A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b
Zhou, Hua, Olsen, Henrik, So, Edward, Mérigeon, Emmanuel, Rybin, Denis, Owens, Jane, LaRosa, Gregory, Block, David S., Strome, Scott E., Zhang, Xiaoyu
Published in Blood advances (14.03.2017)
Published in Blood advances (14.03.2017)
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Complement component C1q is an immunological rheostat that regulates Fc:FcγR interactions
So, Edward C., Zhou, Hua, Greenwell, Ariana, Burch, Erin E., Ji, Yaping, Mérigeon, Emmanuel Y., Olsen, Henrik S., Bentzen, Søren M., Block, David S., Zhang, Xiaoyu, Strome, Scott E.
Published in Immunogenetics (New York) (01.08.2023)
Published in Immunogenetics (New York) (01.08.2023)
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Recombinant human IgG1 based Fc multimers, with limited FcR binding capacity, can effectively inhibit complement-mediated disease
Sun, Haoping, Olsen, Henrik S., Mérigeon, Emmanuel Y., So, Edward, Burch, Erin, Kinsey, Susan, Papadimitriou, John C., Drachenberg, Cinthia B., Bentzen, Søren M., Block, David S., Strome, Scott E., Zhang, Xiaoyu
Published in Journal of autoimmunity (01.11.2017)
Published in Journal of autoimmunity (01.11.2017)
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Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease
Zhang, Xiaoyu, Olsen, Henrik S, Chen, Shaodong, So, Edward, Zhou, Hua, Burch, Erin, Mérigeon, Emmanuel Y, Block, David S, Strome, Scott E
Published in The Journal of immunology (1950) (01.02.2016)
Published in The Journal of immunology (1950) (01.02.2016)
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Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice
Jain, Ajay, Olsen, Henrik S, Vyzasatya, Ravi, Burch, Erin, Sakoda, Yukimi, Mérigeon, Emmanuel Y, Cai, Ling, Lu, Changwan, Tan, Ming, Tamada, Koji, Schulze, Dan, Block, David S, Strome, Scott E
Published in Arthritis research & therapy (20.08.2012)
Published in Arthritis research & therapy (20.08.2012)
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Ecdysteroid concentrations through various life-stages of the meiobenthic harpacticoid copepod, Amphiascus tenuiremis and the benthic estuarine amphipod, Leptocheirus plumulosus
Block, David S, Bejarano, Adriana C, Thomas Chandler, G
Published in General and comparative endocrinology (01.06.2003)
Published in General and comparative endocrinology (01.06.2003)
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A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity
Zhang, Xiaoyu, Owens, Jane, Olsen, Henrik S, So, Edward, Burch, Erin, McCroskey, Mark C, Li, Xianfeng, Weber, Gregory L, Bennett, Donald, Rybin, Denis, Zhou, Hua, Hao, Haiping, Mérigeon, Emmanuel Y, Block, David S, LaRosa, Gregory, Strome, Scott E
Published in JCI insight (24.01.2019)
Published in JCI insight (24.01.2019)
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An ACE2-IgG4 Fc Fusion Protein Demonstrates Strong Binding to All Tested SARS-CoV-2 Variants and Reduced Lung Inflammation in Animal Models of SARS-CoV-2 and Influenza
Merigeon, Emmanuel Y, Yang, Dong, Ihms, Elizabeth A, Bassit, Leda C, Fitzpatrick, Elizabeth A, Jonsson, Colleen B, Schinazi, Raymond F, Block, David S, Olsen, Henrik S
Published in Pathogens & immunity (2022)
Published in Pathogens & immunity (2022)
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Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer
Jain, Ajay, Poonia, Bhawna, So, Edward C, Vyzasatya, Ravi, Burch, Erin E, Olsen, Henrik S, Mérigeon, Emmanuel Y, Block, David S, Zhang, Xiaoyu, Schulze, Dan H, Hanna, Nader N, Twadell, William S, Yfantis, Harris G, Chan, Siaw L, Cai, Ling, Strome, Scott E
Published in European journal of cancer (1990) (01.10.2013)
Published in European journal of cancer (1990) (01.10.2013)
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Endocrine-mediated effects of UV-A irradiation on grass shrimp ( Palaemonetes pugio) reproduction
Volz, David C, Wirth, Edward F, Fulton, Michael H, Scott, Geoffrey I, Block, David S, Chandler, G.Thomas
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01.11.2002)
Published in Comparative biochemistry and physiology. Toxicology & pharmacology (01.11.2002)
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