Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7‑Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists
Vavřina, Zdeněk, Perlíková, Pavla, Milisavljević, Nemanja, Chevrier, Florian, Smola, Miroslav, Smith, Joshua, Dejmek, Milan, Havlíček, Vojtěch, Buděšínský, Miloš, Liboska, Radek, Vaneková, Lenka, Brynda, Jiří, Boura, Evzen, Řezáčová, Pavlína, Hocek, Michal, Birkuš, Gabriel
Published in Journal of medicinal chemistry (27.10.2022)
Published in Journal of medicinal chemistry (27.10.2022)
Get full text
Journal Article
Enzymatic Preparation of 2′–5′,3′–5′-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Novotná, Barbora, Vaneková, Lenka, Zavřel, Martin, Buděšínský, Miloš, Dejmek, Milan, Smola, Miroslav, Gutten, Ondrej, Tehrani, Zahra Aliakbar, Pimková Polidarová, Markéta, Brázdová, Andrea, Liboska, Radek, Štěpánek, Ivan, Vavřina, Zdeněk, Jandušík, Tomáš, Nencka, Radim, Rulíšek, Lubomír, Bouřa, Evžen, Brynda, Jiří, Páv, Ondřej, Birkuš, Gabriel
Published in Journal of medicinal chemistry (12.12.2019)
Published in Journal of medicinal chemistry (12.12.2019)
Get full text
Journal Article
Enzymatic Synthesis of 3′–5′, 3′–5′ Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Novotná, Barbora, Holá, Lucie, Staś, Monika, Gutten, Ondrej, Smola, Miroslav, Zavřel, Martin, Vavřina, Zdeněk, Buděšínský, Miloš, Liboska, Radek, Chevrier, Florian, Dobiaš, Juraj, Boura, Evzen, Rulíšek, Lubomír, Birkuš, Gabriel
Published in Biochemistry (Easton) (07.12.2021)
Published in Biochemistry (Easton) (07.12.2021)
Get full text
Journal Article
Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat
Lepist, Eve-Irene, Zhang, Xuexiang, Hao, Jia, Huang, Jane, Kosaka, Alan, Birkus, Gabriel, Murray, Bernard P., Bannister, Roy, Cihlar, Tomas, Huang, Yong, Ray, Adrian S.
Published in Kidney international (01.08.2014)
Published in Kidney international (01.08.2014)
Get full text
Journal Article
Discovery of isonucleotidic CDNs as potent STING agonists with immunomodulatory potential
Dejmek, Milan, Šála, Michal, Brazdova, Andrea, Vanekova, Lenka, Smola, Miroslav, Klíma, Martin, Břehová, Petra, Buděšínský, Miloš, Dračínský, Martin, Procházková, Eliška, Zavřel, Martin, Šimák, Ondřej, Páv, Ondřej, Boura, Evzen, Birkuš, Gabriel, Nencka, Radim
Published in Structure (London) (04.08.2022)
Published in Structure (London) (04.08.2022)
Get full text
Journal Article
Multiple Classes of Antiviral Agents Exhibit In Vitro Activity against Human Rhinovirus Type C
MELLO, Chris, AGUAYO, Esmeralda, RODRIGUEZ, Madeleine, LEE, Gary, JORDAN, Robert, CIHLAR, Tomas, BIRKUS, Gabriel
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Published in Antimicrobial Agents and Chemotherapy (01.03.2014)
Get full text
Journal Article
Molecular Determinants of GS-9620-Dependent TLR7 Activation
Rebbapragada, Indrani, Birkus, Gabriel, Perry, Jason, Xing, Weimei, Kwon, HyockJoo, Pflanz, Stefan
Published in PloS one (19.01.2016)
Published in PloS one (19.01.2016)
Get full text
Journal Article
Cathepsin A Is the Major Hydrolase Catalyzing the Intracellular Hydrolysis of the Antiretroviral Nucleotide Phosphonoamidate Prodrugs GS-7340 and GS-9131
BIRKUS, Gabriel, WANG, Ruth, XIAOHONG LIU, KUTTY, Nilima, MACARTHUR, Holly, CIHLAR, Tomas, GIBBS, Craig, SWAMINATHAN, Swami, LEE, William, MCDERMOTT, Martin
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Get full text
Journal Article
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Sarah A Gilmore, Danny Tam, Tara L Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M Brendza, Todd C Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H Tay, William E Delaney, Gregory T Notte, Uli Schmitz, Becket Feierbach
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
Get full text
Journal Article
Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus
Gilmore, Sarah A, Tam, Danny, Cheung, Tara L, Snyder, Chelsea, Farand, Julie, Dick, Ryan, Matles, Mike, Feng, Joy Y, Ramirez, Ricardo, Li, Li, Yu, Helen, Xu, Yili, Barnes, Dwight, Czerwieniec, Gregg, Brendza, Katherine M, Appleby, Todd C, Birkus, Gabriel, Willkom, Madeleine, Kobayashi, Tetsuya, Paoli, Eric, Labelle, Marc, Boesen, Thomas, Tay, Chin H, Delaney, 4th, William E, Notte, Gregory T, Schmitz, Uli, Feierbach, Becket
Published in PloS one (07.12.2022)
Published in PloS one (07.12.2022)
Get full text
Journal Article
Multiparametric Flow Cytometry-Based Immunophenotyping of Mouse Liver Immune Cells
Vanekova, Lenka, Polidarova, Marketa Pimkova, Veverka, Vaclav, Birkus, Gabriel, Brazdova, Andrea
Published in Methods and protocols (03.09.2022)
Published in Methods and protocols (03.09.2022)
Get full text
Journal Article
Evaluation of the Effect of Cobicistat on the In Vitro Renal Transport and Cytotoxicity Potential of Tenofovir
STRAY, Kirsten M, BAM, Rujuta A, BIRKUS, Gabriel, JIA HAO, LEPIST, Eve-Irene, YANT, Stephen R, RAY, Adrian S, CIHLAR, Tomas
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Get full text
Journal Article
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Polymerase activity and mechanisms of action of nucleotide analogs
Barauskas, Ona, Xing, Weimei, Aguayo, Esmeralda, Willkom, Madeleine, Sapre, Annapurna, Clarke, Michael, Birkus, Gabriel, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y
Published in PloS one (11.10.2017)
Published in PloS one (11.10.2017)
Get full text
Journal Article
Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and Other Tenofovir Phosphonoamidate Prodrugs by Human Proteases
Birkus, Gabriel, Kutty, Nilima, He, Gong-Xin, Mulato, Andrew, Lee, William, McDermott, Martin, Cihlar, Tomas
Published in Molecular pharmacology (01.07.2008)
Published in Molecular pharmacology (01.07.2008)
Get full text
Journal Article
Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment
Feng, Joy Y, Wang, Ting, Park, Yeojin, Babusis, Darius, Birkus, Gabriel, Xu, Yili, Voitenleitner, Christian, Fenaux, Martijn, Yang, Huiling, Eng, Stacey, Tirunagari, Neeraj, Kirschberg, Thorsten, Cho, Aesop, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Get full text
Journal Article
Biochemical characterization of recombinant influenza A polymerase heterotrimer complex: Endonuclease activity and evaluation of inhibitors
Xing, Weimei, Barauskas, Ona, Kirschberg, Thorsten, Niedziela-Majka, Anita, Clarke, Michael, Birkus, Gabriel, Weissburg, Perry, Liu, Xiaohong, Schultz, Brian E, Sakowicz, Roman, Kwon, HyockJoo, Feng, Joy Y
Published in PloS one (15.08.2017)
Published in PloS one (15.08.2017)
Get full text
Journal Article
Role of Cathepsin A and Lysosomes in the Intracellular Activation of Novel Antipapillomavirus Agent GS-9191
BIRKUS, Gabriel, KUTTY, Nilima, FREY, Christian R, SHRIBATA, Riri, CHOU, Tsuifen, WAGNER, Carston, MCDERMOTT, Martin, CIHLAR, Tomas
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Published in Antimicrobial Agents and Chemotherapy (01.05.2011)
Get full text
Journal Article
GS-9219—A Novel Acyclic Nucleotide Analogue with Potent Antineoplastic Activity in Dogs with Spontaneous Non–Hodgkin's Lymphoma
Reiser, Hans, Wang, Jianying, Chong, Lee, Watkins, William J, Ray, Adrian S, Shibata, Riri, Birkus, Gabriel, Cihlar, Tomas, Wu, Sylvia, Li, Bei, Liu, Xiaohong, Henne, Ilana N, Wolfgang, Grushenka H I, Desai, Manoj, Rhodes, Gerald R, Fridland, Arnold, Lee, William A, Plunkett, William, Vail, David, Thamm, Douglas H, Jeraj, Robert, Tumas, Daniel B
Published in Clinical cancer research (01.05.2008)
Published in Clinical cancer research (01.05.2008)
Get full text
Journal Article
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148
Mackman, Richard L., Ray, Adrian S., Hui, Hon C., Zhang, Lijun, Birkus, Gabriel, Boojamra, Constantine G., Desai, Manoj C., Douglas, Janet L., Gao, Ying, Grant, Deborah, Laflamme, Genevieve, Lin, Kuei-Ying, Markevitch, David Y., Mishra, Ruchika, McDermott, Martin, Pakdaman, Rowchanak, Petrakovsky, Oleg V., Vela, Jennifer E., Cihlar, Tomas
Published in Bioorganic & medicinal chemistry (15.05.2010)
Published in Bioorganic & medicinal chemistry (15.05.2010)
Get full text
Journal Article