + 21 and TNKS + 23 are 4UW1, 4U6A and 4UUH, respectively. See DOI: 10.1039/c5md00210a
Elliott, Richard J. R, Jarvis, Ashley, Rajasekaran, Mohan B, Menon, Malini, Bowers, Leandra, Boffey, Ray, Bayford, Melanie, Firth-Clark, Stuart, Key, Rebekah, Aqil, Rehan, Kirton, Stewart B, Niculescu-Duvaz, Dan, Fish, Laura, Lopes, Filipa, McLeary, Robert, Trindade, Ines, Vendrell, Elisenda, Munkonge, Felix, Porter, Rod, Perrior, Trevor, Springer, Caroline, Oliver, Antony W, Pearl, Laurence H, Ashworth, Alan, Lord, Christopher J
Year of Publication 02.09.2015
Year of Publication 02.09.2015
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Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase
Jackson, Sharon A., Sahni, Sukhveen, Lee, Lan, Luo, Yongyi, Nieduzak, Thaddeus R., Liang, Guyan, Chiang, Yulin, Collar, Nicola, Fink, David, He, Wei, Laoui, Abdelazize, Merrill, Jean, Boffey, Ray, Crackett, Peter, Rees, Bryan, Wong, Melanie, Guilloteau, Jean-Pierre, Mathieu, Magali, Rebello, Sam S.
Published in Bioorganic & medicinal chemistry (15.04.2005)
Published in Bioorganic & medicinal chemistry (15.04.2005)
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2,6-substituert-4-monosubstituert aminopyrimidin som prostaglandin D2 reseptorantagonister og farmasøytiske sammensetninger inneholdene disse, samt anvendelse av disse for fremstilling av et medikament
Gillespy, Timothy Alan, Dechaux, Elsa, Lim, Sungtaek, Cao, Bin, Boffey, Ray, Harris, Keith John, Aguiar, Joacy C, Hunt, Hazel J, Stefany, David, Gardner, Charles J
Year of Publication 30.01.2017
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Year of Publication 30.01.2017
Patent
2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINE AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
HAZEL JOAN DYKE, RAY BOFFEY, TIMOTHY GILLESPY, JOACY AGUIAR, BIN CAO, KEITH JOHN HARRIS, ELSA AMANDINE DECHAUX, DAVID STEFANY, CHARLES J. GARDNER, SUNGTAEK LIM
Year of Publication 15.04.2016
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Year of Publication 15.04.2016
Patent
2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
GARDNER, CHARLES J, CAO, BIN, BOFFEY, RAY, AGUIAR, JOACY C, DECHAUX, ELSA A, GILLESPY, TIMOTHY A, HUNT, HAZEL J, HARRIS, KEITH JOHN, LIM, SUNGTAEK, STEFANY, DAVID
Year of Publication 31.12.2012
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Year of Publication 31.12.2012
Patent
2,6-substituerede, 4-monosubstituerede aminopyrimidiner som prostaglandin-D2-receptorantagonister
GARDNER, CHARLES J, CAO, BIN, BOFFEY, RAY, AGUIAR, JOACY, C, DECHAUX, ELSA A, GILLESPY, TIMOTHY A, HUNT, HAZEL J, HARRIS, KEITH JOHN, LIM, SUNGTAEK, STEFANY, DAVID
Year of Publication 05.11.2012
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Year of Publication 05.11.2012
Patent
2,6-SUBSTITUTED-4-MONOSUBSTITUTEDAMINO-PYRIMIDINES AS PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS
GARDNER, CHARLES J, CAO, BIN, BOFFEY, RAY, AGUIAR, JOACY, C, DECHAUX, ELSA A, GILLESPY, TIMOTHY A, HUNT, HAZEL J, HARRIS, KEITH JOHN, LIM, SUNGTAEK, STEFANY, DAVID
Year of Publication 25.07.2012
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Year of Publication 25.07.2012
Patent