Iodoetherification as a strategy towards sp3-rich scaffolds for drug discovery
Barnes, Lydia, Birkinshaw, Timothy N., Senior, Aaron J., Brügge, Oscar Siles, Lewis, William, Argent, Stephen P., Moody, Christopher J., Nortcliffe, Andrew
Published in Bioorganic & medicinal chemistry (01.03.2024)
Published in Bioorganic & medicinal chemistry (01.03.2024)
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From ATP to AZD6140 : The discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis
SPRINGTHORPE, Brian, BAILEY, Andrew, HUNT, Simon F, INCE, Francis, INGALL, Anthony H, KIRK, Ian P, LEESON, Paul D, LEFF, Paul, LEWIS, Richard J, MARTIN, Barrie P, MCGINNITY, Dermot F, MORTIMORE, Michael P, BARTON, Patrick, PAINE, Stuart W, PAIRAUDEAU, Garry, PATEL, Anil, RIGBY, Aaron J, RILEY, Robert J, TEOBALD, Barry J, TOMLINSON, Wendy, WEBBORN, Peter J. H, WILLIS, Paul A, BIRKINSHAW, Timothy N, BONNERT, Roger V, BROWN, Roger C, CHAPMAN, David, DIXON, John, GUILE, Simon D, HUMPHRIES, Robert G
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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In silico prediction of acyl glucuronide reactivity
Potter, Tim, Lewis, Richard, Luker, Tim, Bonnert, Roger, Bernstein, Michael A., Birkinshaw, Timothy N., Thom, Stephen, Wenlock, Mark, Paine, Stuart
Published in Journal of computer-aided molecular design (01.11.2011)
Published in Journal of computer-aided molecular design (01.11.2011)
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The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS)
Cheshire, David R., Åberg, Anders, Andersson, Gunilla M.K., Andrews, Glen, Beaton, Haydn G., Birkinshaw, Timothy N., Boughton-Smith, Nigel, Connolly, Stephen, Cook, Tony R., Cooper, Anne, Cooper, Sally L., Cox, David, Dixon, John, Gensmantel, Nigel, Hamley, Peter J., Harrison, Richard, Hartopp, Paul, Käck, Helena, Leeson, Paul D., Luker, Timothy, Mete, Antonio, Millichip, Ian, Nicholls, David J., Pimm, Austen D., St-Gallay, Steve A., Wallace, Alan V.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Discovery of potent CRTh2 (DP 2) receptor antagonists
Birkinshaw, Timothy N., Teague, Simon J., Beech, Claire, Bonnert, Roger V., Hill, Stephen, Patel, Anil, Reakes, Sara, Sanganee, Hitesh, Dougall, Iain G., Phillips, Tim T., Salter, Sylvia, Schmidt, Jerzy, Arrowsmith, Elizabeth C., Carrillo, Juan J., Bell, Fiona M., Paine, Stuart W., Weaver, Richard
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
Published in Bioorganic & medicinal chemistry letters (15.08.2006)
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Journal Article
Iodoetherification as a strategy towards sp 3 -rich scaffolds for drug discovery
Barnes, Lydia, Birkinshaw, Timothy N, Senior, Aaron J, Brügge, Oscar Siles, Lewis, William, Argent, Stephen P, Moody, Christopher J, Nortcliffe, Andrew
Published in Bioorganic & medicinal chemistry (01.03.2024)
Get full text
Published in Bioorganic & medicinal chemistry (01.03.2024)
Journal Article
From ATP to AZD6140: The discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis
Springthorpe, Brian, Bailey, Andrew, Barton, Patrick, Birkinshaw, Timothy N., Bonnert, Roger V., Brown, Roger C., Chapman, David, Dixon, John, Guile, Simon D., Humphries, Robert G., Hunt, Simon F., Ince, Francis, Ingall, Anthony H., Kirk, Ian P., Leeson, Paul D., Leff, Paul, Lewis, Richard J., Martin, Barrie P., McGinnity, Dermot F., Mortimore, Michael P., Paine, Stuart W., Pairaudeau, Garry, Patel, Anil, Rigby, Aaron J., Riley, Robert J., Teobald, Barry J., Tomlinson, Wendy, Webborn, Peter J.H., Willis, Paul A.
Published in Bioorganic & medicinal chemistry letters (2007)
Published in Bioorganic & medicinal chemistry letters (2007)
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2-(N,N-disubstituted amino)thiazoles with electron-withdrawing groups at position 5: preparation and investigation of structural features
BIRKINSHAW, T. N, GILLON, D. W, HARKIN, S. A, MEAKINS, G. D, TIREL, M. D
Published in Journal of the Chemical Society, Perkin Transactions 1 (1984)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1984)
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Imino Diels-Alder reaction of 2-t-butyldimethylsilyloxycyclohexadiene: isolation of an azabicyclo[2.2.2]octene silyl enol ether adduct
BIRKINSHAW, T. N, TABOR, A. B, HOLMES, A. B, RAITHBY, P. R
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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The products of an imino Diels-Alder reaction with 2-trimethylsilyloxycyclohexadiene: synthesis, X-ray crystal structures, and mechanistic implications
BIRKINSHAW, T. N, TABOR, A. B, HOLMES, A. B, KAYE, P, MAYNE, P. M, RAITHBY, P. R
Published in Journal of the Chemical Society. Chemical communications (1988)
Published in Journal of the Chemical Society. Chemical communications (1988)
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