Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
Büller, Harry R, Bethune, Claudette, Bhanot, Sanjay, Gailani, David, Monia, Brett P, Raskob, Gary E, Segers, Annelise, Verhamme, Peter, Weitz, Jeffrey I
Published in The New England journal of medicine (15.01.2015)
Published in The New England journal of medicine (15.01.2015)
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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
Kraus, Daniel, Yang, Qin, Kong, Dong, Banks, Alexander S., Zhang, Lin, Rodgers, Joseph T., Pirinen, Eija, Pulinilkunnil, Thomas C., Gong, Fengying, Wang, Ya-chin, Cen, Yana, Sauve, Anthony A., Asara, John M., Peroni, Odile D., Monia, Brett P., Bhanot, Sanjay, Alhonen, Leena, Puigserver, Pere, Kahn, Barbara B.
Published in Nature (London) (10.04.2014)
Published in Nature (London) (10.04.2014)
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Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes
Digenio, Andres, Dunbar, Richard L, Alexander, Veronica J, Hompesch, Marcus, Morrow, Linda, Lee, Richard G, Graham, Mark J, Hughes, Steven G, Yu, Rosie, Singleton, Walter, Baker, Brenda F, Bhanot, Sanjay, Crooke, Rosanne M
Published in Diabetes care (01.08.2016)
Published in Diabetes care (01.08.2016)
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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice
Lindén, Daniel, Ahnmark, Andrea, Pingitore, Piero, Ciociola, Ester, Ahlstedt, Ingela, Andréasson, Anne-Christine, Sasidharan, Kavitha, Madeyski-Bengtson, Katja, Zurek, Magdalena, Mancina, Rosellina M., Lindblom, Anna, Bjursell, Mikael, Böttcher, Gerhard, Ståhlman, Marcus, Bohlooly-Y, Mohammad, Haynes, William G., Carlsson, Björn, Graham, Mark, Lee, Richard, Murray, Sue, Valenti, Luca, Bhanot, Sanjay, Åkerblad, Peter, Romeo, Stefano
Published in Molecular metabolism (Germany) (01.04.2019)
Published in Molecular metabolism (Germany) (01.04.2019)
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Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers
Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Published in Molecular therapy (01.10.2016)
Published in Molecular therapy (01.10.2016)
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Methionine adenosyltransferase 1a antisense oligonucleotides activate the liver-brown adipose tissue axis preventing obesity and associated hepatosteatosis
Sáenz de Urturi, Diego, Buqué, Xabier, Porteiro, Begoña, Folgueira, Cintia, Mora, Alfonso, Delgado, Teresa C., Prieto-Fernández, Endika, Olaizola, Paula, Gómez-Santos, Beatriz, Apodaka-Biguri, Maider, González-Romero, Francisco, Nieva-Zuluaga, Ane, Ruiz de Gauna, Mikel, Goikoetxea-Usandizaga, Naroa, García-Rodríguez, Juan Luis, Gutierrez de Juan, Virginia, Aurrekoetxea, Igor, Montalvo-Romeral, Valle, Novoa, Eva M., Martín-Guerrero, Idoia, Varela-Rey, Marta, Bhanot, Sanjay, Lee, Richard, Banales, Jesus M., Syn, Wing-Kin, Sabio, Guadalupe, Martínez-Chantar, María L., Nogueiras, Rubén, Aspichueta, Patricia
Published in Nature communications (01.03.2022)
Published in Nature communications (01.03.2022)
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SirT1 Regulates Adipose Tissue Inflammation
GILLUM, Matthew P, KOTAS, Maya E, BANKS, Alexander S, LI QIANG, BHANOT, Sanjay, OLEFSKY, Jerrold M, SEARS, Dorothy D, CAPRIO, Sonia, SHULMAN, Gerald I, ERION, Derek M, KURSAWE, Romy, CHATTERJEE, Paula, NEAD, Kevin T, MUISE, Eric S, HSIAO, Jennifer J, FREDERICK, David W, YONEMITSU, Shin
Published in Diabetes (New York, N.Y.) (01.12.2011)
Published in Diabetes (New York, N.Y.) (01.12.2011)
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Phase 2 Study of the Factor XI Antisense Inhibitor IONIS-FXIRx in Patients With ESRD
Walsh, Michael, Bethune, Claudette, Smyth, Andrew, Tyrwhitt, Jessica, Jung, Shiangtung W., Yu, Rosie Z., Wang, Yanfeng, Geary, Richard S., Weitz, Jeffrey, Bhanot, Sanjay
Published in Kidney international reports (01.02.2022)
Published in Kidney international reports (01.02.2022)
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MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels
Nagarajan, Arvindhan, Petersen, Max C., Nasiri, Ali R., Butrico, Gina, Fung, Annie, Ruan, Hai-Bin, Kursawe, Romy, Caprio, Sonia, Thibodeau, Jacques, Bourgeois-Daigneault, Marie-Claude, Sun, Lisha, Gao, Guangping, Bhanot, Sanjay, Jurczak, Michael J., Green, Michael R., Shulman, Gerald I., Wajapeyee, Narendra
Published in Nature communications (31.08.2016)
Published in Nature communications (31.08.2016)
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A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis
Stark, Romana, Guebre-Egziabher, Fitsum, Zhao, Xiaojian, Feriod, Colleen, Dong, Jianying, Alves, Tiago C., Ioja, Simona, Pongratz, Rebecca L., Bhanot, Sanjay, Roden, Michael, Cline, Gary W., Shulman, Gerald I., Kibbey, Richard G.
Published in The Journal of biological chemistry (14.03.2014)
Published in The Journal of biological chemistry (14.03.2014)
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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
Cantley, Jennifer L., Yoshimura, Toru, Camporez, Joao Paulo G., Zhang, Dongyan, Jornayvaz, Francois R., Kumashiro, Naoki, Guebre-Egziabher, Fitsum, Jurczak, Michael J., Kahn, Mario, Guigni, Bias A., Serr, Julie, Hankin, Joseph, Murphy, Robert C., Cline, Gary W., Bhanot, Sanjay, Manchem, Vara Prasad, Brown, J. Mark, Samuel, Varman T., Shulman, Gerald I.
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (29.01.2013)
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Targeting Pyruvate Carboxylase Reduces Gluconeogenesis and Adiposity and Improves Insulin Resistance
KUMASHIRO, Naoki, BEDDOW, Sara A, KAHN, Mario, PERLER, Bryce K, PUCHOWICZ, Michelle A, VARA PRASAD MANCHEM, BHANOT, Sanjay, STILL, Christopher D, GERHARD, Glenn S, PETERSEN, Kitt Falk, CLINE, Gary W, SHULMAN, Gerald I, VATNER, Daniel F, SAMUEL, Varman T, MAJUMDAR, Sachin K, CANTLEY, Jennifer L, GUEBRE-EGZIABHER, Fitsum, FAT, Ioana, GUIGNI, Blas, JURCZAK, Michael J, BIRKENFELD, Andreas L
Published in Diabetes (New York, N.Y.) (01.07.2013)
Published in Diabetes (New York, N.Y.) (01.07.2013)
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Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice
Yu, Xing Xian, Watts, Lynnetta M, Manchem, Vara Prasad, Chakravarty, Kaushik, Monia, Brett P, McCaleb, Michael L, Bhanot, Sanjay
Published in PloS one (29.07.2013)
Published in PloS one (29.07.2013)
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Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
Galbo, Thomas, Perry, Rachel J., Jurczak, Michael J., Camporez, João-Paulo G., Alves, Tiago C., Kahn, Mario, Guigni, Blas A., Serr, Julle, Zhang, Dongyan, Bhanot, Sanjay, Samuel, Varman T., Shulman, Gerald I.
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (30.07.2013)
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PK/PD modeling of FXI antisense oligonucleotides to bridge the dose‐FXI activity relation from healthy volunteers to end‐stage renal disease patients
Willmann, Stefan, Marostica, Eleonora, Snelder, Nelleke, Solms, Alexander, Jensen, Markus, Lobmeyer, Maximilian, Lensing, Anthonie W. A., Bethune, Claudette, Morgan, Erin, Yu, Rosie Z., Wang, Yanfeng, Jung, Shiangtung W., Geary, Richard, Bhanot, Sanjay
Published in CPT: pharmacometrics and systems pharmacology (01.08.2021)
Published in CPT: pharmacometrics and systems pharmacology (01.08.2021)
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Suppression of Diacylglycerol Acyltransferase-2 (DGAT2), but Not DGAT1, with Antisense Oligonucleotides Reverses Diet-induced Hepatic Steatosis and Insulin Resistance
Choi, Cheol Soo, Savage, David B., Kulkarni, Ameya, Yu, Xing Xian, Liu, Zhen-Xiang, Morino, Katsutaro, Kim, Sheene, Distefano, Alberto, Samuel, Varman T., Neschen, Susanne, Zhang, Dongyan, Wang, Amy, Zhang, Xian-Man, Kahn, Mario, Cline, Gary W., Pandey, Sanjay K., Geisler, John G., Bhanot, Sanjay, Monia, Brett P., Shulman, Gerald I.
Published in The Journal of biological chemistry (03.08.2007)
Published in The Journal of biological chemistry (03.08.2007)
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SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats
Erion, Derek M, Yonemitsu, Shin, Nie, Yongzhan, Nagai, Yoshio, Gillum, Matthew P, Hsiao, Jennifer J, Iwasaki, Takanori, Stark, Romana, Weismann, Dirk, Yu, Xing Xian, Murray, Susan F, Bhanot, Sanjay, Monia, Brett P, Horvath, Tamas L, Gao, Qian, Samuel, Varman T, Shulman, Gerald I
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (07.07.2009)
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ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content
Camporez, João Paulo G., Kanda, Shoichi, Petersen, Max C., Jornayvaz, François R., Samuel, Varman T., Bhanot, Sanjay, Petersen, Kitt Falk, Jurczak, Michael J., Shulman, Gerald I.
Published in Journal of lipid research (01.03.2015)
Published in Journal of lipid research (01.03.2015)
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Role of patatin‐like phospholipase domain‐containing 3 on lipid‐induced hepatic steatosis and insulin resistance in rats
Kumashiro, Naoki, Yoshimura, Toru, Cantley, Jennifer L., Majumdar, Sachin K., Guebre‐Egziabher, Fitsum, Kursawe, Romy, Vatner, Daniel F., Fat, Ioana, Kahn, Mario, Erion, Derek M., Zhang, Xian‐Man, Zhang, Dongyan, Manchem, Vara Prasad, Bhanot, Sanjay, Gerhard, Glenn S., Petersen, Kitt F., Cline, Gary W., Samuel, Varman T., Shulman, Gerald I.
Published in Hepatology (Baltimore, Md.) (01.05.2013)
Published in Hepatology (Baltimore, Md.) (01.05.2013)
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Dyslipidemia and Atherosclerosis Induced by Chronic Intermittent Hypoxia Are Attenuated by Deficiency of Stearoyl Coenzyme A Desaturase
Savransky, Vladimir, Jun, Jonathan, Li, Jianguo, Nanayakkara, Ashika, Fonti, Shannon, Moser, Ann B, Steele, Kimberly E, Schweitzer, Michael A, Patil, Susheel P, Bhanot, Sanjay, Schwartz, Alan R, Polotsky, Vsevolod Y
Published in Circulation research (07.11.2008)
Published in Circulation research (07.11.2008)
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