Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients
Shapiro, Amy D., Ragni, Margaret V., Valentino, Leonard A., Key, Nigel S., Josephson, Neil C., Powell, Jerry S., Cheng, Gregory, Thompson, Arthur R., Goyal, Jaya, Tubridy, Karen L., Peters, Robert T., Dumont, Jennifer A., Euwart, Donald, Li, Lian, Hallén, Bengt, Gozzi, Peter, Bitonti, Alan J., Jiang, Haiyan, Luk, Alvin, Pierce, Glenn F.
Published in Blood (19.01.2012)
Published in Blood (19.01.2012)
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Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs
Dumont, Jennifer A., Liu, Tongyao, Low, Susan C., Zhang, Xin, Kamphaus, George, Sakorafas, Paul, Fraley, Cara, Drager, Douglas, Reidy, Thomas, McCue, Justin, Franck, Helen W.G., Merricks, Elizabeth P., Nichols, Timothy C., Bitonti, Alan J., Pierce, Glenn F., Jiang, Haiyan
Published in Blood (29.03.2012)
Published in Blood (29.03.2012)
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Prolonged activity of factor IX as a monomeric Fc fusion protein
Peters, Robert T., Low, Susan C., Kamphaus, George D., Dumont, Jennifer A., Amari, John V., Lu, Qi, Zarbis-Papastoitsis, Greg, Reidy, Thomas J., Merricks, Elizabeth P., Nichols, Timothy C., Bitonti, Alan J.
Published in Blood (11.03.2010)
Published in Blood (11.03.2010)
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Reduction of IgG in Nonhuman Primates by a Peptide Antagonist of the Neonatal Fc Receptor FcRn
Mezo, Adam R., McDonnell, Kevin A., Hehir, Cristina A. Tan, Low, Susan C., Palombella, Vito J., Stattel, James M., Kamphaus, George D., Fraley, Cara, Zhang, Yixia, Dumont, Jennifer A., Bitonti, Alan J.
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2008)
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Pulmonary Delivery of an Erythropoietin Fc Fusion Protein in Non-Human Primates through an Immunoglobulin Transport Pathway
Bitonti, Alan J., Dumont, Jennifer A., Low, Susan C., Peters, Robert T., Kropp, Keith E., Palombella, Vito J., Stattel, James M., Lu, Yichun, Tan, Cristina A., Song, Jeffrey J., Garcia, Ana Maria, Simister, Neil E., Spiekermann, Gerburg M., Lencer, Wayne I., Blumberg, Richard S., Bjorkman, Pamela J.
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2004)
Published in Proceedings of the National Academy of Sciences - PNAS (29.06.2004)
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Recombinant Factor IX Fc Fusion Protein Maintains Full Procoagulant Properties and Exhibits Prolonged Efficacy in Hemophilia B Mice
Toby, Garabet G, Liu, Tongyao, Buyue, Yang, Zhang, Xin, Bitonti, Alan J, Pierce, Glenn F, Sommer, Jurg M, Jiang, Haiyan, Peters, Robert T
Published in PloS one (03.02.2016)
Published in PloS one (03.02.2016)
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Fully human monoclonal antibody inhibitors of the neonatal fc receptor reduce circulating IgG in non-human primates
Nixon, Andrew E, Chen, Jie, Sexton, Daniel J, Muruganandam, Arumugam, Bitonti, Alan J, Dumont, Jennifer, Viswanathan, Malini, Martik, Diana, Wassaf, Dina, Mezo, Adam, Wood, Clive R, Biedenkapp, Joseph C, TenHoor, Chris
Published in Frontiers in immunology (23.04.2015)
Published in Frontiers in immunology (23.04.2015)
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Fully human monoclonal antibody inhibitors of the neonatal Fc receptor (FcRn) reduce circulating IgG in nonhuman primates
Andrew E Nixon, Jie eChen, Daniel J Sexton, Arumugam eMuruganandam, Alan J Bitonti, Jennifer eDumont, Malini eViswanathan, Diana eMartik, Dina eWassaf, Adam eMezo, Clive R Wood, Joseph C Biedenkapp, Christopher eTenHoor
Published in Frontiers in immunology (01.04.2015)
Published in Frontiers in immunology (01.04.2015)
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Atrial Natriuretic Peptide-Fc, ANP-Fc, Fusion Proteins: Semisynthesis, In Vitro Activity and Pharmacokinetics in Rats
Mezo, Adam R, McDonnell, Kevin A, Low, Susan C, Song, Jeff, Reidy, Tom J, Lu, Qi, Amari, John V, Hoehn, Todd, Peters, Robert T, Dumont, Jennifer, Bitonti, Alan J
Published in Bioconjugate chemistry (21.03.2012)
Published in Bioconjugate chemistry (21.03.2012)
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Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway
DUMONT, Jennifer A, BITONTI, Alan J, CLARK, Darren, EVANS, Sean, PICKFORD, Matthew, NEWMAN, Stephen P
Published in Journal of aerosol medicine (01.09.2005)
Published in Journal of aerosol medicine (01.09.2005)
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FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF
SUSAN LOW, BYRON MCKINNEY, MATT OTTMER, LI LIAN, HAIYAN JIANG, JURG SOMMER, ROBERT PETERS, KAREN NUGENT, GLENN PIERCE, BITONTI ALAN J, ALVIN LUK, JENNIFER A DUMONT
Year of Publication 27.09.2023
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Year of Publication 27.09.2023
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FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF
SUSAN LOW, BYRON MCKINNEY, MATT OTTMER, LI LIAN, HAIYAN JIANG, JURG SOMMER, ROBERT PETERS, KAREN NUGENT, GLENN PIERCE, BITONTI ALAN J, ALVIN LUK, JENNIFER A DUMONT
Year of Publication 11.01.2022
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Year of Publication 11.01.2022
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Crystal Structure of Human Cyclin-Dependent Kinase 2 in Complex with the Adenine-Derived Inhibitor H717
Dreyer, Matthias K, Borcherding, David R, Dumont, Jennifer A, Peet, Norton P, Tsay, Joseph T, Wright, Paul S, Bitonti, Alan J, Shen, Jian, Kim, Sung-Hou
Published in Journal of medicinal chemistry (15.02.2001)
Published in Journal of medicinal chemistry (15.02.2001)
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FACTOR VIII-Fc CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF
SUSAN LOW, BYRON MCKINNEY, MATT OTTMER, LI LIAN, HAIYAN JIANG, JURG SOMMER, ROBERT PETERS, KAREN NUGENT, GLENN PIERCE, BITONTI ALAN J, ALVIN LUK, JENNIFER A DUMONT
Year of Publication 06.02.2020
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Year of Publication 06.02.2020
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ANTIBODIES AGAINST FCRN AND USE THEREOF
LIU LIMING, TENHOOR CHRISTOPHER, LADNER ROBERT CHARLES, DUMONT JENNIFER, MURUGANANDAM ARUMUGAM, BITONTI ALAN J, STATTEL JAMES, SATO AARON, WOOD CLIVE, MCDONNELL KEVIN
Year of Publication 09.09.2019
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Year of Publication 09.09.2019
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IMMUNOGLOBULIN CHIMERIC MONOMER-DIMER HYBRIDS
RIVERA DANIEL S, PETERS ROBERT T, MEZO ADAM R, STATTEL JAMES M, BITONTI ALAN J, LOW SUSAN C
Year of Publication 16.08.2018
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Year of Publication 16.08.2018
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FACTOR VIII CHIMERIC AND HYBRID POLYPEPTIDES, AND METHODS OF USE THEREOF
SUSAN LOW, BYRON MCKINNEY, MATT OTTMER, LI LIAN, HAIYAN JIANG, JURG SOMMER, ROBERT PETERS, KAREN NUGENT, GLENN PIERCE, BITONTI ALAN J, ALVIN LUK, JENNIFER A DUMONT
Year of Publication 28.03.2019
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Year of Publication 28.03.2019
Patent