Application of an "inhalation by design" approach to the identification and in-vitro evaluation of novel purine based PI3Kd inhibitors
Mazzucato, Roberta, Roberti, Marinella, Capelli, Anna Maria, Rancati, Fabio, Biagetti, Matteo, Fiorelli, Claudio, Bruno, Paolo, Ronchi, Paolo, Bertolini, Serena, Corsi, Mauro, Pala, Daniele
Published in European journal of medicinal chemistry (05.06.2023)
Published in European journal of medicinal chemistry (05.06.2023)
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Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation
Bruno, Paolo, Micoli, Alessandra, Corsi, Mauro, Pala, Daniele, Guariento, Sara, Fiorelli, Claudio, Ronchi, Paolo, Fioni, Alessandro, Gallo, Paola Maria, Marenghi, Giulia, Bertolini, Serena, Capacchi, Silvia, Mileo, Valentina, Biagetti, Matteo, Capelli, Anna Maria
Published in Journal of medicinal chemistry (11.07.2024)
Published in Journal of medicinal chemistry (11.07.2024)
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Journal Article
Application of an “inhalation by design” approach to the identification and in-vitro evaluation of novel purine based PI3Kδ inhibitors
Mazzucato, Roberta, Roberti, Marinella, Capelli, Anna Maria, Rancati, Fabio, Biagetti, Matteo, Fiorelli, Claudio, Bruno, Paolo, Ronchi, Paolo, Bertolini, Serena, Corsi, Mauro, Pala, Daniele
Published in European journal of medicinal chemistry (05.06.2023)
Published in European journal of medicinal chemistry (05.06.2023)
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Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
Moretto, Nadia, Bertolini, Serena, Iadicicco, Claudia, Marchini, Gessica, Kaur, Manminder, Volpi, Giorgia, Patacchini, Riccardo, Singh, Dave, Facchinetti, Fabrizio
Published in American journal of physiology. Lung cellular and molecular physiology (15.11.2012)
Published in American journal of physiology. Lung cellular and molecular physiology (15.11.2012)
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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 24(6-Amino-9H-purin-9-yl)methyl)-5-methyl-3-(o-tolyl)quinazolin-4(3H)-one (IC87114) and Its Conformationally Restricted Analogs
Lodola, Alessio, Bertolini, Serena, Biagetti, Matteo, Capacchi, Silvia, Facchinetti, Fabrizio, Gallo, Paola Maria, Pappani, Alice, Mor, Marco, Pala, Daniele, Rivara, Silvia, Visentin, Filippo, Corsi, Mauro, Capelli, Anna Maria
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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Atropisomerism and Conformational Equilibria: Impact on PI3Kδ Inhibition of 2‑((6-Amino‑9H‑purin-9-yl)methyl)-5-methyl-3‑(o‑tolyl)quinazolin-4(3H)‑one (IC87114) and Its Conformationally Restricted Analogs
Lodola, Alessio, Bertolini, Serena, Biagetti, Matteo, Capacchi, Silvia, Facchinetti, Fabrizio, Gallo, Paola Maria, Pappani, Alice, Mor, Marco, Pala, Daniele, Rivara, Silvia, Visentini, Filippo, Corsi, Mauro, Capelli, Anna Maria
Published in Journal of medicinal chemistry (25.05.2017)
Published in Journal of medicinal chemistry (25.05.2017)
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A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases
Ghigo, Alessandra, Murabito, Alessandra, Sala, Valentina, Pisano, Anna Rita, Bertolini, Serena, Gianotti, Ambra, Caci, Emanuela, Montresor, Alessio, Premchandar, Aiswarya, Pirozzi, Flora, Ren, Kai, Della Sala, Angela, Mergiotti, Marco, Richter, Wito, de Poel, Eyleen, Matthey, Michaela, Caldrer, Sara, Cardone, Rosa A, Civiletti, Federica, Costamagna, Andrea, Quinney, Nancy L, Butnarasu, Cosmin, Visentin, Sonja, Ruggiero, Maria Rosaria, Baroni, Simona, Crich, Simonetta Geninatti, Ramel, Damien, Laffargue, Muriel, Tocchetti, Carlo G, Levi, Renzo, Conti, Marco, Lu, Xiao-Yun, Melotti, Paola, Sorio, Claudio, De Rose, Virginia, Facchinetti, Fabrizio, Fanelli, Vito, Wenzel, Daniela, Fleischmann, Bernd K, Mall, Marcus A, Beekman, Jeffrey, Laudanna, Carlo, Gentzsch, Martina, Lukacs, Gergely L, Pedemonte, Nicoletta, Hirsch, Emilio
Published in Science translational medicine (30.03.2022)
Published in Science translational medicine (30.03.2022)
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Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
MORETTO, Nadia, BERTOLINI, Serena, IADICICCO, Claudia, MARCHINI, Gessica, KAUR, Manminder, VOLPI, Giorgia, PATACCHINI, Riccardo, SINGH, Dave, FACCHINETTI, Fabrizio
Published in American journal of physiology. Lung cellular and molecular physiology (2012)
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Published in American journal of physiology. Lung cellular and molecular physiology (2012)
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