Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness
Qaisar, Rizwan, Bhaskaran, Shylesh, Ranjit, Rojina, Sataranatarajan, Kavithalakshmi, Premkumar, Pavithra, Huseman, Kendra, Van Remmen, Holly
Published in Redox biology (01.01.2019)
Published in Redox biology (01.01.2019)
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Journal Article
Disparate Central and Peripheral Effects of Circulating IGF-1 Deficiency on Tissue Mitochondrial Function
Pharaoh, Gavin, Owen, Daniel, Yeganeh, Alexander, Premkumar, Pavithra, Farley, Julie, Bhaskaran, Shylesh, Ashpole, Nicole, Kinter, Michael, Van Remmen, Holly, Logan, Sreemathi
Published in Molecular neurobiology (01.03.2020)
Published in Molecular neurobiology (01.03.2020)
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Journal Article
Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance
Bhaskaran, Shylesh, Pharaoh, Gavin, Ranjit, Rojina, Murphy, Ashley, Matsuzaki, Satoshi, Nair, Binoj C, Forbes, Brittany, Gispert, Suzana, Auburger, Georg, Humphries, Kenneth M, Kinter, Michael, Griffin, Timothy M, Deepa, Sathyaseelan S
Published in EMBO reports (01.03.2018)
Published in EMBO reports (01.03.2018)
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Journal Article
Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice
Qaisar, Rizwan, Pharaoh, Gavin, Bhaskaran, Shylesh, Xu, Hongyang, Ranjit, Rojina, Bian, Jan, Ahn, Bumsoo, Georgescu, Constantin, Wren, Jonathan D., Van Remmen, Holly
Published in International journal of molecular sciences (22.12.2020)
Published in International journal of molecular sciences (22.12.2020)
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Journal Article
Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation
Deepa, Sathyaseelan S., Bhaskaran, Shylesh, Ranjit, Rojina, Qaisar, Rizwan, Nair, Binoj C., Liu, Yuhong, Walsh, Michael E., Fok, Wilson C., Van Remmen, Holly
Published in Free radical biology & medicine (01.02.2016)
Published in Free radical biology & medicine (01.02.2016)
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Journal Article
A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice
Bhaskaran, Shylesh, Unnikrishnan, Archana, Ranjit, Rojina, Qaisar, Rizwan, Pharaoh, Gavin, Matyi, Stephanie, Kinter, Michael, Deepa, Sathyaseelan S.
Published in Free radical biology & medicine (01.07.2017)
Published in Free radical biology & medicine (01.07.2017)
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Journal Article
Oxidative stress‐induced dysregulation of excitation–contraction coupling contributes to muscle weakness
Qaisar, Rizwan, Bhaskaran, Shylesh, Premkumar, Pavithra, Ranjit, Rojina, Natarajan, Kavithalakshmi Satara, Ahn, Bumsoo, Riddle, Kaitlyn, Claflin, Dennis R., Richardson, Arlan, Brooks, Susan V., Van Remmen, Holly
Published in Journal of cachexia, sarcopenia and muscle (01.10.2018)
Published in Journal of cachexia, sarcopenia and muscle (01.10.2018)
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Journal Article
Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice
Bhaskaran, Shylesh, Pollock, Natalie, Macpherson, Peter, Ahn, Bumsoo, Piekarz, Katarzyna M., Staunton, Caroline A., Brown, Jacob L., Qaisar, Rizwan, Vasilaki, Aphrodite, Richardson, Arlan, McArdle, Anne, Jackson, Malcolm J., Brooks, Susan V., Van Remmen, Holly
Published in Aging cell (01.10.2020)
Published in Aging cell (01.10.2020)
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Journal Article
Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching
Ahn, Bumsoo, Ranjit, Rojina, Premkumar, Pavithra, Pharaoh, Gavin, Piekarz, Katarzyna M., Matsuzaki, Satoshi, Claflin, Dennis R., Riddle, Kaitlyn, Judge, Jennifer, Bhaskaran, Shylesh, Satara Natarajan, Kavithalakshmi, Barboza, Erika, Wronowski, Benjamin, Kinter, Michael, Humphries, Kenneth M., Griffin, Timothy M., Freeman, Willard M., Richardson, Arlan, Brooks, Susan V., Van Remmen, Holly
Published in Journal of cachexia, sarcopenia and muscle (01.04.2019)
Published in Journal of cachexia, sarcopenia and muscle (01.04.2019)
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Journal Article
Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer's Disease
Xu, Hongyang, Bhaskaran, Shylesh, Piekarz, Katarzyna M, Ranjit, Rojina, Bian, Jan, Kneis, Parker, Ellis, Aubrey, Bhandari, Suyesha, Rice, Heather C, Van Remmen, Holly
Published in Frontiers in aging neuroscience (25.04.2022)
Published in Frontiers in aging neuroscience (25.04.2022)
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Journal Article
Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis
Bhaskaran, Shylesh, Kumar, Gaurav, Thadathil, Nidheesh, Piekarz, Katarzyna M., Mohammed, Sabira, Lopez, Sergio Dominguez, Qaisar, Rizwan, Walton, Dorothy, Brown, Jacob L., Murphy, Ashley, Smith, Nataliya, Saunders, Debra, Beckstead, Michael J., Plafker, Scott, Lewis, Tommy L., Towner, Rheal, Deepa, Sathyaseelan S., Richardson, Arlan, Axtell, Robert C., Van Remmen, Holly
Published in Redox biology (01.02.2023)
Published in Redox biology (01.02.2023)
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Journal Article
Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice
Xu, Hongyang, Piekarz, Katarzyna M., Brown, Jacob L., Bhaskaran, Shylesh, Smith, Nataliya, Towner, Rheal A., Van Remmen, Holly
Published in GeroScience (21.03.2024)
Published in GeroScience (21.03.2024)
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Journal Article
Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype
Sataranatarajan, Kavithalakshmi, Qaisar, Rizwan, Davis, Carol, Sakellariou, Giorgos K, Vasilaki, Aphrodite, Zhang, Yiqiang, Liu, Yuhong, Bhaskaran, Shylesh, McArdle, Anne, Jackson, Malcolm, Brooks, Susan V, Richardson, Arlan, Van Remmen, Holly
Published in Redox biology (01.08.2015)
Published in Redox biology (01.08.2015)
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Journal Article
Molecular changes associated with spinal cord aging
Piekarz, Katarzyna M., Bhaskaran, Shylesh, Sataranatarajan, Kavithalakshmi, Street, Kaitlyn, Premkumar, Pavithra, Saunders, Debra, Zalles, Michelle, Gulej, Rafal, Khademi, Shadi, Laurin, Jaime, Peelor, Rick, Miller, Benjamin F., Towner, Rheal, Van Remmen, Holly
Published in GeroScience (01.04.2020)
Published in GeroScience (01.04.2020)
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Journal Article
Akt/cAMP-Responsive Element Binding Protein/Cyclin D1 Network: A Novel Target for Prostate Cancer Inhibition in Transgenic Adenocarcinoma of Mouse Prostate Model Mediated by Nexrutine, a Phellodendron Amurense Bark Extract
KUMAR, Addanki P, BHASKARAN, Shylesh, GANAPATHY, Manonmani, CROSBY, Katherine, DAVIS, Michael D, KOCHUNOV, Peter, SCHOOLFIELD, John, YEH, I-Tien, TROYER, Dean A, GHOSH, Rita
Published in Clinical cancer research (01.05.2007)
Published in Clinical cancer research (01.05.2007)
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Journal Article
Inhibition of ATR Reverses a Mitochondrial Respiratory Insufficiency
Borror, Megan B, Girotti, Milena, Kar, Adwitiya, Cain, Meghan K, Gao, Xiaoli, MacKay, Vivian L, Herron, Brent, Bhaskaran, Shylesh, Becerra, Sandra, Novy, Nathan, Ventura, Natascia, Johnson, Thomas E, Kennedy, Brian K, Rea, Shane L
Published in Cells (Basel, Switzerland) (24.05.2022)
Published in Cells (Basel, Switzerland) (24.05.2022)
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Journal Article
Synthesis and antiprogestational properties of novel 17-fluorinated steroids
Nickisch, Klaus, Nair, Hareesh B., Kesavaram, Narkunan, Das, Baishakhi, Garfield, Robert, Shi, Shao-Qing, Bhaskaran, Shylesh S., Grimm, Sandra L., Edwards, Dean P.
Published in Steroids (01.09.2013)
Published in Steroids (01.09.2013)
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Journal Article
Akt- and CREB-Mediated Prostate Cancer Cell Proliferation Inhibition by Nexrutine, a Phellodendron amurense Extract
Garcia, Gretchen E., Nicole, Arevalo, Bhaskaran, Shylesh, Gupta, Ashima, Kyprianou, Natasha, Kumar, Addanki P.
Published in Neoplasia (New York, N.Y.) (01.06.2006)
Published in Neoplasia (New York, N.Y.) (01.06.2006)
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Journal Article
Muscle fiber type diversification during exercise and regeneration
Qaisar, Rizwan, Bhaskaran, Shylesh, Van Remmen, Holly
Published in Free radical biology & medicine (01.09.2016)
Published in Free radical biology & medicine (01.09.2016)
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Journal Article
Mouse models used to test the role of reactive oxygen species in aging and age-related chronic diseases
Nguyen, Hoang Van M., Ran, Qitao, Salmon, Adam B., Bumsoo, Ahn, Chiao, Ying Ann, Bhaskaran, Shylesh, Richardson, Arlan
Published in Free radical biology & medicine (20.11.2024)
Published in Free radical biology & medicine (20.11.2024)
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Journal Article