Search Results - "BHYRAPUNENI GOPINADH" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation

Samelisant (SUVN-G3031), a potent, selective and orally active histamine H3 receptor inverse agonist for the potential treatment of narcolepsy: pharmacological and neurochemical characterisation

by Nirogi, Ramakrishna, Benade, Vijay, Daripelli, Saivishal, Subramanian, Ramkumar, Kamuju, Venkatesh, Bhyrapuneni, Gopinadh, Muddana, Nageswara Rao, Mekala, Venkat Reddy, Petlu, Surendra, Jayarajan, Pradeep, Badange, Rajesh, Shinde, Anil, Jasti, Venkat
Published in Psychopharmacology (01.06.2021)

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Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders

Histamine 3 receptor inverse agonist Samelisant (SUVN-G3031): Pharmacological characterization of an investigational agent for the treatment of cognitive disorders

by Nirogi, Ramakrishna, Grandhi, Venkata R, Medapati, Rajesh B, Ganuga, Narender, Benade, Vijay, Gandipudi, Sudhakar, Manoharan, Arunkumar, Abraham, Renny, Jayarajan, Pradeep, Bhyrapuneni, Gopinadh, Shinde, Anil, Badange, Rajesh K, Subramanian, Ramkumar, Petlu, Surendra, Jasti, Venkat
Published in Journal of psychopharmacology (Oxford) (01.06.2021)

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Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro – in vivo extrapolation of hepatic clearance

by Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Ponnamaneni, Ranjith Kumar, Padala, Nagasurya Prakash, Boggavarapu, Rajesh Kumar, Bhyrapuneni, Gopinadh, Ajjala, Devender Reddy, Nirogi, Ramakrishna
Published in European journal of pharmaceutical sciences (01.04.2017)

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$Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays$

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays

by Nirogi, Ramakrishna, Palacharla, Raghava Choudary, Uthukam, Venkatesham, Manoharan, Arunkumar, Srikakolapu, Surya Rao, Kalaikadhiban, Ilayaraja, Boggavarapu, Rajesh Kumar, Ponnamaneni, Ranjith Kumar, Ajjala, Devender Reddy, Bhyrapuneni, Gopinadh
Published in Xenobiotica (01.02.2015)

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Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions

by Nirogi, Ramakrishna, Kandikere, Vishwottam, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Kanamarlapudi, Vijaya Bhargava, Ponnamaneni, Ranjith Kumar, Manoharan, Arun Kumar
Published in Xenobiotica (01.03.2014)

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Rat thalamic α4β2 neuronal nicotinic acetylcholine receptor occupancy assay using LC–MS/MS

Rat thalamic α4β2 neuronal nicotinic acetylcholine receptor occupancy assay using LC–MS/MS

by Nirogi, Ramakrishna, Kandikere, Vishwottam, Bhyrapuneni, Gopinadh, Saralaya, Ramanatha, Muddana, Nageswararao, Ajjala, Devender Reddy
Published in Journal of pharmacological and toxicological methods (01.05.2012)

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Evaluation of monoamine oxidase A and B type enzyme occupancy using non-radiolabelled tracers in rat brain

Evaluation of monoamine oxidase A and B type enzyme occupancy using non-radiolabelled tracers in rat brain

by Thentu, Jagadeesh Babu, Bhyrapuneni, Gopinadh, Padala, Nagasurya Prakash, Chunduru, Prathyusha, Pantangi, Hanumanth Rao, Nirogi, Ramakrishna
Published in Neurochemistry international (01.05.2021)

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506 Samelisant: Baseline Characteristics from a Phase 2 Study Evaluating Efficacy and Safety in Patients with Narcolepsy

506 Samelisant: Baseline Characteristics from a Phase 2 Study Evaluating Efficacy and Safety in Patients with Narcolepsy

by Nirogi, Ramakrishna, Ravula, Jyothsna, Jayarajan, Pradeep, Jetta, Satish, Bhyrapuneni, Gopinadh, Benade, Vijay, Shinde, Anil, Goyal, Vinod
Published in Sleep (New York, N.Y.) (03.05.2021)

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Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine alpha 4 beta 2 Receptor Antagonist for the Treatment of Depression

Discovery and Development of 3-(6-Chloropyridine-3-yloxymethyl)-2-azabicyclo[3.1.0]hexane Hydrochloride (SUVN-911): A Novel, Potent, Selective, and Orally Active Neuronal Nicotinic Acetylcholine alpha 4 beta 2 Receptor Antagonist for the Treatment of Depression

by Nirogi, Ramakrishna, Mohammed, Abdul Rasheed, Shinde, Anil K., Ravella, Srinivasa Rao, Bogaraju, Narsimha, Subramanian, Ramkumar, Mekala, Venkat Reddy, Palacharla, Raghava Choudary, Muddana, Nageswararao, Thentu, Jagadeesh Babu, Bhyrapuneni, Gopinadh, Abraham, Renny, Jasti, Venkat
Published in Journal of medicinal chemistry (26.03.2020)

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$The use of inactivated brain homogenate to determine the in vitro fraction unbound in brain for unstable compounds$

The use of inactivated brain homogenate to determine the in vitro fraction unbound in brain for unstable compounds

by Nirogi, Ramakrishna, Molgara, Parusharamulu, Bhyrapuneni, Gopinadh, Manoharan, Arunkumar, Padala, Nagasurya Prakash, Palacharla, Veera Raghava Chowdary
Published in Xenobiotica (02.10.2020)

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A simple and rapid method to collect the cerebrospinal fluid of rats and its application for the assessment of drug penetration into the central nervous system

A simple and rapid method to collect the cerebrospinal fluid of rats and its application for the assessment of drug penetration into the central nervous system

by Nirogi, Ramakrishna, Kandikere, Vishwottam, Mudigonda, Koteshwara, Bhyrapuneni, Gopinadh, Muddana, Nageswararao, Saralaya, Ramanatha, Benade, Vijay
Published in Journal of neuroscience methods (30.03.2009)

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Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)

Development and Validation of a Higher-Throughput Cytochrome P450 Inhibition Assay with the Novel Cofactor-Supplemented Permeabilized Cryopreserved Human Hepatocytes (MetMax Human Hepatocytes)

by Palacharla, Veera Raghava Choudary, Chunduru, Prathyusha, Ajjala, Devender Reddy, Bhyrapuneni, Gopinadh, Nirogi, Ramakrishna, Li, Albert P
Published in Drug metabolism and disposition (01.10.2019)

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A sensitive and selective quantification of catecholamine neurotransmitters in rat microdialysates by pre-column dansyl chloride derivatization using liquid chromatography–tandem mass spectrometry

A sensitive and selective quantification of catecholamine neurotransmitters in rat microdialysates by pre-column dansyl chloride derivatization using liquid chromatography–tandem mass spectrometry

by Nirogi, Ramakrishna, Komarneni, Prashanth, Kandikere, Vishwottam, Boggavarapu, Rajeshkumar, Bhyrapuneni, Gopinadh, Benade, Vijay, Gorentla, Srinivasarao
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.01.2013)

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Discovery and Development of 1-[(2-Bromophenyl)sulfony1]-5methoxy-3-[(4-methyl-1-piperazinyl)methy1]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease

Discovery and Development of 1-[(2-Bromophenyl)sulfony1]-5methoxy-3-[(4-methyl-1-piperazinyl)methy1]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease

by Nirogi, Ramakrishna, Shinde, Anil, Kambhampati, Rama Sastry, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Mohammed, Abdul Rasheed, Saraf, Sangram Keshari, Badange, Rajesh Kumar, Bandyala, Thrinath Reddy, Bhatta, Venugopalarao, Bojja, Kumar, Reballi, Veena, Subramanian, Ramkumar, Benade, Vijay, Palacharla, Raghava Choudary, Bhyrapuneni, Gopinadh, Jayarajan, Pradeep, Goyal, Vinod, Jasti, Venkat
Published in Journal of medicinal chemistry (09.03.2017)

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0139 SUVN-G3031, A Potent and Selective Histamine H3 Receptor Inverse Agonist - Phase-2 Investigational New Drug for the Treatment of Narcolepsy - Differentiating Factors with Competitor Clinical Candidates

0139 SUVN-G3031, A Potent and Selective Histamine H3 Receptor Inverse Agonist - Phase-2 Investigational New Drug for the Treatment of Narcolepsy - Differentiating Factors with Competitor Clinical Candidates

by Nirogi, Ramakrishna, Bhyrapuneni, Gopinadh, Abraham, Renny, Subramanian, Ramkumar, Goyal, Vinod Kumar, Pandey, Santosh Kumar, Badange, Rajesh, Shinde, Anil
Published in Sleep (New York, N.Y.) (13.04.2019)

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Masupirdine in combination with donepezil and memantine in patients with moderate Alzheimer's disease: Subgroup analyses of memantine regimen, plasma concentrations and duration of treatment: Human/Human trials: Other

Masupirdine in combination with donepezil and memantine in patients with moderate Alzheimer's disease: Subgroup analyses of memantine regimen, plasma concentrations and duration of treatment: Human/Human trials: Other

by Nirogi, Ramakrishna, Goyal, Vinod Kumar, Bhyrapuneni, Gopinadh, Palacharla, Veera Raghava Chowdary, Ravulu, Jyothsna, Jetta, Satish, Jasti, Venkat
Published in Alzheimer's & dementia (01.12.2020)

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Masupirdine in combination with donepezil and memantine in patients with moderate Alzheimer's disease: Subgroup analyses of memantine regimen, plasma concentrations and duration of treatment

Masupirdine in combination with donepezil and memantine in patients with moderate Alzheimer's disease: Subgroup analyses of memantine regimen, plasma concentrations and duration of treatment

by Nirogi, Ramakrishna, Goyal, Vinod Kumar, Bhyrapuneni, Gopinadh, Palacharla, Veera Raghava Chowdary, Ravulu, Jyothsna, Jetta, Satish, Jasti, Venkat
Published in Alzheimer's & dementia (01.12.2020)

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SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization

SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization

by Nirogi, Ramakrishna, Abraham, Renny, Benade, Vijay, Medapati, Rajesh B, Jayarajan, Pradeep, Bhyrapuneni, Gopinadh, Muddana, NageswaraRao, Mekala, Venkat R, Subramanian, Ramkumar, Shinde, Anil, Kambhampati, Ramasastry, Jasti, Venkat
Published in Behavioural pharmacology (01.02.2019)

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Masupirdine (SUVN‐502): A promising clinical candidate for the management of agitation in Alzheimer’s dementia

Masupirdine (SUVN‐502): A promising clinical candidate for the management of agitation in Alzheimer’s dementia

by Nirogi, Ramakrishna, Jayarajan, Pradeep, Tadiparthi, Jayaprakash, Shinde, Anil K, Rasheed, Mohammed Abdul, Goyal, Vinod Kumar, Bhyrapuneni, Gopinadh, Benade, Vijay, Palacharla, Veera Raghava Chowdary, Ravula, Jyothsna, Jetta, Satish
Published in Alzheimer's & dementia (01.12.2021)

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SUVN‐D4010: A serotonin‐4 receptor partial agonist for the treatment of cognitive disorders

SUVN‐D4010: A serotonin‐4 receptor partial agonist for the treatment of cognitive disorders

by Medapati, Rajesh Babu, Ganuga, Narender, Mekala, Venkat Reddy, Bhyrapuneni, Gopinadh, Thentu, Jagadeesh Babu, Daripelli, Saivishal, Gagginapalli, Shankar Reddy, Bogaraju, Narsimha, Rasheed, Mohammed Abdul, Nirogi, Ramakrishna
Published in Alzheimer's & dementia (01.12.2021)

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