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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

by Khare, Shilpi, Nagle, Advait S., Biggart, Agnes, Lai, Yin H., Liang, Fang, Davis, Lauren C., Barnes, S. Whitney, Mathison, Casey J. N., Myburgh, Elmarie, Gao, Mu-Yun, Gillespie, J. Robert, Liu, Xianzhong, Tan, Jocelyn L., Stinson, Monique, Rivera, Ianne C., Ballard, Jaime, Yeh, Vince, Groessl, Todd, Federe, Glenn, Koh, Hazel X. Y., Venable, John D., Bursulaya, Badry, Shapiro, Michael, Mishra, Pranab K., Spraggon, Glen, Brock, Ansgar, Mottram, Jeremy C., Buckner, Frederick S., Rao, Srinivasa P. S., Wen, Ben G., Walker, John R., Tuntland, Tove, Molteni, Valentina, Glynne, Richard J., Supek, Frantisek
Published in Nature (London) (08.09.2016)

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Journal Article

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases

by Nagle, Advait, Biggart, Agnes, Be, Celine, Srinivas, Honnappa, Hein, Andreas, Caridha, Diana, Sciotti, Richard J, Pybus, Brandon, Kreishman-Deitrick, Mara, Bursulaya, Badry, Lai, Yin H, Gao, Mu-Yun, Liang, Fang, Mathison, Casey J. N, Liu, Xiaodong, Yeh, Vince, Smith, Jeffrey, Lerario, Isabelle, Xie, Yongping, Chianelli, Donatella, Gibney, Michael, Berman, Ashley, Chen, Yen-Liang, Jiricek, Jan, Davis, Lauren C, Liu, Xianzhong, Ballard, Jaime, Khare, Shilpi, Eggimann, Fabian Kurt, Luneau, Alexandre, Groessl, Todd, Shapiro, Michael, Richmond, Wendy, Johnson, Kevin, Rudewicz, Patrick J, Rao, Srinivasa P. S, Thompson, Christopher, Tuntland, Tove, Spraggon, Glen, Glynne, Richard J, Supek, Frantisek, Wiesmann, Christian, Molteni, Valentina
Published in Journal of medicinal chemistry (08.10.2020)

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Journal Article

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by LIANG FANG, MATHISON CASEY JACOB NELSON, NAGLE ADVAIT SURESH, BIGGART AGNES, YEH VINCE, MOLTENI VALENTINA, SUPEK FRANTISEK
Year of Publication 05.08.2016

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Patent

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 02.12.2021

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by MATHISON, CASEY JACOB NELSON, LIANG, FANG, NAGLE, ADVAIT SURESH, SUPEK, FRANTISEK, BIGGART, AGNES, YEH, VINCE, MOLTENI, VALENTINA
Year of Publication 09.11.2021

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Patent

Compounds and compositions for the treatment of parasitic diseases

Compounds and compositions for the treatment of parasitic diseases

by Molteni, Valentina, Nagle, Advait Suresh, Biggart, Agnes, Mathison, Casey Jacob Nelson, Supek, Frantisek, Liang, Fang, Yeh, Vince
Year of Publication 21.09.2021

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 14.07.2020

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Patent

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 11.06.2020

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Patent

Compounds and compositions for the treatment of parasitic diseases

Compounds and compositions for the treatment of parasitic diseases

by Molteni, Valentina, Nagle, Advait Suresh, Biggart, Agnes, Mathison, Casey Jacob Nelson, Supek, Frantisek, Liang, Fang, Yeh, Vince
Year of Publication 24.03.2020

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by LIANG, FANG, MATHISON, CASEY, JACOB, NELSON, NAGLE, ADVAIT, SURESH, SUPEK, FRANTISEK, BIGGART, AGNES, YEH, VINCE, MOLTENI, VALENTINA
Year of Publication 28.02.2019

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by MATHISON, CASEY JACOB NELSON, LIANG, FANG, NAGLE, ADVAIT SURESH, SUPEK, FRANTISEK, BIGGART, AGNES, YEH, VINCE, MOLTENI, VALENTINA
Year of Publication 28.02.2019

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 28.02.2019

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Patent

(1,2,4)TRIAZOLO(1,5-A)PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

(1,2,4)TRIAZOLO(1,5-A)PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by YEH Vince, LIANG Fang, NAGLE Advait Suresh, BIGGART Agnes, MOLTENI Valentina, SUPEK Frantisek, MATHISON Casey Jacob Nelson
Year of Publication 31.01.2019

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by Molteni, Valentina, Nagle, Advait Suresh, Biggart, Agnes, Mathison, Casey Jacob Nelson, Supek, Frantisek, Liang, Fang, Yeh, Vince
Year of Publication 25.01.2019

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Patent

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 03.01.2019

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Patent

[1,2,4]TRIAZOL[1,5-A]PYRIMIDINDERIVATER SOM PROTOZOISKE PROTEASOMINHIBITORER TIL BEHANDLING AF PARASITSYGDOMME, SÅSOM LEISHMANIASIS

[1,2,4]TRIAZOL[1,5-A]PYRIMIDINDERIVATER SOM PROTOZOISKE PROTEASOMINHIBITORER TIL BEHANDLING AF PARASITSYGDOMME, SÅSOM LEISHMANIASIS

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 02.01.2019

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by BIGGART, Agnes, NAGLE, Advait Suresh, MATHISON, Casey Jacob Nelson, YEH, Vince, LIANG, Fang, MOLTENI, Valentina, SUPEK, Frantisek
Year of Publication 27.12.2018

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Patent

[1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis

[1,2,4]triazolo[1,5-a]pyrimidine derivatives as protozoan proteasome inhibitors for the treatment of parasitic diseases such as leishmaniasis

by Molteni, Valentina, Nagle, Advait Suresh, Biggart, Agnes, Mathison, Casey Jacob Nelson, Supek, Frantisek, Liang, Fang, Yeh, Vince
Year of Publication 21.12.2018

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Patent

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE DERIVATIVES AS PROTOZOAN PROTEASOME INHIBITORS FOR THE TREATMENT OF PARASITIC DISEASES SUCH AS LEISHMANIASIS

by ADVAIT SURESH NAGLE, CASEY JACOB NELSON MATHISON, FANG LIANG, AGNES BIGGART, VALENTINA MOLTENI, FRANTISEK SUPEK, VINCE YEH
Year of Publication 30.11.2018

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Patent

Compounds and compositions for the treatment of parasitic diseases

Compounds and compositions for the treatment of parasitic diseases

by Molteni, Valentina, Nagle, Advait Suresh, Biggart, Agnes, Mathison, Casey Jacob Nelson, Supek, Frantisek, Liang, Fang, Yeh, Vince
Year of Publication 02.10.2018

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Patent