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Simeone, Roxane, Bobard, Alexandre, Lippmann, Juliane, Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland, Enninga, Jost
Published in PLoS pathogens (01.02.2012)
Published in PLoS pathogens (01.02.2012)
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Structure and dynamics of a mycobacterial type VII secretion system
Bunduc, Catalin M, Fahrenkamp, Dirk, Wald, Jiri, Ummels, Roy, Bitter, Wilbert, Houben, Edith N G, Marlovits, Thomas C
Published in Nature (London) (20.05.2021)
Published in Nature (London) (20.05.2021)
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Towards a new combination therapy for tuberculosis with next generation benzothiazinones
Makarov, Vadim, Lechartier, Benoit, Zhang, Ming, Neres, João, Sar, Astrid M, Raadsen, Susanne A, Hartkoorn, Ruben C, Ryabova, Olga B, Vocat, Anthony, Decosterd, Laurent A, Widmer, Nicolas, Buclin, Thierry, Bitter, Wilbert, Andries, Koen, Pojer, Florence, Dyson, Paul J, Cole, Stewart T
Published in EMBO molecular medicine (01.03.2014)
Published in EMBO molecular medicine (01.03.2014)
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General secretion signal for the mycobacterial type VII secretion pathway
Daleke, Maria H, Ummels, Roy, Bawono, Punto, Heringa, Jaap, Vandenbroucke-Grauls, Christina M. J. E, Luirink, Joen, Bitter, Wilbert
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (10.07.2012)
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The novel antibiotic rhodomyrtone traps membrane proteins in vesicles with increased fluidity
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Published in PLoS pathogens (01.02.2018)
Published in PLoS pathogens (01.02.2018)
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Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation
Bottai, Daria, Di Luca, Mariagrazia, Majlessi, Laleh, Frigui, Wafa, Simeone, Roxane, Sayes, Fadel, Bitter, Wilbert, Brennan, Michael J., Leclerc, Claude, Batoni, Giovanna, Campa, Mario, Brosch, Roland, Esin, Semih
Published in Molecular microbiology (01.03.2012)
Published in Molecular microbiology (01.03.2012)
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Composition of the type VII secretion system membrane complex
Houben, Edith N. G., Bestebroer, Jovanka, Ummels, Roy, Wilson, Louis, Piersma, Sander R., Jiménez, Connie R., Ottenhoff, Tom H. M., Luirink, Joen, Bitter, Wilbert
Published in Molecular microbiology (01.10.2012)
Published in Molecular microbiology (01.10.2012)
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Type VII secretion - mycobacteria show the way
Bitter, Wilbert, Abdallah, Abdallah M, Gey van Pittius, Nicolaas C, DiGiuseppe Champion, Patricia A, Cox, Jeffery, Luirink, Joen, Vandenbroucke-Grauls, Christina M. J. E, Appelmelk, Ben J
Published in Nature reviews. Microbiology (01.11.2007)
Published in Nature reviews. Microbiology (01.11.2007)
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Book Review
Recombinant BCG Expressing ESX-1 of Mycobacterium marinum Combines Low Virulence with Cytosolic Immune Signaling and Improved TB Protection
Gröschel, Matthias I., Sayes, Fadel, Shin, Sung Jae, Frigui, Wafa, Pawlik, Alexandre, Orgeur, Mickael, Canetti, Robin, Honoré, Nadine, Simeone, Roxane, van der Werf, Tjip S., Bitter, Wilbert, Cho, Sang-Nae, Majlessi, Laleh, Brosch, Roland
Published in Cell reports (Cambridge) (14.03.2017)
Published in Cell reports (Cambridge) (14.03.2017)
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Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis
van Alen, Ilona, Aguirre García, Mayra A, Maaskant, Janneke J, Kuijl, Coenraad P, Bitter, Wilbert, Meijer, Annemarie H, Ubbink, Marcellus
Published in Scientific reports (16.09.2023)
Published in Scientific reports (16.09.2023)
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Pneumolysin promotes host cell necroptosis and bacterial competence during pneumococcal meningitis as shown by whole-animal dual RNA-seq
Jim, Kin Ki, Aprianto, Rieza, Koning, Rutger, Domenech, Arnau, Kurushima, Jun, van de Beek, Diederik, Vandenbroucke-Grauls, Christina M.J.E., Bitter, Wilbert, Veening, Jan-Willem
Published in Cell reports (Cambridge) (20.12.2022)
Published in Cell reports (Cambridge) (20.12.2022)
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Essential Role of the ESX-5 Secretion System in Outer Membrane Permeability of Pathogenic Mycobacteria
Ates, Louis S, Ummels, Roy, Commandeur, Susanna, van de Weerd, Robert, van der Weerd, Robert, Sparrius, Marion, Weerdenburg, Eveline, Alber, Marina, Kalscheuer, Rainer, Piersma, Sander R, Abdallah, Abdallah M, Abd El Ghany, Moataz, Abdel-Haleem, Alyaa M, Pain, Arnab, Jiménez, Connie R, Bitter, Wilbert, Houben, Edith N G
Published in PLoS genetics (01.05.2015)
Published in PLoS genetics (01.05.2015)
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PPE and PE_PGRS proteins of Mycobacterium marinum are transported via the type VII secretion system ESX‐5
Abdallah, Abdallah M., Verboom, Theo, Weerdenburg, Eveline M., Gey van Pittius, Nicolaas C., Mahasha, Phetole W., Jiménez, Connie, Parra, Marcela, Cadieux, Nathalie, Brennan, Michael J., Appelmelk, Ben J., Bitter, Wilbert
Published in Molecular microbiology (01.08.2009)
Published in Molecular microbiology (01.08.2009)
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Direct visualization by cryo-EM of the mycobacterial capsular layer: a labile structure containing ESX-1-secreted proteins
Sani, Musa, Houben, Edith N G, Geurtsen, Jeroen, Pierson, Jason, de Punder, Karin, van Zon, Maaike, Wever, Brigitte, Piersma, Sander R, Jiménez, Connie R, Daffé, Mamadou, Appelmelk, Ben J, Bitter, Wilbert, van der Wel, Nicole, Peters, Peter J
Published in PLoS pathogens (01.03.2010)
Published in PLoS pathogens (01.03.2010)
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The extracytoplasmic function sigma factor σ VreI is active during infection and contributes to phosphate starvation-induced virulence of Pseudomonas aeruginosa
Otero-Asman, Joaquín R, Quesada, José M, Jim, Kin K, Ocampo-Sosa, Alain, Civantos, Cristina, Bitter, Wilbert, Llamas, María A
Published in Scientific reports (21.02.2020)
Published in Scientific reports (21.02.2020)
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An anti-tuberculosis compound screen using a zebrafish infection model identifies an aspartyl-tRNA synthetase inhibitor
Habjan, Eva, Ho, Vien Q T, Gallant, James, van Stempvoort, Gunny, Jim, Kin Ki, Kuijl, Coen, Geerke, Daan P, Bitter, Wilbert, Speer, Alexander
Published in Disease models & mechanisms (01.12.2021)
Published in Disease models & mechanisms (01.12.2021)
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EspH is a hypervirulence factor for Mycobacterium marinum and essential for the secretion of the ESX-1 substrates EspE and EspF
Phan, Trang H, van Leeuwen, Lisanne M, Kuijl, Coen, Ummels, Roy, van Stempvoort, Gunny, Rubio-Canalejas, Alba, Piersma, Sander R, Jiménez, Connie R, van der Sar, Astrid M, Houben, Edith N G, Bitter, Wilbert
Published in PLoS pathogens (01.08.2018)
Published in PLoS pathogens (01.08.2018)
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Mycobacteria employ two different mechanisms to cross the blood–brain barrier
Leeuwen, Lisanne M., Boot, Maikel, Kuijl, Coen, Picavet, Daisy I., Stempvoort, Gunny, Pol, Susanne M.A., Vries, Helga E., Wel, Nicole N., Kuip, Martijn, Furth, A. Marceline, Sar, Astrid M., Bitter, Wilbert
Published in Cellular microbiology (01.09.2018)
Published in Cellular microbiology (01.09.2018)
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PPE38-Secretion-Dependent Proteins of M. tuberculosis Alter NF-kB Signalling and Inflammatory Responses in Macrophages
Gallant, James, Heunis, Tiaan, Beltran, Caroline, Schildermans, Karin, Bruijns, Sven, Mertens, Inge, Bitter, Wilbert, Sampson, Samantha L
Published in Frontiers in immunology (02.07.2021)
Published in Frontiers in immunology (02.07.2021)
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RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection
Ates, Louis S, Sayes, Fadel, Frigui, Wafa, Ummels, Roy, Damen, Merel P M, Bottai, Daria, Behr, Marcel A, van Heijst, Jeroen W J, Bitter, Wilbert, Majlessi, Laleh, Brosch, Roland
Published in PLoS pathogens (18.06.2018)
Published in PLoS pathogens (18.06.2018)
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