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A phase I clinical trial of 2-chlorodeoxyadenosine in pediatric patients with acute leukemia
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Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3
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Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate
Spencer, H T, Sorrentino, B P, Pui, C H, Chunduru, S K, Sleep, S E, Blakley, R L
Published in Leukemia (01.03.1996)
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Role of aspartate 27 in the binding of methotrexate to dihydrofolate reductase from Escherichia coli
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Published in The Journal of biological chemistry (05.07.1988)
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Complete hematologic remissions induced by 2-chlorodeoxyadenosine in children with newly diagnosed acute myeloid leukemia
SANTANA, V. M, HURWITZ, C. A, BLAKLEY, R. L, CROM, W. R, XIAOLONG LUO, ROBERTS, W. M, RIBEIRO, R, HAZEM MAHMOUD, KRANCE, R. A
Published in Blood (15.08.1994)
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Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants
Patel, M, Sleep, S E, Lewis, W S, Spencer, H T, Mareya, S M, Sorrentino, B P, Blakley, R L
Published in Human gene therapy (20.11.1997)
Published in Human gene therapy (20.11.1997)
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Unusual transient- and steady-state kinetic behavior is predicted by the kinetic scheme operational for recombinant human dihydrofolate reductase
APPLEMAN, J. R, BEARD, W. A, DELCAMP, T. J, PRENDERGAST, N. J, FREISHEIM, J. H, BLAKLEY, R. L
Published in The Journal of biological chemistry (15.02.1990)
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Pharmacokinetics of cladribine (2-chlorodeoxyadenosine) in children with acute leukemia
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Published in Cancer research (Chicago, Ill.) (01.03.1994)
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Published in Cancer research (Chicago, Ill.) (01.03.1994)
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Hydride transfer by dihydrofolate reductase. Causes and consequences of the wide range of rates exhibited by bacterial and vertebrate enzymes
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Published in The Journal of biological chemistry (05.06.1989)
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Published in The Journal of biological chemistry (05.06.1989)
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In vivo selection of retrovirally transduced hematopoietic stem cells
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Published in Nature medicine (01.10.1998)
Published in Nature medicine (01.10.1998)
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