Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts
Wright, Charles W, Li, Naomi, Shaffer, Lynsey, Hill, Armetta, Boyer, Nicolas, Alves, Stephen E, Venkataraman, Sriraman, Biswas, Kaustav, Lieberman, Linda A, Mohammadi, Sina
Published in Scientific reports (29.09.2023)
Published in Scientific reports (29.09.2023)
Get full text
Journal Article
Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V
Moyer, Bryan D, Murray, Justin K, Ligutti, Joseph, Andrews, Kristin, Favreau, Philippe, Jordan, John B, Lee, Josie H, Liu, Dong, Long, Jason, Sham, Kelvin, Shi, Licheng, Stöcklin, Reto, Wu, Bin, Yin, Ruoyuan, Yu, Violeta, Zou, Anruo, Biswas, Kaustav, Miranda, Les P
Published in PloS one (01.05.2018)
Published in PloS one (01.05.2018)
Get full text
Journal Article
Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists
Chandramohan, Arun, Josien, Hubert, Yuen, Tsz Ying, Duggal, Ruchia, Spiegelberg, Diana, Yan, Lin, Juang, Yu-Chi Angela, Ge, Lan, Aronica, Pietro G, Kaan, Hung Yi Kristal, Lim, Yee Hwee, Peier, Andrea, Sherborne, Brad, Hochman, Jerome, Lin, Songnian, Biswas, Kaustav, Nestor, Marika, Verma, Chandra S, Lane, David P, Sawyer, Tomi K, Garbaccio, Robert, Henry, Brian, Kannan, Srinivasaraghavan, Brown, Christopher J, Johannes, Charles W, Partridge, Anthony W
Published in Nature communications (12.01.2024)
Published in Nature communications (12.01.2024)
Get full text
Journal Article
Discovery of TRPM8 Antagonist (S)‑6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine
Horne, Daniel B, Biswas, Kaustav, Brown, James, Bartberger, Michael D, Clarine, Jeffrey, Davis, Carl D, Gore, Vijay K, Harried, Scott, Horner, Michelle, Kaller, Matthew R, Lehto, Sonya G, Liu, Qingyian, Ma, Vu V, Monenschein, Holger, Nguyen, Thomas T, Yuan, Chester C, Youngblood, Beth D, Zhang, Maosheng, Zhong, Wenge, Allen, Jennifer R, Chen, Jian Jeffrey, Gavva, Narender R
Published in Journal of medicinal chemistry (27.09.2018)
Published in Journal of medicinal chemistry (27.09.2018)
Get full text
Journal Article
Discovery of Clinical Candidate 1‑(4-(3-(4-(1H‑Benzo[d]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)
Hu, Essa, Chen, Ning, Bourbeau, Matthew P, Harrington, Paul E, Biswas, Kaustav, Kunz, Roxanne K, Andrews, Kristin L, Chmait, Samer, Zhao, Xiaoning, Davis, Carl, Ma, Ji, Shi, Jianxia, Lester-Zeiner, Dianna, Danao, Jean, Able, Jessica, Cueva, Madelyn, Talreja, Santosh, Kornecook, Thomas, Chen, Hang, Porter, Amy, Hungate, Randall, Treanor, James, Allen, Jennifer R
Published in Journal of medicinal chemistry (14.08.2014)
Published in Journal of medicinal chemistry (14.08.2014)
Get full text
Journal Article
Identification of Antibody and Small Molecule Antagonists of Ferroportin-Hepcidin Interaction
Ross, Sandra L, Biswas, Kaustav, Rottman, James, Allen, Jennifer R, Long, Jason, Miranda, Les P, Winters, Aaron, Arvedson, Tara L
Published in Frontiers in pharmacology (21.11.2017)
Published in Frontiers in pharmacology (21.11.2017)
Get full text
Journal Article
Discovery of Potent, Orally Bioavailable Phthalazinone Bradykinin B1 Receptor Antagonists
Biswas, Kaustav, Peterkin, Tanya A. N, Bryan, Marian C, Arik, Leyla, Lehto, Sonya G, Sun, Hong, Hsieh, Feng-Yin, Xu, Cen, Fremeau, Robert T, Allen, Jennifer R
Published in Journal of medicinal chemistry (27.10.2011)
Published in Journal of medicinal chemistry (27.10.2011)
Get full text
Journal Article
Highly Concise Routes to Epothilones: The Total Synthesis and Evaluation of Epothilone 490
Biswas, Kaustav, Lin, Hong, Njardarson, Jon T, Chappell, Mark D, Chou, Ting-Chao, Guan, Yongbiao, Tong, William P, He, Lifeng, Horwitz, Susan B, Danishefsky, Samuel J
Published in Journal of the American Chemical Society (21.08.2002)
Published in Journal of the American Chemical Society (21.08.2002)
Get full text
Journal Article
HEAD AND NECK MALIGNANCY IN YOUNG FEMALES - OUR EXPERIENCE
Mondal, Satadal, Saha, Jayanta, Biswas, Kaustav Das, Sinha, Ramanuj
Published in Journal of evolution of medical and dental sciences (20.01.2014)
Published in Journal of evolution of medical and dental sciences (20.01.2014)
Get full text
Journal Article
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
Liang, Rui, Yan, Lin, Loebach, Jennifer, Ge, Min, Uozumi, Yasuhiro, Sekanina, Klara, Horan, Nina, Gildersleeve, Jeff, Thompson, Chris, Smith, Andri, Biswas, Kaustav, Still, W. Clark, Kahne, Daniel
Published in Science (American Association for the Advancement of Science) (29.11.1996)
Published in Science (American Association for the Advancement of Science) (29.11.1996)
Get full text
Journal Article
On the Introduction of a Trifluoromethyl Substituent in the Epothilone Setting: Chemical Issues Related to Ring Forming Olefin Metathesis and Earliest Biological Findings
Rivkin, Alexey, Biswas, Kaustav, Chou, Ting-Chao, Danishefsky, Samuel J
Published in Organic letters (14.11.2002)
Published in Organic letters (14.11.2002)
Get full text
Journal Article
The Epothilones, Eleutherobins, and Related Types of Molecules
STACHEL, Shawn J, BISWAS, Kaustav, DANISHEFSKY, Samuel J
Published in Current pharmaceutical design (01.09.2001)
Published in Current pharmaceutical design (01.09.2001)
Get full text
Journal Article
Accelerated Identification of Cell Active KRAS Inhibitory Macrocyclic Peptides using Mixture Libraries and Automated Ligand Identification System (ALIS) Technology
Garrigou, Michael, Sauvagnat, Bérengère, Duggal, Ruchia, Boo, Nicole, Gopal, Pooja, Johnston, Jennifer M., Partridge, Anthony, Sawyer, Tomi, Biswas, Kaustav, Boyer, Nicolas
Published in Journal of medicinal chemistry (14.07.2022)
Published in Journal of medicinal chemistry (14.07.2022)
Get full text
Journal Article
Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the Na(V)1.7 Inhibitory Peptide GpTx-1
Murray, Justin K., Long, Jason, Zou, Anruo, Ligutti, Joseph, Andrews, Kristin L., Poppe, Leszek, Biswas, Kaustav, Moyer, Bryan D., McDonough, Stefan I., Miranda, Les P.
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
Get full text
Journal Article
Rapid label-free cell-based Approach Membrane Permeability Assay using MALDI-hydrogen-deuterium exchange mass spectrometry for peptides
Makarov, Alexey A., Jiang, Yuan, Sondey, Christopher, Zhang, Minjia, Mansueto, My Sam, Pirrone, Gregory F., Huang, Chunhui, Biswas, Kaustav, Duggal, Ruchia, Al-Sayah, Mohammad Ahmed, Regalado, Erik L., Mangion, Ian
Published in Analytica chimica acta (08.09.2022)
Published in Analytica chimica acta (08.09.2022)
Get full text
Journal Article
Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx‑1
Murray, Justin K, Long, Jason, Zou, Anruo, Ligutti, Joseph, Andrews, Kristin L, Poppe, Leszek, Biswas, Kaustav, Moyer, Bryan D, McDonough, Stefan I, Miranda, Les P
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
Get full text
Journal Article
NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay
Peier, Andrea, Ge, Lan, Boyer, Nicolas, Frost, John, Duggal, Ruchia, Biswas, Kaustav, Edmondson, Scott, Hermes, Jeffrey D, Yan, Lin, Zimprich, Chad, Sadruddin, Ahmad, Kristal Kaan, Hung Yi, Chandramohan, Arun, Brown, Christopher J, Thean, Dawn, Lee, Xue Er, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Johannes, Charles W, Lane, David P, Sherborne, Brad, Corona, Cesear, Robers, Matthew B, Sawyer, Tomi K, Partridge, Anthony W
Published in ACS chemical biology (19.02.2021)
Published in ACS chemical biology (19.02.2021)
Get full text
Journal Article
Unfolded Protein Response in Cancer: IRE1a Inhibition by Selective Kinase Ligands Does Not Impair Tumor Cell Viability
Harrington, Paul E., Biswas, Kaustav, Malwitz, David, Tasker, Andrew S., Mohr, Christopher, Andrews, Kristin L., Dellamaggiore, Ken, Kendall, Richard, Beckmann, Holger, Jaeckel, Peter, Materna-Reichelt, Silvia, Allen, Jennifer R., Lipford, J. Russell
Published in ACS medicinal chemistry letters (01.01.2015)
Published in ACS medicinal chemistry letters (01.01.2015)
Get full text
Journal Article
Discovery of Tarantula Venom-Derived NaV1.7-Inhibitory JzTx‑V Peptide 5‑Br-Trp24 Analogue AM-6120 with Systemic Block of Histamine-Induced Pruritis
Wu, Bin, Murray, Justin K, Andrews, Kristin L, Sham, Kelvin, Long, Jason, Aral, Jennifer, Ligutti, Joseph, Amagasu, Shanti, Liu, Dong, Zou, Anruo, Min, Xiaoshan, Wang, Zhulun, Ilch, Christopher P, Kornecook, Thomas J, Lin, Min-Hwa Jasmine, Be, Xuhai, Miranda, Les P, Moyer, Bryan D, Biswas, Kaustav
Published in Journal of medicinal chemistry (08.11.2018)
Published in Journal of medicinal chemistry (08.11.2018)
Get full text
Journal Article
Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application to Mdm2/X dual antagonists
Chandramohan, Arun, Josien, Hubert, Yuen, Tsz Ying, Duggal, Ruchia, Spiegelberg, Diana, Yan, Lin, Angela Juang, Yu-Chi, Ge, Lan, Aronica, Pietro, Kaan, Kristal, Lim, Yee Hwee, Peier, Andrea, Sherborne, Brad, Hochman, Jerome, Lin, Songnian, Biswas, Kaustav, Henry, Brian, Nestor, Marika, Verma, Chandra S, Lane, David, Sawyer, Tomi, Garbaccio, Robert, Kannan, Srinivasaraghavan, Brown, Christopher J., Johannes, Charles W, Partridge, Anthony William
Published in Nature communications (26.02.2023)
Published in Nature communications (26.02.2023)
Get full text
Journal Article