Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds
Sakatis, Melanie Z, Reese, Melinda J, Harrell, Andrew W, Taylor, Maxine A, Baines, Ian A, Chen, Liangfu, Bloomer, Jackie C, Yang, Eric Y, Ellens, Harma M, Ambroso, Jeffrey L, Lovatt, Cerys A, Ayrton, Andrew D, Clarke, Stephen E
Published in Chemical research in toxicology (15.10.2012)
Published in Chemical research in toxicology (15.10.2012)
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The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756)--a selective CXCR2 antagonist --in healthy adult subjects
Miller, Bruce E, Mistry, Sunil, Smart, Kevin, Connolly, Paul, Carpenter, Donald C, Cooray, Hiran, Bloomer, Jackie C, Tal-Singer, Ruth, Lazaar, Aili L
Published in BMC pharmacology & toxicology (20.06.2015)
Published in BMC pharmacology & toxicology (20.06.2015)
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Assessment of potential drug interactions by characterization of human drug metabolism pathways using non‐invasive bile sampling
Bloomer, Jackie C., Nash, Mike, Webb, Alison, Miller, Bruce E., Lazaar, Aili L., Beaumont, Claire, Guiney, William J.
Published in British journal of clinical pharmacology (01.02.2013)
Published in British journal of clinical pharmacology (01.02.2013)
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Utilizing Drug-Drug Interaction Prediction Tools during Drug Development: Enhanced Decision Making Based on Clinical Risk
SHARDLOW, Carole E, GENERAUX, Grant T, MACLAUCHLIN, Christopher C, PONS, Nicoletta, SKORDOS, Konstantine W, BLOOMER, Jackie C
Published in Drug metabolism and disposition (01.11.2011)
Published in Drug metabolism and disposition (01.11.2011)
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Negative Food Effect of Danirixin: Use of PBPK Modelling to Explore the Effect of Formulation and Meal Type on Clinical PK
Lloyd, Richard S., Hingle, Martin I., Bloomer, Jackie C., Charles, Stephen J., Butler, James M., Paul, Alan, Zhu, Xiaofeng, Miller, Bruce, D’Amico, Donald, Donald, Alison, Tal-Singer, Ruth, Ambery, Claire
Published in Pharmaceutical research (01.12.2020)
Published in Pharmaceutical research (01.12.2020)
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A randomized study of the safety and pharmacokinetics of GSK3358699, a mononuclear myeloid‐targeted bromodomain and extra‐terminal domain inhibitor
Brown, Jack A., Bal, Joanne, Simeoni, Monica, Williams, Peter, Mander, Palwinder K., Soden, Peter E., Daga, Shruti, Fahy, William A., Wong, Gabriel K., Bloomer, Jackie C., Erwig, Lars, Cui, Yi, Fernando, Disala, Carnaghan, Helen, Banham‐Hall, Edward J., Hopkins, Sarah, Davis, Bill G., Oliveira, Joao J. D., Prinjha, Rabinder K.
Published in British journal of clinical pharmacology (01.05.2022)
Published in British journal of clinical pharmacology (01.05.2022)
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Identification and characterisation of a salt form of Danirixin with reduced pharmacokinetic variability in patient populations
Bloomer, Jackie C., Ambery, Claire, Miller, Bruce E., Connolly, Paul, Garden, Helen, Henley, Nick, Hodnett, Neil, Keel, Sarah, Kreindler, James L., Lloyd, Richard S., Matthews, Wayne, Yonchuk, John, Lazaar, Aili L.
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2017)
Published in European journal of pharmaceutics and biopharmaceutics (01.08.2017)
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The pharmacokinetics of conventional and bioenhanced tablet formulations of danirixin (GSK1325756) following oral administration in healthy, elderly, human volunteers
Miller, Bruce E., Smart, Kevin, Mistry, Sunil, Ambery, Claire L., Bloomer, Jackie C., Connolly, Paul, Sanderson, Dominic, Shreeves, Trevor, Smith, Rachel, Lazaar, Aili L.
Published in European journal of drug metabolism and pharmacokinetics (01.09.2014)
Published in European journal of drug metabolism and pharmacokinetics (01.09.2014)
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Journal Article
Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SULT1A1, demonstrates improved selectivity with 2-aminophenol
Riches, Zoe, Bloomer, Jackie C., Coughtrie, Michael W.H.
Published in Biochemical pharmacology (15.07.2007)
Published in Biochemical pharmacology (15.07.2007)
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Journal Article
The identification of clinical candidate SB-480848 : A potent inhibitor of lipoprotein-associated phospholipase A2
BLACKIE, Josie A, BLOOMER, Jackie C, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, BROWN, Murray J. B, CHENG, Hung-Yuan, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann, MACPHEE, Colin H
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
Published in Bioorganic & medicinal chemistry letters (24.03.2003)
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The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-associated phospholipase A2 for evaluation in man
BLACKIE, Josie A, BLOOMER, Jackie C, MACPHEE, Colin H, MILLINER, Kevin J, MOORES, Kitty E, PINTO, Ivan L, SMITH, Stephen A, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, BROWN, Murray J. B, CHENG, Hung-Yuan, ELLIOTT, Richard L, HAMMOND, Beverley, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, LEWIS, V. Ann
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Journal Article
1-(Arylpiperazinylamidoalkyl)-pyrimidones : Orally active inhibitors of lipoprotein-associated phospholipase A2
BLOOMER, Jackie C, BOYD, Helen F, STANSFIELD, Ian G, STANWAY, Steven J, TAYLOR, Maxine A, THEOBALD, Colin J, WHITTAKER, Caroline M, HICKEY, Deirdre M. B, IFE, Robert J, LEACH, Colin A, MACPHEE, Colin H, MILLINER, Kevin J, PINTO, Ivan L, RAWLINGS, D. Anthony, SMITH, Stephen A
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
Published in Bioorganic & medicinal chemistry letters (23.07.2001)
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Journal Article
Comparison of 2-aminophenol and 4-nitrophenol as in vitro probe substrates for the major human hepatic sulfotransferase, SILT1A1, demonstrates improved selectivity with 2-aminophenol
RICHES, Zoe, BLOOMER, Jackie C, COUGHTRIE, Michael W. H
Published in Biochemical pharmacology (2007)
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Published in Biochemical pharmacology (2007)
Journal Article
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A 2
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J.
Published in Bioorganic & medicinal chemistry letters (2003)
Published in Bioorganic & medicinal chemistry letters (2003)
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Journal Article
The discovery of SB-435495. A potent, orally active inhibitor of lipoprotein-associated phospholipase A(2) for evaluation in man
Blackie, Josie A, Bloomer, Jackie C, Brown, Murray J B, Cheng, Hung-Yuan, Elliott, Richard L, Hammond, Beverley, Hickey, Deirdre M B, Ife, Robert J, Leach, Colin A, Lewis, V Ann, Macphee, Colin H, Milliner, Kevin J, Moores, Kitty E, Pinto, Ivan L, Smith, Stephen A, Stansfield, Ian G, Stanway, Steven J, Taylor, Maxine A, Theobald, Colin J, Whittaker, Caroline M
Published in Bioorganic & medicinal chemistry letters (16.09.2002)
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Published in Bioorganic & medicinal chemistry letters (16.09.2002)
Journal Article
The discovery of SB-435495
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
Published in Bioorganic & medicinal chemistry letters (01.09.2002)
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Journal Article
The discovery of SB-435495: A potent, orally active inhibitor of lipoprotein-Associated phospholipase A 2 for evaluation in man
Blackie, Josie A., Bloomer, Jackie C., Brown, Murray J.B., Cheng, Hung-Yuan, Elliott, Richard L., Hammond, Beverley, Hickey, Deirdre M.B., Ife, Robert J., Leach, Colin A., Lewis, V.Ann, Macphee, Colin H., Milliner, Kevin J., Moores, Kitty E., Pinto, Ivan L., Smith, Stephen A., Stansfield, Ian G., Stanway, Steven J., Taylor, Maxine A., Theobald, Colin J., Whittaker, Caroline M.
Published in Bioorganic & medicinal chemistry letters (2002)
Published in Bioorganic & medicinal chemistry letters (2002)
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Journal Article