Discovery of a Potent and Selective Prostaglandin D2 Receptor Antagonist, [(3R)-4-(4-Chloro- benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic Acid (MK-0524)
Sturino, Claudio F, O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P, Chauret, Nathalie, Day, Stephen H, Lévesque, Jean-François, Seto, Carmai, Silva, Jose H, Trimble, Laird A, Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M, Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A, Wang, Zhaoyin, Zamboni, Robert, Young, Robert N, Metters, Kathleen M
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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A generally applicable method for assessing the electrophilicity and reactivity of diverse nitrile-containing compounds
Oballa, Renata M., Truchon, Jean-François, Bayly, Christopher I., Chauret, Nathalie, Day, Stephen, Crane, Sheldon, Berthelette, Carl
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
Published in Bioorganic & medicinal chemistry letters (15.02.2007)
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Journal Article
High-Sensitivity NanoLC−MS/MS Analysis of Urinary Desmosine and Isodesmosine
Boutin, Michel, Berthelette, Carl, Gervais, François G, Scholand, Mary-Beth, Hoidal, John, Leppert, Mark F, Bateman, Kevin P, Thibault, Pierre
Published in Analytical chemistry (Washington) (01.03.2009)
Published in Analytical chemistry (Washington) (01.03.2009)
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Journal Article
Identification of prostaglandin D2 receptor antagonists based on a tetrahydropyridoindole scaffold
BEAULIEU, Christian, GUAY, Daniel, DENIS, Danielle, GREIG, Gillian, MATHIEU, Marie-Claude, O'NEILL, Gary, ZHAOYIN WANG, LEBLANC, Yves, ROY, Patrick, DUFRESNE, Claude, ZAMBONI, Robert, BERTHELETTE, Carl, DAY, Stephen, TSOU, Nancy
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
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Journal Article
An expedient approach to E, Z-dienes using the Julia olefination
Charette, André B, Berthelette, Carl, St-Martin, David
Published in Tetrahedron letters (30.07.2001)
Published in Tetrahedron letters (30.07.2001)
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Journal Article
Discovery of 4-{1-[({1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl}carbonyl)amino]cyclopropyl}benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain
Colucci, John, Boyd, Michael, Berthelette, Carl, Chiasson, Jean-Francois, Wang, Zhaoyin, Ducharme, Yves, Friesen, Rick, Wrona, Mark, Levesque, Jean-Francois, Denis, Danielle, Mathieu, Marie-Claude, Stocco, Rino, Therien, Alex G., Clarke, Patsy, Rowland, Steve, Xu, Daigen, Han, Yongxin
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
Published in Bioorganic & medicinal chemistry letters (01.06.2010)
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Journal Article
Identification of an indole series of prostaglandin D2 receptor antagonists
STURINO, Claudio F, LACHANCE, Nicolas, CAUCHON, Elizabeth, CARRIERE, Marie-Claude, DENIS, Danielle, GREIG, Gillian, KARGMAN, Stacia, LAMONTAGNE, Sonia, MATHIEU, Marie-Claude, SAWYER, Nicole, SLIPETZ, Deborah, O'NEILL, Gary, BOYD, Michael, ZHAOYIN WANG, ZAMBONI, Robert, METTERS, Kathleen M, YOUNG, Robert N, BERTHELETTE, Carl, LABELLE, Marc, LIANHAI LI, ROY, Bruno, SCHEIGETZ, John, TSOU, Nancy, BRIDEAU, Christine
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
Published in Bioorganic & medicinal chemistry letters (01.06.2006)
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Journal Article
Asymmetric synthesis of diarylmethylamines: preparation of selective opioid delta receptor ligands
Delorme, Daniel, Berthelette, Carl, Lavoie, Rico, Roberts, Edward
Published in Tetrahedron: asymmetry (27.11.1998)
Published in Tetrahedron: asymmetry (27.11.1998)
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Journal Article
Base-catalyzed deuterium and tritium labeling of aryl methyl sulfones
Scheigetz, John, Berthelette, Carl, Li, Chun, Zamboni, Robert J.
Published in Journal of labelled compounds & radiopharmaceuticals (30.10.2004)
Published in Journal of labelled compounds & radiopharmaceuticals (30.10.2004)
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Journal Article
Discovery of a potent and selective prostaglandin D-2 receptor antagonist, [(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524)
Sturino, Claudio F., O'Neill, Gary, Lachance, Nicolas, Boyd, Michael, Berthelette, Carl, Labelle, Marc, Li, Lianhai, Roy, Bruno, Scheigetz, John, Tsou, Nancy, Aubin, Yves, Bateman, Kevin P., Chauret, Nathalie, Day, Stephen H., Levesque, Jean-Francois, Seto, Carmai, Silva, Jose H., Trimble, Laird A., Carriere, Marie-Claude, Denis, Danielle, Greig, Gillian, Kargman, Stacia, Lamontagne, Sonia, Mathieu, Marie-Claude, Sawyer, Nicole, Slipetz, Deborah, Abraham, William M., Jones, Tom, McAuliffe, Malia, Piechuta, Hana, Nicoll-Griffith, Deborah A., Wang, Zhaoyin, Zamboni, Robert, Young, Robert N., Metters, Kathleen M.
Published in Journal of medicinal chemistry (22.02.2007)
Published in Journal of medicinal chemistry (22.02.2007)
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Journal Article
Stereoselective Synthesis of Z Alkenyl Halides via Julia Olefination
Lebrun, Marie-Eve, Le Marquand, Paul, Berthelette, Carl
Published in Journal of organic chemistry (03.03.2006)
Published in Journal of organic chemistry (03.03.2006)
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Journal Article
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases
Gallant, Michel, Beaulieu, Christian, Berthelette, Carl, Colucci, John, Crackower, Michael A., Dalton, Chad, Denis, Danielle, Ducharme, Yves, Friesen, Richard W., Guay, Daniel, Gervais, François G., Hamel, Martine, Houle, Robert, Krawczyk, Connie M., Kosjek, Birgit, Lau, Stephen, Leblanc, Yves, Lee, Ernest E., Levesque, Jean-François, Mellon, Christophe, Molinaro, Carmela, Mullet, Wayne, O’Neill, Gary P., O’Shea, Paul, Sawyer, Nicole, Sillaots, Susan, Simard, Daniel, Slipetz, Deborah, Stocco, Rino, Sørensen, Dan, Truong, Vouy Linh, Wong, Elizabeth, Wu, Jin, Zaghdane, Helmi, Wang, Zhaoyin
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
Azaindoles as potent CRTH2 receptor antagonists
Simard, Daniel, Leblanc, Yves, Berthelette, Carl, Zaghdane, M. Helmi, Molinaro, Carmela, Wang, Zhaoyin, Gallant, Michel, Lau, Stephen, Thao, Trinh, Hamel, Martine, Stocco, Rino, Sawyer, Nicole, Sillaots, Susan, Gervais, Francois, Houle, Robert, Lévesque, Jean-François
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
Published in Bioorganic & medicinal chemistry letters (15.01.2011)
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Journal Article
New indole amide derivatives as potent CRTH2 receptor antagonists
Zaghdane, Helmi, Boyd, Michael, Colucci, John, Simard, Daniel, Berthelette, Carl, Leblanc, Yves, Wang, Zhaoyin, Houle, Robert, Lévesque, Jean François, Molinaro, Carmela, Hamel, Martine, Stocco, Rino, Sawyer, Nicole, Sillaots, Susan, Gervais, François, Gallant, Michel
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
Published in Bioorganic & medicinal chemistry letters (01.06.2011)
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Journal Article
Identification of prostaglandin D 2 receptor antagonists based on a tetrahydropyridoindole scaffold
Beaulieu, Christian, Guay, Daniel, Wang, Zhaoyin, Leblanc, Yves, Roy, Patrick, Dufresne, Claude, Zamboni, Robert, Berthelette, Carl, Day, Stephen, Tsou, Nancy, Denis, Danielle, Greig, Gillian, Mathieu, Marie-Claude, O’Neill, Gary
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
Published in Bioorganic & medicinal chemistry letters (15.04.2008)
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