Predicting Drug Concentration‐Time Profiles in Multiple CNS Compartments Using a Comprehensive Physiologically‐Based Pharmacokinetic Model
Yamamoto, Yumi, Välitalo, Pyry A., Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Beukers, Margot W., van den Berg, Dirk‐Jan, Hartman, Robin, Wong, Yin Cheong, Danhof, Meindert, van Hasselt, John G. C., de Lange, Elizabeth C. M.
Published in CPT: pharmacometrics and systems pharmacology (01.11.2017)
Published in CPT: pharmacometrics and systems pharmacology (01.11.2017)
Get full text
Journal Article
Internalization and desensitization of adenosine receptors
Klaasse, Elisabeth C., IJzerman, Adriaan P., de Grip, Willem J., Beukers, Margot W.
Published in Purinergic signalling (01.03.2008)
Published in Purinergic signalling (01.03.2008)
Get full text
Journal Article
A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization
van der Horst, Eelke, Peironcely, Julio E, Ijzerman, Adriaan P, Beukers, Margot W, Lane, Jonathan R, van Vlijmen, Herman W T, Emmerich, Michael T M, Okuno, Yasushi, Bender, Andreas
Published in BMC bioinformatics (10.06.2010)
Published in BMC bioinformatics (10.06.2010)
Get full text
Journal Article
A two-entropies analysis to identify functional positions in the transmembrane region of class A G protein-coupled receptors
Ye, Kai, Lameijer, Eric-Wubbo M., Beukers, Margot W., IJzerman, Adriaan P.
Published in Proteins, structure, function, and bioinformatics (01.06.2006)
Published in Proteins, structure, function, and bioinformatics (01.06.2006)
Get full text
Journal Article
ZM241385, DPCPX, MRS1706 Are Inverse Agonists with Different Relative Intrinsic Efficacies on Constitutively Active Mutants of the Human Adenosine A2B Receptor
Li, Qilan, Ye, Kai, Blad, Clara C, den Dulk, Hans, Brouwer, Jaap, Ijzerman, Ad P, Beukers, Margot W
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2007)
Get full text
Journal Article
Prediction of human CNS pharmacokinetics using a physiologically-based pharmacokinetic modeling approach
Yamamoto, Yumi, Välitalo, Pyry A., Wong, Yin Cheong, Huntjens, Dymphy R., Proost, Johannes H., Vermeulen, An, Krauwinkel, Walter, Beukers, Margot W., Kokki, Hannu, Kokki, Merja, Danhof, Meindert, van Hasselt, Johan G.C., de Lange, Elizabeth C.M.
Published in European journal of pharmaceutical sciences (15.01.2018)
Published in European journal of pharmaceutical sciences (15.01.2018)
Get full text
Journal Article
Random Mutagenesis of the Human Adenosine A2B Receptor Followed by Growth Selection in Yeast. Identification of Constitutively Active and Gain of Function Mutations
Beukers, Margot W, van Oppenraaij, Joris, van der Hoorn, Patrick P W, Blad, Clara C, den Dulk, Hans, Brouwer, Jaap, IJzerman, Adriaan P
Published in Molecular pharmacology (01.03.2004)
Published in Molecular pharmacology (01.03.2004)
Get full text
Journal Article
2-Amino-6-furan-2-yl-4-substituted Nicotinonitriles as A2A Adenosine Receptor Antagonists
Mantri, Monica, de Graaf, Olivier, van Veldhoven, Jacobus, Göblyös, Anikó, von Frijtag Drabbe Künzel, Jacobien K, Mulder-Krieger, Thea, Link, Regina, de Vries, Henk, Beukers, Margot W, Brussee, Johannes, IJzerman, Adriaan P
Published in Journal of medicinal chemistry (14.08.2008)
Published in Journal of medicinal chemistry (14.08.2008)
Get full text
Journal Article
GPCR structure and activation: an essential role for the first extracellular loop in activating the adenosine A₂B receptor
Peeters, Miriam C, van Westen, Gerard J.P, Guo, Dong, Wisse, Lisanne E, Müller, Christa E, Beukers, Margot W, IJzerman, Adriaan P
Published in The FASEB journal (01.02.2011)
Published in The FASEB journal (01.02.2011)
Get more information
Journal Article
A Prospective Cross-Screening Study on G-Protein-Coupled Receptors: Lessons Learned in Virtual Compound Library Design
Sanders, Marijn P. A, Roumen, Luc, van der Horst, Eelke, Lane, J. Robert, Vischer, Henry F, van Offenbeek, Jody, de Vries, Henk, Verhoeven, Stefan, Chow, Ken Y, Verkaar, Folkert, Beukers, Margot W, McGuire, Ross, Leurs, Rob, IJzerman, Adriaan P, de Vlieg, Jacob, de Esch, Iwan J. P, Zaman, Guido J. R, Klomp, Jan P. G, Bender, Andreas, de Graaf, Chris
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
Get full text
Journal Article
A Series of Ligands Displaying a Remarkable Agonistic−Antagonistic Profile at the Adenosine A1 Receptor
Chang, Lisa C. W, von Frijtag Drabbe Künzel, Jacobien K, Mulder-Krieger, Thea, Spanjersberg, Ronald F, Roerink, Sophie F, van den Hout, Gijs, Beukers, Margot W, Brussee, Johannes, IJzerman, Adriaan P
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
Get full text
Journal Article
Structure-affinity relationships of adenosine A2B receptor ligands
Beukers, Margot W., Meurs, Illiana, IJzerman, Adriaan P.
Published in Medicinal research reviews (01.09.2006)
Published in Medicinal research reviews (01.09.2006)
Get full text
Journal Article
Characterization of [3H]LUF5834: A novel non-ribose high-affinity agonist radioligand for the adenosine A1 receptor
LANE, J. Robert, KLAASSE, Elisabeth, LIN, Judy, VAN BRUCHEM, John, BEUKERS, Margot W, IJZERMAN, Adriaan P
Published in Biochemical pharmacology (15.10.2010)
Published in Biochemical pharmacology (15.10.2010)
Get full text
Journal Article
2,4,6-Trisubstituted Pyrimidines as a New Class of Selective Adenosine A1 Receptor Antagonists
Chang, Lisa C. W, Spanjersberg, Ronald F, von Frijtag Drabbe Künzel, Jacobien K, Mulder-Krieger, Thea, van den Hout, Gijs, Beukers, Margot W, Brussee, Johannes, IJzerman, Adriaan P
Published in Journal of medicinal chemistry (16.12.2004)
Published in Journal of medicinal chemistry (16.12.2004)
Get full text
Journal Article
Synthesis and use of FSCPX, an irreversible adenosine A1 antagonist, as a 'Receptor knock-down' tool
VAN MUIJLWIJK-KOEZEN, Jacqueline E, TIMMERMAN, Henk, VAN DER SLUIS, Richard P, VAN DE STOLPE, Andrea C, MENGE, Wiro M. P. B, BEUKERS, Margot W, VAN DER GRAAF, Piet H, DE GROOTE, Miriam, IJZERMAN, Adriaan P
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
Published in Bioorganic & medicinal chemistry letters (26.03.2001)
Get full text
Journal Article
Techniques: how to boost GPCR mutagenesis studies using yeast
Beukers, Margot W, Ijzerman, Adriaan P
Published in Trends in pharmacological sciences (Regular ed.) (01.10.2005)
Published in Trends in pharmacological sciences (Regular ed.) (01.10.2005)
Get full text
Journal Article
A new generation of adenosine receptor antagonists: From di- to trisubstituted aminopyrimidines
van Veldhoven, Jacobus P.D., Chang, Lisa C.W., von Frijtag Drabbe Künzel, Jacobien K., Mulder-Krieger, Thea, Struensee-Link, Regina, Beukers, Margot W., Brussee, Johannes, IJzerman, Adriaan P.
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
Get full text
Journal Article
tGRAP, the G-protein coupled receptors mutant database
Edvardsen, Oyvind, Reiersen, Anne Lise, Beukers, Margot W, Kristiansen, Kurt
Published in Nucleic acids research (01.01.2002)
Published in Nucleic acids research (01.01.2002)
Get full text
Journal Article