Anti- Aspergillus activities of olorofim at sub-MIC levels during early-stage growth
Kühbacher, Alexander, Birch, Mike, Oliver, Jason D, Gsaller, Fabio
Published in Microbiology spectrum (05.03.2024)
Published in Microbiology spectrum (05.03.2024)
Get full text
Journal Article
Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance
Buil, Jochem B., Oliver, Jason D., Law, Derek, Baltussen, Tim, Zoll, Jan, Hokken, Margriet W. J., Tehupeiory-Kooreman, Marlou, Melchers, Willem J. G., Birch, Mike, Verweij, Paul E.
Published in Emerging microbes & infections (31.12.2022)
Published in Emerging microbes & infections (31.12.2022)
Get full text
Journal Article
In Vitro Activity of Novel Antifungal Olorofim against Filamentous Fungi and Comparison to Eight Other Antifungal Agents
Georgacopoulos, Ourania, Nunnally, Natalie, Ransom, Eric, Law, Derek, Birch, Mike, Lockhart, Shawn, Berkow, Elizabeth
Published in Journal of fungi (Basel) (12.05.2021)
Published in Journal of fungi (Basel) (12.05.2021)
Get full text
Journal Article
The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus
du Pré, Saskia, Birch, Mike, Law, Derek, Beckmann, Nicola, Sibley, Graham E M, Bromley, Michael J, Read, Nick D, Oliver, Jason D
Published in Journal of fungi (Basel) (10.04.2020)
Published in Journal of fungi (Basel) (10.04.2020)
Get full text
Journal Article
The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence
Oliver, Jason D, Kaye, Sarah J, Tuckwell, Danny, Johns, Anna E, Macdonald, Darel A, Livermore, Joanne, Warn, Peter A, Birch, Mike, Bromley, Michael J
Published in PloS one (18.09.2012)
Published in PloS one (18.09.2012)
Get full text
Journal Article
The Transposon impala Is Activated by Low Temperatures: Use of a Controlled Transposition System To Identify Genes Critical for Viability of Aspergillus fumigatus
Carr, Paul D, Tuckwell, Danny, Hey, Peter M, Simon, Laurence, d'Enfert, Christophe, Birch, Mike, Oliver, Jason D, Bromley, Michael J
Published in Eukaryotic Cell (01.03.2010)
Published in Eukaryotic Cell (01.03.2010)
Get full text
Journal Article
F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase
Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (08.11.2016)
Get full text
Journal Article
Madurella mycetomatis, the main causative agent of eumycetoma, is highly susceptible to olorofim
Lim, Wilson, Eadie, Kimberly, Konings, Mickey, Rijnders, Bart, Fahal, Ahmed H, Oliver, Jason D, Birch, Mike, Verbon, Annelies, van de Sande, Wendy
Published in Journal of antimicrobial chemotherapy (01.04.2020)
Published in Journal of antimicrobial chemotherapy (01.04.2020)
Get full text
Journal Article
Characterisation of putative class 1A DHODH-like proteins from Mucorales and dematiaceous mould species
Pinder, Corinne, Lebedinec, Ressa, Levine, Tim P, Birch, Mike, Oliver, Jason D
Published in PloS one (02.08.2023)
Published in PloS one (02.08.2023)
Get full text
Journal Article
Dihydroorotate dehydrogenase inhibitor olorofim exhibits promising activity against all clinically relevant species within Aspergillus section Terrei
Lackner, Michaela, Birch, Mike, Naschberger, Verena, Grässle, Denise, Beckmann, Nicola, Warn, Peter, Gould, Julie, Law, Derek, Lass-Flörl, Cornelia, Binder, Ulrike
Published in Journal of antimicrobial chemotherapy (01.11.2018)
Published in Journal of antimicrobial chemotherapy (01.11.2018)
Get full text
Journal Article
In vitro activity of olorofim against 507 filamentous fungi including antifungal drug-resistant strains at a tertiary laboratory in Australia: 2020–2023
Halliday, Catriona L, Tay, Enoch, Green, Wendy, Law, Derek, Lopez, Ronald, Faris, Silvia, Meehan, Lauren, Harvey, Emma, Birch, Mike, Chen, Sharon C A
Published in Journal of antimicrobial chemotherapy (01.10.2024)
Published in Journal of antimicrobial chemotherapy (01.10.2024)
Get full text
Journal Article
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus
du Pré, Saskia, Beckmann, Nicola, Almeida, Mariana Cruz, Sibley, Graham E M, Law, Derek, Brand, Alexandra C, Birch, Mike, Read, Nick D, Oliver, Jason D
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Published in Antimicrobial agents and chemotherapy (01.08.2018)
Get full text
Journal Article
Aspergillus fumigatus strains that evolve resistance to the agrochemical fungicide ipflufenoquin in vitro are also resistant to olorofim
van Rhijn, Norman, Storer, Isabelle S. R., Birch, Mike, Oliver, Jason D., Bottery, Michael J., Bromley, Michael J.
Published in Nature microbiology (01.01.2024)
Published in Nature microbiology (01.01.2024)
Get full text
Journal Article
A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity
Johns, Anna, Scharf, Daniel H, Gsaller, Fabio, Schmidt, Hella, Heinekamp, Thorsten, Straßburger, Maria, Oliver, Jason D, Birch, Mike, Beckmann, Nicola, Dobb, Katharine S, Gilsenan, Jane, Rash, Bharatkumar, Bignell, Elaine, Brakhage, Axel A, Bromley, Michael J
Published in mBio (18.07.2017)
Published in mBio (18.07.2017)
Get full text
Journal Article
The Three-Dimensional Structure of the Connective Tissue in the Lamina Cribrosa of the Human Optic Nerve Head
Birch, Mike, Brotchie, Daniel, Roberts, Neil, Grierson, Ian
Published in Ophthalmologica (Basel) (01.01.1997)
Published in Ophthalmologica (Basel) (01.01.1997)
Get full text
Journal Article
Conference Proceeding