Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2
Harman, Maximilian A. J., Stanway, Steven J., Scott, Heather, Demydchuk, Yuliya, Bezerra, Gustavo Arruda, Pellegrino, Simone, Chen, Liuhong, Brear, Paul, Lulla, Aleksei, Hyvönen, Marko, Beswick, Paul J., Skynner, Michael J.
Published in Journal of medicinal chemistry (27.07.2023)
Published in Journal of medicinal chemistry (27.07.2023)
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BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
Rigby, Michael, Bennett, Gavin, Chen, Liuhong, Mudd, Gemma E, Harrison, Helen, Beswick, Paul J, Van Rietschoten, Katerine, Watcham, Sophie M, Scott, Heather S, Brown, Amy N, Park, Peter U, Campbell, Carly, Haines, Eric, Lahdenranta, Johanna, Skynner, Michael J, Jeffrey, Phil, Keen, Nicholas, Lee, Kevin
Published in Molecular cancer therapeutics (02.12.2022)
Published in Molecular cancer therapeutics (02.12.2022)
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Gold-Mediated Multiple Cysteine Arylation for the Construction of Highly Constrained Bicycle Peptides
Mudd, Gemma E., Stanway, Steven J., Witty, David R., Thomas, Alex, Baldo, Silvia, Bond, Andrew D., Beswick, Paul, Highton, Adrian
Published in Bioconjugate chemistry (17.08.2022)
Published in Bioconjugate chemistry (17.08.2022)
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Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
King, Oliver N F, Li, Xuan Shirley, Sakurai, Masaaki, Kawamura, Akane, Rose, Nathan R, Ng, Stanley S, Quinn, Amy M, Rai, Ganesha, Mott, Bryan T, Beswick, Paul, Klose, Robert J, Oppermann, Udo, Jadhav, Ajit, Heightman, Tom D, Maloney, David J, Schofield, Christopher J, Simeonov, Anton
Published in PloS one (23.11.2010)
Published in PloS one (23.11.2010)
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African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase
West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth, Ward, Simon E.
Published in European journal of medicinal chemistry (01.12.2017)
Published in European journal of medicinal chemistry (01.12.2017)
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Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor
ABDI, Muna H, BESWICK, Paul J, LEJEUNE, Clarisse L, LIVERMORE, David G, MEDHURST, Stephen J, MICHEL, Anton D, MOSES, Andrew P, PAGE, Lee, PATEL, Sadhana, ROMAN, Shilina A, SENGER, Stefan, SLINGSBY, Brian, BILLINTON, Andy, STEADMAN, Jon G. A, STEVENS, Alexander J, WALTER, Daryl S, CHAMBERS, Laura J, CHARLTON, Andrew, COLLINS, Sue D, COLLIS, Katharine L, DEAN, David K, FONFRIA, Elena, GLEAVE, Robert J
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X7 antagonists
GLEAVE, Robert J, WALTER, Daryl S, BESWICK, Paul J, FONFRIA, Elena, MICHEL, Anton D, ROMAN, Shilina A, TANG, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists
Gleave, Robert J, Walter, Daryl S, Beswick, Paul J, Fonfria, Elena, Michel, Anton D, Roman, Shilina A, Tang, Sac-Pham
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J, Billinton, Andy, Collis, Katharine L, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G A, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Synthesis and evaluation of 3-amino-6-aryl-pyridazines as selective CB2 agonists for the treatment of inflammatory pain
GLEAVE, Robert J, BESWICK, Paul J, ROOMANS, Susan, SLINGSBY, Brian P, SWARBRICK, Martin E, BROWN, Andrew J, GIBLIN, Gerard M. P, GOLDSMITH, Paul, HASLAM, Carl P, MITCHELL, William L, NICHOLSON, Neville H, PAGE, Lee W, PATEL, Sadhana
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
Published in Bioorganic & medicinal chemistry letters (15.01.2010)
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The role of the cylooxygenase pathway in nociception and pain
Bingham, Sharon, Beswick, Paul J., Blum, David E., Gray, Norman M., Chessell, Iain P.
Published in Seminars in cell & developmental biology (01.10.2006)
Published in Seminars in cell & developmental biology (01.10.2006)
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Journal Article
Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X7 receptor
Abberley, Lee, Bebius, Aude, Beswick, Paul J., Billinton, Andy, Collis, Katharine L., Dean, David K., Fonfria, Elena, Gleave, Robert J., Medhurst, Stephen J., Michel, Anton D., Moses, Andrew P., Patel, Sadhana, Roman, Shilina A., Scoccitti, Tiziana, Smith, Beverley, Steadman, Jon G.A., Walter, Daryl S.
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
Published in Bioorganic & medicinal chemistry letters (15.11.2010)
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Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor
Beswick, Paul J, Billinton, Andy, Chambers, Laura J, Dean, David K, Fonfria, Elena, Gleave, Robert J, Medhurst, Stephen J, Michel, Anton D, Moses, Andrew P, Patel, Sadhana, Roman, Shilina A, Roomans, Sue, Senger, Stefan, Stevens, Alexander J, Walter, Daryl S
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
Published in Bioorganic & medicinal chemistry letters (01.08.2010)
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Journal Article
Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor
CHAMBERS, Laura J, STEVENS, Alexander J, THEOBALD, Pam J, BESWICK, Paul J, GLEAVE, Robert J, ROMAN, Shilina A, SENGER, Stefan, MOSES, Andrew P, MICHEL, Anton D, WALTER, Daryl S, DAVIES, David J, LIVERMORE, David G, FONFRIA, Elena, DEMONT, Emmanuel H, VIMAL, Mythily
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
Published in Bioorganic & medicinal chemistry letters (15.05.2010)
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Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach
Beswick, Paul J., Blackaby, Andrew P., Bountra, Chas, Brown, Terry, Browning, Kerry, Campbell, Ian B., Corfield, John, Gleave, Robert J., Guntrip, Steve B., Hall, Richard M., Hindley, Sean, Lambeth, Paul F., Lucas, Fiona, Mathews, Neil, Naylor, Alan, Player, Hazel, Price, Helen S., Sidebottom, Phillip J., Taylor, Nicholas L., Webb, Graham, Wiseman, Joanne
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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