Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA
Schlegel, Mark K, Foster, Donald J, Kel’in, Alexander V, Zlatev, Ivan, Bisbe, Anna, Jayaraman, Muthusamy, Lackey, Jeremy G, Rajeev, Kallanthottathil G, Charissé, Klaus, Harp, Joel, Pallan, Pradeep S, Maier, Martin A, Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (28.06.2017)
Published in Journal of the American Chemical Society (28.06.2017)
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4′‑C‑Methoxy-2′-deoxy-2′-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing
Malek-Adamian, Elise, Guenther, Dale C, Matsuda, Shigeo, Martínez-Montero, Saúl, Zlatev, Ivan, Harp, Joel, Burai Patrascu, Mihai, Foster, Donald J, Fakhoury, Johans, Perkins, Lydia, Moitessier, Nicolas, Manoharan, Rajar M, Taneja, Nate, Bisbe, Anna, Charisse, Klaus, Maier, Martin, Rajeev, Kallanthottathil G, Egli, Martin, Manoharan, Muthiah, Damha, Masad J
Published in Journal of the American Chemical Society (18.10.2017)
Published in Journal of the American Chemical Society (18.10.2017)
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Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
Harp, Joel M, Guenther, Dale C, Bisbe, Anna, Perkins, Lydia, Matsuda, Shigeo, Bommineni, Gopal R, Zlatev, Ivan, Foster, Donald J, Taneja, Nate, Charisse, Klaus, Maier, Martin A, Rajeev, Kallanthottathil G, Manoharan, Muthiah, Egli, Martin
Published in Nucleic acids research (19.09.2018)
Published in Nucleic acids research (19.09.2018)
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RNAi-mediated rheostat for dynamic control of AAV-delivered transgenes
Subramanian, Megha, McIninch, James, Zlatev, Ivan, Schlegel, Mark K., Kaittanis, Charalambos, Nguyen, Tuyen, Agarwal, Saket, Racie, Timothy, Alvarado, Martha Arbaiza, Wassarman, Kelly, Collins, Thomas S., Chickering, Tyler, Brown, Christopher R., Schmidt, Karyn, Castoreno, Adam B., Shulga-Morskaya, Svetlana, Stamenova, Elena, Buckowing, Kira, Berman, Daniel, Barry, Joseph D., Bisbe, Anna, Maier, Martin A., Fitzgerald, Kevin, Jadhav, Vasant
Published in Nature communications (08.04.2023)
Published in Nature communications (08.04.2023)
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Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′‑C‑Methyl Pyrimidine-Modified Oligonucleotides
Kel′in, Alexander V, Zlatev, Ivan, Harp, Joel, Jayaraman, Muthusamy, Bisbe, Anna, O′Shea, Jonathan, Taneja, Nate, Manoharan, Rajar M, Khan, Saeed, Charisse, Klaus, Maier, Martin A, Egli, Martin, Rajeev, Kallanthottathil G, Manoharan, Muthiah
Published in Journal of organic chemistry (18.03.2016)
Published in Journal of organic chemistry (18.03.2016)
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Journal Article
Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology in vivo
Jahns, Hartmut, Taneja, Nate, Willoughby, Jennifer L S, Akabane-Nakata, Masaaki, Brown, Christopher R, Nguyen, Tuyen, Bisbe, Anna, Matsuda, Shigeo, Hettinger, Matt, Manoharan, Rajar M, Rajeev, Kallanthottathil G, Maier, Martin A, Zlatev, Ivan, Charisse, Klaus, Egli, Martin, Manoharan, Muthiah
Published in Nucleic acids research (22.02.2022)
Published in Nucleic acids research (22.02.2022)
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Journal Article
Shorter Is Better: The a-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu, Datta, Dhrubajyoti, Mikami, Atsushi, Woods, Lauren, Harp, Joel M., Gilbert, Jason A., Bisbe, Anna, Manoharan, Rajar M., Kim, MaryBeth, Theile, Christopher S., Guenther, Dale C., Jiang, Yongfeng, Agarwal, Saket, Maganti, Rajanikanth, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Rajeev, Kallanthottathil G., Castoreno, Adam, Egli, Martin, Janas, Maja M., Egli, Martin, Chaput, John C., Manoharan, Muthiah
Published in Journal of the American Chemical Society (28.08.2023)
Published in Journal of the American Chemical Society (28.08.2023)
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Evolving Pattern Improves the IMWG 2/20/20 Classification for Patients with Smoldering Multiple Myeloma
Rodríguez-Lobato, Luis Gerardo, de Daniel i Bisbe, Anna, Tovar, Natalia, Jiménez-Segura, Raquel, Cibeira, M. Teresa, Moreno, David F., Oliver-Caldes, Aina, Martínez-Roca, Alexandra, Lozano, Ester, Bladé Creixenti, Joan, Rosinol Dachs, Laura, Fernandez de Larrea, Carlos
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Metabolically Stable Anomeric Linkages Containing GalNAc–siRNA Conjugates: An Interplay among ASGPR, Glycosidase, and RISC Pathways
Kandasamy, Pachamuthu, Mori, Shohei, Matsuda, Shigeo, Erande, Namrata, Datta, Dhrubajyoti, Willoughby, Jennifer L. S., Taneja, Nate, O’Shea, Jonathan, Bisbe, Anna, Manoharan, Rajar M., Yucius, Kristina, Nguyen, Tuyen, Indrakanti, Ramesh, Gupta, Swati, Gilbert, Jason A., Racie, Tim, Chan, Amy, Liu, Ju, Hutabarat, Renta, Nair, Jayaprakash K., Charisse, Klaus, Maier, Martin A., Rajeev, Kallanthottathil G., Egli, Martin, Manoharan, Muthiah
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Small circular interfering RNAs (sciRNAs) as a potent therapeutic platform for gene-silencing
Jahns, Hartmut, Degaonkar, Rohan, Podbevsek, Peter, Gupta, Swati, Bisbe, Anna, Aluri, Krishna, Szeto, John, Kumar, Pawan, LeBlanc, Sarah, Racie, Tim, Brown, Christopher R, Castoreno, Adam, Guenther, Dale C, Jadhav, Vasant, Maier, Martin A, Plavec, Janez, Egli, Martin, Manoharan, Muthiah, Zlatev, Ivan
Published in Nucleic acids research (11.10.2021)
Published in Nucleic acids research (11.10.2021)
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RNAi knockdown of microtubule‐associated protein Tau prevents axonal damage and clears pre‐existing Tau aggregates in P301S transgenic tauopathy model mice
Haines, Jeffery D, Farley, Jonathan, Gannon, Sean, Schlegel, Mark, Castoreno, Adam, Bisbe, Anna, Zlatev, Ivan, Rollins, Jeff, Bostwick, Bret, Avbersek, Andreja, Brown, Kirk, Macdonald, Lynn, Gao, Min, Anderson, Matthew
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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An Investigational RNAi Therapeutic for Tau Lowering
Farley, Jonathan, Haines, Jeffery D, Gannon, Sean, Nguyen, Tuyen, Abbott, Stephen, Darcy, Justin, Tymon, Roxanne, Cha, Diana, Schlegel, Mark, Castoreno, Adam, Bisbe, Anna, Zlatev, Ivan, Rollins, Jeff, Bostwick, Bret, Avbersek, Andreja, Macdonald, Lynn, Gao, Min, Anderson, Matthew, Brown, Kirk
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
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Shorter Is Better: The α‑(l)‑Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs
Matsuda, Shigeo, Bala, Saikat, Liao, Jen-Yu, Datta, Dhrubajyoti, Mikami, Atsushi, Woods, Lauren, Harp, Joel M., Gilbert, Jason A., Bisbe, Anna, Manoharan, Rajar M., Kim, MaryBeth, Theile, Christopher S., Guenther, Dale C., Jiang, Yongfeng, Agarwal, Saket, Maganti, Rajanikanth, Schlegel, Mark K., Zlatev, Ivan, Charisse, Klaus, Rajeev, Kallanthottathil G., Castoreno, Adam, Maier, Martin, Janas, Maja M., Egli, Martin, Chaput, John C., Manoharan, Muthiah
Published in Journal of the American Chemical Society (13.09.2023)
Published in Journal of the American Chemical Society (13.09.2023)
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Bicistronic CAR T Cell Against CD229 and BCMA Effectively Controls Multiple Myeloma
Rodríguez-Lobato, Luis Gerardo, Cardus, Oriol, Mañe-Pujol, Joan, Battram, Anthony M, Pérez-Amill, Lorena, Calderón, Hugo, Martin-Antonio, Beatriz, Oliver-Caldes, Aina, Garcias-López, Agnès, Lozano, Ester, Moreno, David F., Ortiz-Maldonado, Valentín, Salas, Maria Queralt, de Daniel i Bisbe, Anna, Tovar, Natalia, Jiménez-Segura, Raquel, Cibeira, M. Teresa, Rosinol Dachs, Laura, Bladé Creixenti, Joan, Juan, Manel, Urbano-Ispizua, Álvaro, Engel, Pablo, Fernandez de Larrea, Carlos
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Role of a “Magic” Methyl: 2′-Deoxy-2′-α-F-2′-β‑C‑methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5′-Phosphate Mimics and Mitigation of Off-Target Effects
Guenther, Dale C., Mori, Shohei, Matsuda, Shigeo, Gilbert, Jason A., Willoughby, Jennifer L. S., Hyde, Sarah, Bisbe, Anna, Jiang, Yongfeng, Agarwal, Saket, Madaoui, Mimouna, Janas, Maja M., Charisse, Klaus, Maier, Martin A., Egli, Martin, Manoharan, Muthiah
Published in Journal of the American Chemical Society (17.08.2022)
Published in Journal of the American Chemical Society (17.08.2022)
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NAIR JAYAPRAKASH K, MAIER MARTIN A, KEL'IN ALEXANDER V, TANG CHENG, BISBE ANNA, PIERSON JUSTIN M
Year of Publication 26.09.2023
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Year of Publication 26.09.2023
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P-120 Impact of exclusion from clinical trials in non-candidate transplant patients with newly diagnosed multiple myeloma
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Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
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Discovery of a novel deaminated metabolite of a single-stranded oligonucleotide in vivo by mass spectrometry
Li, Jing, Liu, Ju, Enders, Jennifer, Arciprete, Michael, Tran, Chris, Aluri, Krishna, Guan, Li-Hua, O'Shea, Jonathan, Bisbe, Anna, Charissé, Klaus, Zlatev, Ivan, Najarian, Diana, Xu, Yuanxin
Published in Bioanalysis (01.11.2019)
Published in Bioanalysis (01.11.2019)
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CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS
MAIER, Martin A, BISBE, Anna, KEL'IN, Alexander V, NAIR, Jayaprakash K, PIERSON, Justin M, TANG, Cheng
Year of Publication 08.02.2024
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Year of Publication 08.02.2024
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CYCLIC-DISULFIDE MODIFIED PHOSPHATE BASED OLIGONUCLEOTIDE PRODRUGS
MAIER, Martin A, BISBE, Anna, KEL'IN, Alexander V, NAIR, Jayaprakash K, PIERSON, Justin M, TANG, Cheng
Year of Publication 08.11.2023
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Year of Publication 08.11.2023
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