Innovations, challenges, and minimal information for standardization of humanized mice
Stripecke, Renata, Münz, Christian, Schuringa, Jan Jacob, Bissig, Karl‐Dimiter, Soper, Brian, Meeham, Terrence, Yao, Li‐Chin, Di Santo, James P, Brehm, Michael, Rodriguez, Estefania, Wege, Anja Kathrin, Bonnet, Dominique, Guionaud, Silvia, Howard, Kristina E, Kitchen, Scott, Klein, Florian, Saeb‐Parsy, Kourosh, Sam, Johannes, Sharma, Amar Deep, Trumpp, Andreas, Trusolino, Livio, Bult, Carol, Shultz, Leonard
Published in EMBO molecular medicine (07.07.2020)
Published in EMBO molecular medicine (07.07.2020)
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Journal Article
The camKK2/camKIV relay is an essential regulator of hepatic cancer
Lin, Fumin, Marcelo, Kathrina L., Rajapakshe, Kimal, Coarfa, Cristian, Dean, Adam, Wilganowski, Nathaniel, Robinson, Holly, Sevick, Eva, Bissig, Karl‐Dimiter, Goldie, Lauren C., Means, Anthony R., York, Brian
Published in Hepatology (Baltimore, Md.) (01.08.2015)
Published in Hepatology (Baltimore, Md.) (01.08.2015)
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Journal Article
Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia
Pankowicz, Francis P., Barzi, Mercedes, Legras, Xavier, Hubert, Leroy, Mi, Tian, Tomolonis, Julie A., Ravishankar, Milan, Sun, Qin, Yang, Diane, Borowiak, Malgorzata, Sumazin, Pavel, Elsea, Sarah H., Bissig-Choisat, Beatrice, Bissig, Karl-Dimiter
Published in Nature communications (30.08.2016)
Published in Nature communications (30.08.2016)
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Journal Article
A High Proliferation Rate Is Required for Cell Reprogramming and Maintenance of Human Embryonic Stem Cell Identity
Ruiz, Sergio, Panopoulos, Athanasia D., Herrerías, Aída, Bissig, Karl-Dimiter, Lutz, Margaret, Berggren, W. Travis, Verma, Inder M., Izpisua Belmonte, Juan Carlos
Published in Current biology (11.01.2011)
Published in Current biology (11.01.2011)
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Journal Article
P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity
Bissig, Karl-Dimiter, Han, Weiguo, Barzi, Mercedes, Kovalchuk, Nataliia, Ding, Liang, Fan, Xiaoyu, Pankowicz, Francis P, Zhang, Qing-Yu, Ding, Xinxin
Published in Drug metabolism and disposition (01.11.2018)
Published in Drug metabolism and disposition (01.11.2018)
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Journal Article
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
Bissig, Karl-Dimiter, Wieland, Stefan F, Tran, Phu, Isogawa, Masanori, Le, Tam T, Chisari, Francis V, Verma, Inder M
Published in The Journal of clinical investigation (01.03.2010)
Published in The Journal of clinical investigation (01.03.2010)
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Journal Article
CRISPR/Cas9: at the cutting edge of hepatology
Pankowicz, Francis P, Jarrett, Kelsey E, Lagor, William R, Bissig, Karl-Dimiter
Published in Gut (01.07.2017)
Published in Gut (01.07.2017)
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Journal Article
Book Review
A humanized mouse model for adeno-associated viral gene therapy
Barzi, Mercedes, Chen, Tong, Gonzalez, Trevor J., Pankowicz, Francis P., Oh, Seh Hoon, Streff, Helen L., Rosales, Alan, Ma, Yunhan, Collias, Sabrina, Woodfield, Sarah E., Diehl, Anna Mae, Vasudevan, Sanjeev A., Galvan, Thao N., Goss, John, Gersbach, Charles A., Bissig-Choisat, Beatrice, Asokan, Aravind, Bissig, Karl-Dimiter
Published in Nature communications (04.03.2024)
Published in Nature communications (04.03.2024)
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Journal Article
Generation of model tissues with dendritic vascular networks via sacrificial laser-sintered carbohydrate templates
Kinstlinger, Ian S., Saxton, Sarah H., Calderon, Gisele A., Ruiz, Karen Vasquez, Yalacki, David R., Deme, Palvasha R., Rosenkrantz, Jessica E., Louis-Rosenberg, Jesse D., Johansson, Fredrik, Janson, Kevin D., Sazer, Daniel W., Panchavati, Saarang S., Bissig, Karl-Dimiter, Stevens, Kelly R., Miller, Jordan S.
Published in Nature biomedical engineering (01.09.2020)
Published in Nature biomedical engineering (01.09.2020)
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Journal Article
A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism
Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Published in Nature communications (28.06.2017)
Published in Nature communications (28.06.2017)
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Journal Article
Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells
Velasquez-Mao, Aaron J, Tsao, Christopher J M, Monroe, Madeline N, Legras, Xavier, Bissig-Choisat, Beatrice, Bissig, Karl-Dimiter, Ruano, Rodrigo, Jacot, Jeffrey G
Published in PloS one (17.05.2017)
Published in PloS one (17.05.2017)
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Journal Article
Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model
Bissig-Choisat, Beatrice, Wang, Lili, Legras, Xavier, Saha, Pradip K., Chen, Leon, Bell, Peter, Pankowicz, Francis P., Hill, Matthew C., Barzi, Mercedes, Leyton, Claudia Kettlun, Leung, Hon-Chiu Eastwood, Kruse, Robert L., Himes, Ryan W., Goss, John A., Wilson, James M., Chan, Lawrence, Lagor, William R., Bissig, Karl-Dimiter
Published in Nature communications (17.06.2015)
Published in Nature communications (17.06.2015)
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Journal Article
Using CRISPR/Cas9 to model human liver disease
Alves-Bezerra, Michele, Furey, Nika, Johnson, Collin G., Bissig, Karl-Dimiter
Published in JHEP reports (01.11.2019)
Published in JHEP reports (01.11.2019)
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Journal Article
A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma
Woodfield, Sarah E., Shi, Yan, Patel, Roma H., Jin, Jingling, Major, Angela, Sarabia, Stephen F., Starosolski, Zbigniew, Zorman, Barry, Gupta, Siddharth S., Chen, Zhenghu, Ibarra, Aryana M., Bissig, Karl-Dimiter, Ghaghada, Ketan B., Sumazin, Pavel, López-Terrada, Dolores, Vasudevan, Sanjeev A.
Published in Scientific reports (19.12.2017)
Published in Scientific reports (19.12.2017)
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Journal Article
Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex
Minor, Marissa M, Hollinger, F Blaine, McNees, Adrienne L, Jung, Sung Yun, Jain, Antrix, Hyser, Joseph M, Bissig, Karl-Dimiter, Slagle, Betty L
Published in Cells (Basel, Switzerland) (30.03.2020)
Published in Cells (Basel, Switzerland) (30.03.2020)
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Journal Article
Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing
Johnson, Collin G, Chen, Tong, Furey, Nika, Hemmingsen, Madeline G, Bissig, Karl-Dimiter
Published in Current protocols in molecular biology (Print) (01.03.2020)
Published in Current protocols in molecular biology (Print) (01.03.2020)
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Journal Article
A human liver chimeric mouse model for non-alcoholic fatty liver disease
Bissig-Choisat, Beatrice, Alves-Bezerra, Michele, Zorman, Barry, Ochsner, Scott A., Barzi, Mercedes, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Dean, Adam M., York, Robert B., Galvan, N. Thao N., Goss, John, Lagor, William R., Moore, David D., Cohen, David E., McKenna, Neil J., Sumazin, Pavel, Bissig, Karl-Dimiter
Published in JHEP reports (01.06.2021)
Published in JHEP reports (01.06.2021)
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Journal Article
Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism
Barzi, Mercedes, Pankowicz, Francis P., Zorman, Barry, Liu, Xing, Legras, Xavier, Yang, Diane, Borowiak, Malgorzata, Bissig-Choisat, Beatrice, Sumazin, Pavel, Li, Feng, Bissig, Karl-Dimiter
Published in Nature communications (17.10.2017)
Published in Nature communications (17.10.2017)
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Journal Article
PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma
Valanejad, Leila, Cast, Ashley, Wright, Mary, Bissig, Karl-Dimiter, Karns, Rebekah, Weirauch, Matthew T., Timchenko, Nikolai
Published in Communications biology (01.01.2018)
Published in Communications biology (01.01.2018)
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