Scaffold Diversity of Exemplified Medicinal Chemistry Space
Langdon, Sarah R, Brown, Nathan, Blagg, Julian
Published in Journal of chemical information and modeling (26.09.2011)
Published in Journal of chemical information and modeling (26.09.2011)
Get full text
Journal Article
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening
Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I, Clarke, Paul A, Musil, Djordje, Schwarz, Daniel, Dale, Trevor, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
Get full text
Journal Article
Catalytic inhibition of KDM1A in Ewing sarcoma is insufficient as a therapeutic strategy
Romo‐Morales, Antonio, Aladowicz, Ewa, Blagg, Julian, Gatz, Susanne A., Shipley, Janet M.
Published in Pediatric blood & cancer (01.09.2019)
Published in Pediatric blood & cancer (01.09.2019)
Get full text
Journal Article
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
Get full text
Journal Article
High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers
Anderhub, Simon J, Mak, Grace Wing-Yan, Gurden, Mark D, Faisal, Amir, Drosopoulos, Konstantinos, Walsh, Katie, Woodward, Hannah L, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Theofani, Efthymia, Filosto, Simone, Saville, Harry, Burke, Rosemary, van Montfort, Rob L M, Raynaud, Florence I, Blagg, Julian, Hoelder, Swen, Eccles, Suzanne A, Linardopoulos, Spiros
Published in Molecular cancer therapeutics (01.10.2019)
Published in Molecular cancer therapeutics (01.10.2019)
Get full text
Journal Article
Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells
Rodgers, Ursula R, Lanyon-Hogg, Thomas, Masumoto, Naoko, Ritzefeld, Markus, Burke, Rosemary, Blagg, Julian, Magee, Anthony I, Tate, Edward W
Published in ACS chemical biology (16.12.2016)
Published in ACS chemical biology (16.12.2016)
Get full text
Journal Article
Diverse functionalization of Aurora-A kinase at specified surface and buried sites by native chemical modification
Rowan, Fiona, Richards, Meirion, Widya, Marcella, Bayliss, Richard, Blagg, Julian
Published in PloS one (05.08.2014)
Published in PloS one (05.08.2014)
Get full text
Journal Article
Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)
Naud, Sébastien, Westwood, Isaac M, Faisal, Amir, Sheldrake, Peter, Bavetsias, Vassilios, Atrash, Butrus, Cheung, Kwai-Ming J, Liu, Manjuan, Hayes, Angela, Schmitt, Jessica, Wood, Amy, Choi, Vanessa, Boxall, Kathy, Mak, Grace, Gurden, Mark, Valenti, Melanie, de Haven Brandon, Alexis, Henley, Alan, Baker, Ross, McAndrew, Craig, Matijssen, Berry, Burke, Rosemary, Hoelder, Swen, Eccles, Suzanne A, Raynaud, Florence I, Linardopoulos, Spiros, van Montfort, Rob L. M, Blagg, Julian
Published in Journal of medicinal chemistry (27.12.2013)
Published in Journal of medicinal chemistry (27.12.2013)
Get full text
Journal Article
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore
Schiemann, Kai, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Poeschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Schneider, Richard, Raynaud, Florence I., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Urbahns, Klaus, Blagg, Julian
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Get full text
Journal Article
Mechanism-based screen for G1/S checkpoint activators identifies a selective activator of EIF2AK3/PERK signalling
Stockwell, Simon R, Platt, Georgina, Barrie, S Elaine, Zoumpoulidou, Georgia, Te Poele, Robert H, Aherne, G Wynne, Wilson, Stuart C, Sheldrake, Peter, McDonald, Edward, Venet, Mathilde, Soudy, Christelle, Elustondo, Frédéric, Rigoreau, Laurent, Blagg, Julian, Workman, Paul, Garrett, Michelle D, Mittnacht, Sibylle
Published in PloS one (12.01.2012)
Published in PloS one (12.01.2012)
Get full text
Journal Article
Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
Whittaker, Steven R., Barlow, Clare, Martin, Mathew P., Mancusi, Caterina, Wagner, Steve, Self, Annette, Barrie, Elaine, Te Poele, Robert, Sharp, Swee, Brown, Nathan, Wilson, Stuart, Jackson, Wayne, Fischer, Peter M., Clarke, Paul A., Walton, Michael I., McDonald, Edward, Blagg, Julian, Noble, Martin, Garrett, Michelle D., Workman, Paul
Published in Molecular oncology (01.03.2018)
Published in Molecular oncology (01.03.2018)
Get full text
Journal Article
A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
EWAN, Kenneth, PAJAK, Bożena, BATTERSBY, Alysia, RAYNAUD, Florence, ALLEN, Nicholas, WILSON, Stephen, LATINKIC, Branko, WORKMAN, Paul, MCDONALD, Edward, BLAGG, Julian, AHERNE, Wynne, DALE, Trevor, STUBBS, Mark, TODD, Helen, BARBEAU, Olivier, QUEVEDO, Camilo, BOTFIELD, Hannah, YOUNG, Rodrigo, RUDDLE, Ruth, SAMUEL, Lee
Published in Cancer research (Chicago, Ill.) (15.07.2010)
Published in Cancer research (Chicago, Ill.) (15.07.2010)
Get full text
Journal Article
Role for the Histone Demethylase KDM4B in Rhabdomyosarcoma via CDK6 and CCNA2: Compensation by KDM4A and Apoptotic Response of Targeting Both KDM4B and KDM4A
Walters, Zoë S, Aladowicz, Ewa, Villarejo-Balcells, Barbara, Nugent, Gary, Selfe, Joanna L, Eve, Paul, Blagg, Julian, Rossanese, Olivia, Shipley, Janet
Published in Cancers (06.04.2021)
Published in Cancers (06.04.2021)
Get full text
Journal Article
Development and evaluation of selective, reversible LSD1 inhibitors derived from fragments
Hitchin, James R., Blagg, Julian, Burke, Rosemary, Burns, Samantha, Cockerill, Mark J., Fairweather, Emma E., Hutton, Colin, Jordan, Allan M., McAndrew, Craig, Mirza, Amin, Mould, Daniel, Thomson, Graeme J., Waddell, Ian, Ogilvie, Donald J.
Published in MedChemComm (01.11.2013)
Published in MedChemComm (01.11.2013)
Get full text
Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (26.10.2015)
Published in Nature chemical biology (26.10.2015)
Get full text
Journal Article
Potent and Selective Nonpeptidic Inhibitors of Procollagen C-Proteinase
Fish, Paul V, Allan, Gillian A, Bailey, Simon, Blagg, Julian, Butt, Richard, Collis, Michael G, Greiling, Doris, James, Kim, Kendall, Jackie, McElroy, Andrew, McCleverty, Dawn, Reed, Charlotte, Webster, Robert, Whitlock, Gavin A
Published in Journal of medicinal chemistry (26.07.2007)
Published in Journal of medicinal chemistry (26.07.2007)
Get full text
Journal Article
Analysis of water patterns in protein kinase binding sites
Barillari, Caterina, Duncan, Anna L., Westwood, Isaac M., Blagg, Julian, van Montfort, Rob L. M.
Published in Proteins, structure, function, and bioinformatics (01.07.2011)
Published in Proteins, structure, function, and bioinformatics (01.07.2011)
Get full text
Journal Article