Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists
XUEQING WANG, BHATIA, Pramila A, MILLER, Loan N, RENJIE CHANG, MORELAND, Robert B, BRIONI, Jorge D, STEWART, Andrew O, DAANEN, Jerome F, LATSAW, Steve P, ROHDE, Jeffrey, KOLASA, Teodozyi, HAKEEM, Ahmed A, MATULENKO, Mark A, NAKANE, Masaki, UCHIC, Marie E
Published in Bioorganic & medicinal chemistry (01.08.2005)
Published in Bioorganic & medicinal chemistry (01.08.2005)
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Dopamine D4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning
Stewart, Andrew O, Cowart, Marlon D, Moreland, Robert B, Latshaw, Steve P, Matulenko, Mark A, Bhatia, Pramila A, Wang, Xueqing, Daanen, Jerome F, Nelson, Sherry L, Terranova, Marc A, Namovic, Marian T, Donnelly-Roberts, Diana L, Miller, Loan N, Nakane, Masaki, Sullivan, James P, Brioni, Jorge D
Published in Journal of medicinal chemistry (22.04.2004)
Published in Journal of medicinal chemistry (22.04.2004)
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5-Lipoxygenase Inhibitors: Synthesis and Structure−Activity Relationships of a Series of 1-Aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones
Bhatia, Pramila A, Brooks, Clint D. W, Basha, Anwer, Ratajczyk, James D, Gunn, Bruce P, Bouska, Jennifer B, Lanni, Carmine, Young, Patrick R, Bell, Randy L, Carter, George W
Published in Journal of medicinal chemistry (27.09.1996)
Published in Journal of medicinal chemistry (27.09.1996)
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Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets
Zhang, Di, Saraf, Anita, Kolasa, Teodozyi, Bhatia, Pramila, Zheng, Guo Zhu, Patel, Meena, Lannoye, Greg S., Richardson, Paul, Stewart, Andrew, Rogers, John C., Brioni, Jorge D., Surowy, Carol S.
Published in Neuropharmacology (01.03.2007)
Published in Neuropharmacology (01.03.2007)
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Synthesis and Structure−Activity Studies on N-[5-(1H-Imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an Imidazole-Containing α1A-Adrenoceptor Agonist
Altenbach, Robert J, Khilevich, Albert, Kolasa, Teodozyj, Rohde, Jeffrey J, Bhatia, Pramila A, Patel, Meena V, Searle, Xenia B, Yang, Fan, Bunnelle, William H, Tietje, Karin, Bayburt, Erol K, Carroll, William A, Meyer, Michael D, Henry, Rodger, Buckner, Steven A, Kuk, Jane, Daza, Anthony V, Milicic, Ivan V, Cain, John C, Kang, Chae H, Ireland, Lynne M, Carr, Tracy L, Miller, Thomas R, Hancock, Arthur A, Nakane, Masaki, Esbenshade, Timothy A, Brune, Michael E, O'Neill, Alyssa B, Gauvin, Donna M, Katwala, Sweta P, Holladay, Mark W, Brioni, Jorge D, Sullivan, James P
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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A-1048400 is a novel, orally active, state-dependent neuronal calcium channel blocker that produces dose-dependent antinociception without altering hemodynamic function in rats
Scott, Victoria E., Vortherms, Timothy A., Niforatos, Wende, Swensen, Andrew M., Neelands, Torben, Milicic, Ivan, Banfor, Patricia N., King, Andrew, Zhong, Chengmin, Simler, Gricelda, Zhan, Cenchen, Bratcher, Natalie, Boyce-Rustay, Janel M., Zhu, Chang Z., Bhatia, Pramila, Doherty, George, Mack, Helmut, Stewart, Andrew O., Jarvis, Michael F.
Published in Biochemical pharmacology (01.02.2012)
Published in Biochemical pharmacology (01.02.2012)
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Discovery of diphenyl lactam derivatives as N-type calcium channel blockers
Doherty, George A., Bhatia, Pramila, Vortherms, Timothy A., Marsh, Kennan C., Wetter, Jill M., Mack, Helmut, Scott, Victoria E., Jarvis, Michael F., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
Published in Bioorganic & medicinal chemistry letters (15.02.2012)
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Structure−Activity Relationship of Triazafluorenone Derivatives as Potent and Selective mGluR1 Antagonists
Zheng, Guo Zhu, Bhatia, Pramila, Daanen, Jerome, Kolasa, Teodozyj, Patel, Meena, Latshaw, Steven, El Kouhen, Odile F, Chang, Renjie, Uchic, Marie E, Miller, Loan, Nakane, Masaki, Lehto, Sonya G, Honore, Marie P, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (17.11.2005)
Published in Journal of medicinal chemistry (17.11.2005)
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DIAZEPINE DERIVATIVES USEFUL AS CALCIUM CHANNEL BLOCKERS IN THE TREATMENT OF PAIN
SCHRIMPF MICHAEL R, ZHANG QUINWEI I, BHATIA PRAMILA A, RANDOLPH JOHN T
Year of Publication 17.08.2015
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Year of Publication 17.08.2015
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Dopamine D 4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
Bitner, Robert S., Nikkel, Arthur L., Otte, Stephani, Martino, Brenda, Barlow, Eve H., Bhatia, Pramila, Stewart, Andrew O., Brioni, Jorge D., Decker, Michael W., Moreland, Robert B.
Published in Neuropharmacology (01.04.2006)
Published in Neuropharmacology (01.04.2006)
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Journal Article
Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
Bitner, Robert S, Nikkel, Arthur L, Otte, Stephani, Martino, Brenda, Barlow, Eve H, Bhatia, Pramila, Stewart, Andrew O, Brioni, Jorge D, Decker, Michael W, Moreland, Robert B
Published in Neuropharmacology (01.04.2006)
Published in Neuropharmacology (01.04.2006)
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Journal Article
Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction
Cowart, Marlon, Latshaw, Steven P, Bhatia, Pramila, Daanen, Jerome F, Rohde, Jeffrey, Nelson, Sherry L, Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E, Miller, Loan N, Terranova, Marc A, Chang, Renjie, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda R, Lynch, James J, Sullivan, James P, Hsieh, Gin C, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (15.07.2004)
Published in Journal of medicinal chemistry (15.07.2004)
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Journal Article
1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D-4 receptor agonists for the treatment of erectile dysfunction
Kolasa, Teodozyj, Matulenko, Mark A., Hakeem, Ahmed A., Patel, Meena V., Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C., Terranova, Marc A., Uchic, Marie E., Miller, Loan N., Chang, Renje, Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C., Wetter, Jill M., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Journal Article
Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D 4 receptor agonists
Wang, Xueqing, Bhatia, Pramila A., Daanen, Jerome F., Latsaw, Steve P., Rohde, Jeffrey, Kolasa, Teodozyi, Hakeem, Ahmed A., Matulenko, Mark A., Nakane, Masaki, Uchic, Marie E., Miller, Loan N., Chang, Renjie, Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry (01.08.2005)
Published in Bioorganic & medicinal chemistry (01.08.2005)
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Journal Article
Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists
Zheng, Guo Zhu, Bhatia, Pramila, Kolasa, Teodozyj, Patel, Meena, El Kouhen, Odile F., Chang, Renjie, Uchic, Marie E., Miller, Loan, Baker, Scott, Lehto, Sonya G., Honore, Prisca, Wetter, Jill M., Marsh, Kennan C., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
Published in Bioorganic & medicinal chemistry letters (15.09.2006)
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Journal Article
1-Aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one Oximes as Potent Dopamine D4 Receptor Agonists for the Treatment of Erectile Dysfunction
Kolasa, Teodozyj, Matulenko, Mark A, Hakeem, Ahmed A, Patel, Meena V, Mortell, Kathleen, Bhatia, Pramila, Henry, Rodger, Nakane, Masaki, Hsieh, Gin C, Terranova, Marc A, Uchic, Marie E, Miller, Loan N, Chang, Renje, Donnelly-Roberts, Diana L, Namovic, Marian T, Hollingsworth, Peter R, Martino, Brenda, El Kouhen, Odile, Marsh, Kennan C, Wetter, Jill M, Moreland, Robert B, Brioni, Jorge D, Stewart, Andrew O
Published in Journal of medicinal chemistry (24.08.2006)
Published in Journal of medicinal chemistry (24.08.2006)
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Journal Article
Dopamine D sub(4) receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation
Bitner, Robert S, Nikkel, Arthur L, Otte, Stephani, Martino, Brenda, Barlow, Eve H, Bhatia, Pramila, Stewart, Andrew O, Brioni, Jorge D, Decker, Michael W, Moreland, Robert B
Published in Neuropharmacology (01.01.2006)
Published in Neuropharmacology (01.01.2006)
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Journal Article
Discovery of 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1 H -benzimidazole (ABT-724), a Dopaminergic Agent with a Novel Mode of Action for the Potential Treatment of Erectile Dysfunction
Cowart, Marlon, Latshaw, Steven P., Bhatia, Pramila, Daanen, Jerome F., Rohde, Jeffrey, Nelson, Sherry L., Patel, Meena, Kolasa, Teodozyi, Nakane, Masaki, Uchic, Marie E., Miller, Loan N., Terranova, Marc A., Chang, Renjie, Donnelly-Roberts, Diana L., Namovic, Marian T., Hollingsworth, Peter R., Martino, Brenda R., Lynch, James J., Sullivan, James P., Hsieh, Gin C., Moreland, Robert B., Brioni, Jorge D., Stewart, Andrew O.
Published in Journal of medicinal chemistry (01.07.2004)
Published in Journal of medicinal chemistry (01.07.2004)
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Journal Article
Dopamine D 4 Ligands and Models of Receptor Activation: 2-(4-Pyridin-2-ylpiperazin-1-ylmethyl)-1 H -benzimidazole and Related Heteroarylmethylarylpiperazines Exhibit a Substituent Effect Responsible for Additional Efficacy Tuning
Stewart, Andrew O., Cowart, Marlon D., Moreland, Robert B., Latshaw, Steve P., Matulenko, Mark A., Bhatia, Pramila A., Wang, Xueqing, Daanen, Jerome F., Nelson, Sherry L., Terranova, Marc A., Namovic, Marian T., Donnelly-Roberts, Diana L., Miller, Loan N., Nakane, Masaki, Sullivan, James P., Brioni, Jorge D.
Published in Journal of medicinal chemistry (01.04.2004)
Published in Journal of medicinal chemistry (01.04.2004)
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Journal Article
Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist
Altenbach, RJ, Khilevich, A, Kolasa, T, Rohde, JJ, Bhatia, PA, Patel, MV, Searle, XB, Yang, F, Bunnelle, WH, Tietje, K, Bayburt, EK, Carroll, WA, Meyer, MD, Henry, R, Buckner, SA, Kuk, J, Daza, AV, Milicic, Cain, JC, Kang, CH, Ireland, LM, Carr, TL, Miller, TR, Hancock, AA, Nakane, M, Esbenshade, TA, Brune, ME, O'Neill, AB, Gauvin, DM, Katwala, SP, Holladay, MW, Brioni, JD, Sullivan, JP
Published in Journal of medicinal chemistry (03.06.2004)
Published in Journal of medicinal chemistry (03.06.2004)
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