Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors
Zhou, Yuefen, Chow, Chun, Murphy, Douglas E., Sun, Zhongxiang, Bertolini, Thomas, Froelich, Jamie M., Webber, Stephen E., Hermann, Thomas, Wall, Daniel
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Synthesis of new pyridazinone derivatives: 2,6-disubstituted 5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters
Li, Lian-Sheng, Zhou, Yuefen, Zhao, Jingjing, Dragovich, Peter S., Stankovic, Nebojsa, Bertolini, Thomas M., Murphy, Douglas E., Sun, Zhongxiang, Tran, Chinh V., Ayida, Benjamin K., Ruebsam, Frank, Webber, Stephen E.
Published in Synthesis (Stuttgart) (02.11.2007)
Published in Synthesis (Stuttgart) (02.11.2007)
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Journal Article
Comment on “Anti-aging effects of ingenol mebutate for patients with actinic keratosis” and phenol-croton oil peelings
Wambier, Carlos Gustavo, Lee, Kachiu Cecilia, Bertolini, Thomas Michael, Rullan, Peter P., Beltrame, Flavio Luis
Published in Journal of the American Academy of Dermatology (01.06.2019)
Published in Journal of the American Academy of Dermatology (01.06.2019)
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Journal Article
About "Anti-aging effects of ingenol mebutate for patients with actinic keratosis" and phenol-croton oil peelings
Wambier, Carlos Gustavo, Lee, Kachiu Cecilia, Bertolini, Thomas Michael, Rullan, Peter P, Beltrame, Flavio Luis
Published in Journal of the American Academy of Dermatology (01.02.2019)
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Published in Journal of the American Academy of Dermatology (01.02.2019)
Journal Article
Regiospecific synthesis of 1,5-disubstituted-1H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates
Dragovich, Peter S., Bertolini, Thomas M., Ayida, Benjamin K., Li, Lian-Sheng, Murphy, Douglas E., Ruebsam, Frank, Sun, Zhongxiang, Zhou, Yuefen
Published in Tetrahedron (29.01.2007)
Published in Tetrahedron (29.01.2007)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments
Li, Lian-Sheng, Zhou, Yuefen, Murphy, Douglas E., Stankovic, Nebojsa, Zhao, Jingjing, Dragovich, Peter S., Bertolini, Thomas, Sun, Zhongxiang, Ayida, Benjamin, Tran, Chinh V., Ruebsam, Frank, Webber, Stephen E., Shah, Amit M., Tsan, Mei, Showalter, Richard E., Patel, Rupal, LeBrun, Laurie A., Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Kamran, Ruhi, Brooks, Jennifer, Sergeeva, Maria V., Kirkovsky, Leo, Zhao, Qiang, Kissinger, Charles R.
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
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Journal Article
Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters
Murphy, Douglas E., Dragovich, Peter S., Ayida, Benjamin K., Bertolini, Thomas M., Li, Lian-Sheng, Ruebsam, Frank, Stankovic, Nebojsa S., Sun, Zhongxiang, Zhao, Jingjing, Zhou, Yuefen
Published in Tetrahedron letters (28.01.2008)
Published in Tetrahedron letters (28.01.2008)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments
Li, Lian-Sheng, Zhou, Yuefen, Murphy, Douglas E, Stankovic, Nebojsa, Zhao, Jingjing, Dragovich, Peter S, Bertolini, Thomas, Sun, Zhongxiang, Ayida, Benjamin, Tran, Chinh V, Ruebsam, Frank, Webber, Stephen E, Shah, Amit M, Tsan, Mei, Showalter, Richard E, Patel, Rupal, Lebrun, Laurie A, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Kamran, Ruhi, Brooks, Jennifer, Sergeeva, Maria V, Kirkovsky, Leo, Zhao, Qiang, Kissinger, Charles R
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'- dihydro-1' lambda super(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H- pyridazin-3-ones: Part 4. Optimization of DMPK properties
Sergeeva, Maria V, Zhou, Yuefen, Bartkowski, Darian M, Nolan, Thomas G, Norris, Daniel A, Okamoto, Ellen, Kirkovsky, Leo, Kamran, Ruhi, LeBrun, Laurie A, Tsan, Mei, Patel, Rupal, Shah, Amit M, Lardy, Matthew, Gobbi, Alberto, Li, Lian-Sheng, Zhao, Jingjing, Bertolini, Thomas, Stankovic, Nebojsa, Sun, Zhongxiang, Murphy, Douglas E, Webber, Stephen E, Dragovich, Peter S
Published in Bioorganic & medicinal chemistry (01.06.2008)
Published in Bioorganic & medicinal chemistry (01.06.2008)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1 '4'-dihydro-1λ-benzo[1',2',4']thiadiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties
SERGEEVA, Maria V, YUEFEN ZHOU, PATEL, Rupal, SHAH, Amit M, LARDY, Matthew, GOBBI, Alberto, LI, Lian-Sheng, JINGJING ZHAO, BERTOLINI, Thomas, STANKOVIC, Nebojsa, ZHONGXIANG SUN, MURPHY, Douglas E, BARTKOWSKI, Darian M, WEBBER, Stephen E, DRAGOVICH, Peter S, NOLAN, Thomas G, NORRIS, Daniel A, OKAMOTO, Ellen, KIRKOVSKY, Leo, KAMRAN, Ruhi, LEBRUN, Laurie A, TSAN, Mei
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
Published in Bioorganic & medicinal chemistry letters (01.06.2008)
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Journal Article
Regiospecific synthesis of 1,5-disubstituted-1 H-pyrazoles containing differentiated 3,4-dicarboxylic acid esters via Suzuki coupling of the corresponding 5-trifluoromethane sulfonates
Dragovich, Peter S., Bertolini, Thomas M., Ayida, Benjamin K., Li, Lian-Sheng, Murphy, Douglas E., Ruebsam, Frank, Sun, Zhongxiang, Zhou, Yuefen
Published in Tetrahedron (2007)
Published in Tetrahedron (2007)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ 6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2 H-pyridazin-3-ones: Part 4. Optimization of DMPK properties
Sergeeva, Maria V., Zhou, Yuefen, Bartkowski, Darian M., Nolan, Thomas G., Norris, Daniel A., Okamoto, Ellen, Kirkovsky, Leo, Kamran, Ruhi, LeBrun, Laurie A., Tsan, Mei, Patel, Rupal, Shah, Amit M., Lardy, Matthew, Gobbi, Alberto, Li, Lian-Sheng, Zhao, Jingjing, Bertolini, Thomas, Stankovic, Nebojsa, Sun, Zhongxiang, Murphy, Douglas E., Webber, Stephen E., Dragovich, Peter S.
Published in Bioorganic & medicinal chemistry letters (2008)
Published in Bioorganic & medicinal chemistry letters (2008)
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Journal Article
Novel HCV NS5B polymerase inhibitors derived from 4-1',1'-dioxo-1',4'-dihydro1'λ6-benzo(1',1',4'] thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3. Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments
LI, Lian-Sheng, YUEFEN ZHOU, RUEBSAM, Frank, WEBBER, Stephen E, SHAH, Amit M, TSAN, Mei, SHOWALTER, Richard E, PATEL, Rupal, LEBRUN, Laurie A, BARTKOWSKI, Darian M, NOLAN, Thomas G, NORRIS, Daniel A, MURPHY, Douglas E, KAMRAN, Ruhi, BROOKS, Jennifer, SERGEEVA, Maria V, KIRKOVSKY, Leo, QIANG ZHAO, KISSINGER, Charles R, STANKOVIC, Nebojsa, JINGJING ZHAO, DRAGOVICH, Peter S, BERTOLINI, Thomas, ZHONGXIANG SUN, AYIDA, Benjamin, TRAN, Chinh V
Published in Bioorganic & medicinal chemistry letters (2008)
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Published in Bioorganic & medicinal chemistry letters (2008)
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