LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]
Quinet, Elaine M., Basso, Michael D., Halpern, Anita R., Yates, David W., Steffan, Robert J., Clerin, Valerie, Resmini, Christine, Keith, James C., Berrodin, Thomas J., Feingold, Irene, Zhong, Wenyan, Hartman, Helen B., Evans, Mark J., Gardell, Stephen J., DiBlasio-Smith, Elizabeth, Mounts, William M., LaVallie, Edward R., Wrobel, Jay, Nambi, Ponnal, Vlasuk, George P.
Published in Journal of lipid research (01.12.2009)
Published in Journal of lipid research (01.12.2009)
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1-Methyl-1H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists
KERN, Jeffrey C, TEREFENKO, Eugene, TRYBULSKI, Eugene, BERRODIN, Thomas J, COHEN, Jeffrey, WINNEKER, Richard C, YUDT, Matthew R, ZHIMING ZHANG, YUAN ZHU, PUWEN ZHANG
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
Published in Bioorganic & medicinal chemistry letters (15.08.2010)
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Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening
Tian, Xinrong, Suarez, Dominic, Thomson, Douglas, Li, William, King, Elizabeth A., LaFrance, Louis, Boehm, Jeffrey, Barton, Linda, Di Marco, Christina, Martyr, Cuthbert, Thalji, Reema, Medina, Jesus, Knight, Steven, Heerding, Dirk, Gao, Enoch, Nartey, Eldridge, Cecconie, Ted, Nixon, Christopher, Zhang, Guofeng, Berrodin, Thomas J., Phelps, Christopher, Patel, Amish, Bai, Xiaopeng, Lind, Ken, Prabhu, Ninad, Messer, Jeffrey, Zhu, Zhengrong, Shewchuk, Lisa, Reid, Rob, Graves, Alan P., McHugh, Charles, Mangatt, Biju
Published in Journal of medicinal chemistry (10.11.2022)
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Cell-Based Drug Discovery: Identification and Optimization of Small Molecules that Reduce c‑MYC Protein Levels in Cells
Medina, Jesús R, Tian, Xinrong, Li, William H, Suarez, Dominic, Mack, James F, LaFrance, Louis, Martyr, Cuthbert, Brackley, James, Di Marco, Christina, Rivero, Ralph, Heerding, Dirk A, McHugh, Charles, Minthorn, Elisabeth, Bhaskar, Aishwarya, Rubin, Jacob, Butticello, Michael, Carpenter, Christopher, Nartey, Eldridge N, Berrodin, Thomas J, Kallal, Lorena A, Mangatt, Biju
Published in Journal of medicinal chemistry (11.11.2021)
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Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity
Berrodin, Thomas J, Shen, Qi, Quinet, Elaine M, Yudt, Matthew R, Freedman, Leonard P, Nagpal, Sunil
Published in Molecular pharmacology (01.12.2010)
Published in Molecular pharmacology (01.12.2010)
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Differential Biochemical and Cellular Actions of Premarin Estrogens: Distinct Pharmacology of Bazedoxifene-Conjugated Estrogens Combination
Berrodin, Thomas J, Chang, Ken C. N, Komm, Barry S, Freedman, Leonard P, Nagpal, Sunil
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2009)
Published in Molecular endocrinology (Baltimore, Md.) (01.01.2009)
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Identification of Phenylsulfone-Substituted Quinoxaline (WYE-672) as a Tissue Selective Liver X-receptor (LXR) Agonist
Hu, Baihua, Unwalla, Rayomand J, Goljer, Igor, Jetter, James W, Quinet, Elaine M, Berrodin, Thomas J, Basso, Michael D, Feingold, Irene B, Nilsson, Annika Goos, Wilhelmsson, Anna, Evans, Mark J, Wrobel, Jay E
Published in Journal of medicinal chemistry (22.04.2010)
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The Lecanindoles, Nonsteroidal Progestins from the Terrestrial Fungus Verticillium lecanii 6144
Roll, Deborah M, Barbieri, Laurel R, Bigelis, Ramunas, McDonald, Leonard A, Arias, Daniel A, Chang, Li-Ping, Singh, Maya P, Luckman, Scott W, Berrodin, Thomas J, Yudt, Matthew R
Published in Journal of natural products (Washington, D.C.) (30.11.2009)
Published in Journal of natural products (Washington, D.C.) (30.11.2009)
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Discovery of a novel mechanism of steroid receptor antagonism: WAY-255348 modulates progesterone receptor cellular localization and promoter interactions
Yudt, Matthew R., Russo, Louise A., Berrodin, Thomas J., Jelinsky, Scott A., Ellis, Debra, Cohen, Jeff C., Cooch, Neil, Haglund, Elizabeth, Unwalla, Raymond J., Fensome, Andrew, Wrobel, Jay, Zhang, Zhiming, Nagpal, Sunil, Winneker, Richard C.
Published in Biochemical pharmacology (01.12.2011)
Published in Biochemical pharmacology (01.12.2011)
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Novel progesterone receptor modulators with gene selective and context-dependent partial agonism
Berrodin, Thomas J., Jelinsky, Scott A., Graciani, Nilsa, Butera, John A., Zhang, Zhiming, Nagpal, Sunil, Winneker, Richard C., Yudt, Matthew R.
Published in Biochemical pharmacology (15.01.2009)
Published in Biochemical pharmacology (15.01.2009)
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A Transcriptional Coactivator, Steroid Receptor Coactivator-3, Selectively Augments Steroid Receptor Transcriptional Activity
Suen, Chen-Shian, Berrodin, Thomas J., Mastroeni, Robert, Cheskis, Boris J., Lyttle, C. Richard, Frail, Donald E.
Published in The Journal of biological chemistry (16.10.1998)
Published in The Journal of biological chemistry (16.10.1998)
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5-Aryl indanones and derivatives as non-steroidal progesterone receptor modulators
Kern, Jeffrey C., Terefenko, Eugene, Trybulski, Eugene, Berrodin, Thomas J., Cohen, Jeffrey, Winneker, Richard C., Yudt, Matthew R., Zhang, Zhiming, Zhu, Yuan, Zhang, Puwen
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Identification of novel estrogen receptor α antagonists
Shao, Dalei, Berrodin, Thomas J, Manas, Eric, Hauze, Diane, Powers, Robert, Bapat, Ashok, Gonder, Daniel, Winneker, Richard C, Frail, Donald E
Published in The Journal of steroid biochemistry and molecular biology (01.04.2004)
Published in The Journal of steroid biochemistry and molecular biology (01.04.2004)
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7-Aryl 1,5-dihydro-benzo[ e][1,4]oxazepin-2-ones and analogs as non-steroidal progesterone receptor antagonists
Zhang, Puwen, Kern, Jeffrey C., Terefenko, Eugene A., Fensome, Andrew, Unwalla, Ray, Zhang, Zhiming, Cohen, Jeffrey, Berrodin, Thomas J., Yudt, Matthew R., Winneker, Richard C., Wrobel, Jay
Published in Bioorganic & medicinal chemistry (01.07.2008)
Published in Bioorganic & medicinal chemistry (01.07.2008)
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1,5-Dihydro-benzo[ e][1,4]oxazepin-2( 1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators
Kern, Jeffrey C., Terefenko, Eugene A., Fensome, Andrew, Unwalla, Ray, Wrobel, Jay, Cohen, Jeffrey, Zhu, Yuan, Berrodin, Thomas J., Yudt, Matthew R., Winneker, Richard C., Zhang, Zhiming, Zhang, Puwen
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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Effect of Estrogen Agonists and Antagonists on Induction of Progesterone Receptor in a Rat Hypothalamic Cell Line
Fitzpatrick, Susan L, Berrodin, Thomas J, Jenkins, Susan F, Sindoni, Deborah M, Deecher, Darlene C, Frail, Donald E
Published in Endocrinology (Philadelphia) (01.09.1999)
Published in Endocrinology (Philadelphia) (01.09.1999)
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Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen
Mangatt, Biju, Pietra, Anthony D., Waszkiewicz, Anna, Jaworski, Jon-Paul, Ghidelli-Disse, Sonja, Berrodin, Thomas J., Sherk, Christian S., Meinhold, Derrick W., Rutkowska-Klute, Anna, Sundaram, Shanker K., Ganji, Gopinath, Halsey, Wendy S., Livi, George P., Li, William, Mack, James, Romeril, Stuart P., Minthorn, Elisabeth A., Kumar, Rakesh, Drewes, Gerard C., Heerding, Dirk A., Kallal, Lorena A., Buser, Carolyn A., Medina, Jesus R.
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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1-Methyl-1 H-pyrrole-2-carbonitrile containing tetrahydronaphthalene derivatives as non-steroidal progesterone receptor antagonists
Kern, Jeffrey C., Terefenko, Eugene, Trybulski, Eugene, Berrodin, Thomas J., Cohen, Jeffrey, Winneker, Richard C., Yudt, Matthew R., Zhang, Zhiming, Zhu, Yuan, Zhang, Puwen
Published in Bioorganic & medicinal chemistry letters (2010)
Published in Bioorganic & medicinal chemistry letters (2010)
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