Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist
Zhang, Minli, Zhou, Diansong, Wang, Yi, Maier, Donna L, Widzowski, Daniel V, Sobotka-Briner, Cynthia D, Brockel, Becky J, Potts, William M, Shenvi, Ashok B, Bernstein, Peter R, Pierson, M Edward
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
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Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Pharmacophore-Based Design of Phenyl-[hydroxycyclohexyl] Cycloalkyl-Carboxamide Mitofusin Activators with Improved Neuronal Activity
Dang, Xiawei, Williams, Sidney B, Devanathan, Sriram, Franco, Antonietta, Fu, Lijun, Bernstein, Peter R, Walters, Daniel, Dorn, Gerald W
Published in Journal of medicinal chemistry (09.09.2021)
Published in Journal of medicinal chemistry (09.09.2021)
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Correction to “Discovery of 6‑Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondrial Diseases”
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G, Devanathan, Sriram, Dolle, Roland E, Bernstein, Peter R, Dorn, Gerald W
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Discovery of a Potent and Selective PI3Kδ Inhibitor ( S )-2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl-4 H -quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Discovery of a Potent and Selective PI3Kδ Inhibitor (S)‑2,4-Diamino-6-((1-(7-fluoro-1-(4-fluorophenyl)-4-oxo-3-phenyl‑4H‑quinolizin-2-yl)ethyl)amino)pyrimidine-5-carbonitrile with Improved Pharmacokinetic Profile and Superior Efficacy in Hematological Cancer Models
Shukla, Manojkumar R, Patra, Sukanya, Verma, Mahip, Sadasivam, Gayathri, Jana, Nirmal, Mahangare, Sachin J, Vidhate, Prashant, Lagad, Dipak, Tarage, Anand, Cheemala, Murthy, Kulkarni, Chaitanya, Bhagwat, Shankar, Chaudhari, Vinod D, Sayyed, Majid, Pachpute, Vipul, Phadtare, Ramesh, Gole, Gopal, Phukan, Samiron, Sunkara, Brahmam, Samant, Charudatt, Shingare, Manisha, Naik, Aditya, Trivedi, Sneha, Marisetti, Ajit Kumar, Reddy, Madhusudhan, Gholve, Milind, Mahajan, Nilesh, Sabde, Sudeep, Patil, Vinod, Modi, Dipak, Mehta, Maneesh, Nigade, Prashant, Tamane, Kaustubh, Tota, Swati, Goyal, Hemant, Volam, Harish, Pawar, Shashikant, Ahirrao, Prajakta, Dinchhana, Lal, Mallurwar, Sadanand, Akarte, Atul, Bokare, Anand, Kanhere, Rupesh, Reddy, Neetinkumar, Koul, Sarita, Dandekar, Manoj, Singh, Minakshi, Bernstein, Peter R, Narasimham, Lakshmi, Bhonde, Mandar, Gundu, Jayasagar, Goel, Rajan, Kulkarni, Sanjeev, Sharma, Sharad, Kamboj, Rajender Kumar, Palle, Venkata P
Published in Journal of medicinal chemistry (10.12.2020)
Published in Journal of medicinal chemistry (10.12.2020)
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Discovery of isoquinolinone and naphthyridinone-based inhibitors of poly(ADP-ribose) polymerase-1 (PARP1) as anticancer agents: Structure activity relationship and preclinical characterization
Karche, Navnath P., Bhonde, Mandar, Sinha, Neelima, Jana, Gourhari, Kukreja, Gagan, Kurhade, Sanjay P., Jagdale, Arun R., Tilekar, Ajay R., Hajare, Anil K., Jadhav, Ganesh R., Gupta, Nishant R., Limaye, Rohan, Khedkar, Nilesh, Thube, Baban R., Shaikh, Javed S., Rao Irlapati, Nageswara, Phukan, Samiron, Gole, Gopal, Bommakanti, Apparao, Khanwalkar, Harshal, Pawar, Yogesh, Kale, Ramesh, Kumar, Rakesh, Gupta, Rajesh, Praveen Kumar, V.R., Wahid, Saif, Francis, Albi, Bhat, Tariq, Kamble, Nivrutti, Patil, Vinod, Nigade, Prashant B., Modi, Dipak, Pawar, Shashikant, Naidu, Sneha, Volam, Harish, Pagdala, Vamsi, Mallurwar, Sadanand, Goyal, Hemant, Bora, Pushpak, Ahirrao, Prajakta, Singh, Minakshi, Kamalakannan, Prabhakaran, Naik, Kumar Ram, Kumar, Pradipta, Powar, Rajendra G., Shankar, Rajesh B., Bernstein, Peter R., Gundu, Jayasagar, Nemmani, Kumar, Narasimham, Lakshmi, George, Kochumalayil Shaji, Sharma, Sharad, Bakhle, Dhananjay, Kamboj, Rajender Kumar, Palle, Venkata P.
Published in Bioorganic & medicinal chemistry (15.12.2020)
Published in Bioorganic & medicinal chemistry (15.12.2020)
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Design, Synthesis, and SAR of Tachykinin Antagonists: Modulation of Balance in NK1/NK2 Receptor Antagonist Activity
Albert, Jeffrey S, Aharony, David, Andisik, Donald, Barthlow, Herbert, Bernstein, Peter R, Bialecki, Russell A, Dedinas, Robert, Dembofsky, Bruce T, Hill, Daniel, Kirkland, Karin, Koether, Gerard M, Kosmider, Benedict J, Ohnmacht, Cyrus, Palmer, William, Potts, William, Rumsey, William, Shen, Lihong, Shenvi, Ashok, Sherwood, Scott, Warwick, Paul J, Russell, Keith
Published in Journal of medicinal chemistry (29.08.2002)
Published in Journal of medicinal chemistry (29.08.2002)
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Structural Analysis and Optimization of NK1 Receptor Antagonists through Modulation of Atropisomer Interconversion Properties
Albert, Jeffrey S, Ohnmacht, Cyrus, Bernstein, Peter R, Rumsey, William L, Aharony, David, Alelyunas, Yun, Russell, Daniel J, Potts, William, Sherwood, Scott A, Shen, Lihong, Dedinas, Robert F, Palmer, William E, Russell, Keith
Published in Journal of medicinal chemistry (29.01.2004)
Published in Journal of medicinal chemistry (29.01.2004)
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Naphtho[2,1-b][1,5] and [1,2-f][1,4]oxazocines as selective NK1 antagonists
OHNMACHT, Cyrus J, ALBERT, Jeffrey S, BERNSTEIN, Peter R, RUMSEY, William L, MASEK, Brian B, DEMBOFSKY, Bruce T, KOETHER, Gerard M, ANDISIK, Donald W, AHARONY, David
Published in Bioorganic & medicinal chemistry (15.05.2004)
Published in Bioorganic & medicinal chemistry (15.05.2004)
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Structural Consequences of the Addition of Lithium Halides in Enolization and Aldol Reactions
Henderson, Kenneth W, Dorigo, Andrea E, Liu, Qi-Yong, Williard, Paul G, Schleyer, Paul von Ragué, Bernstein, Peter R
Published in Journal of the American Chemical Society (14.02.1996)
Published in Journal of the American Chemical Society (14.02.1996)
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Discovery of Spirofused Piperazine and Diazepane Amides as Selective Histamine‑3 Antagonists with in Vivo Efficacy in a Mouse Model of Cognition
Brown, Dean G, Bernstein, Peter R, Griffin, Andrew, Wesolowski, Steve, Labrecque, Denis, Tremblay, Maxime C, Sylvester, Mark, Mauger, Russell, Edwards, Phillip D, Throner, Scott R, Folmer, James J, Cacciola, Joseph, Scott, Clay, Lazor, Lois A, Pourashraf, Mehrnaz, Santhakumar, Vijayaratnam, Potts, William M, Sydserff, Simon, Giguère, Pascall, Lévesque, Carine, Dasser, Mohammed, Groblewski, Thierry
Published in Journal of medicinal chemistry (13.02.2014)
Published in Journal of medicinal chemistry (13.02.2014)
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Discovery of novel, orally active dual NK1/NK2 antagonists
BERNSTEIN, Peter R, AHARONY, David, KOSMIDER, Benedict J, KIRKLAND, Karin, OHNMACHT, Cyrus J, POTTS, William, RUMSEY, William L, LIHONG SHEN, SHENVI, Ashok, SHERWOOD, Scott, STOLLMAN, David, RUSSELL, Keith, ALBERT, Jeffrey S, ANDISIK, Donald, BARTHLOW, Herbert G, BIALECKI, Russell, DAVENPORT, Timothy, DEDINAS, Robert F, DEMBOFSKY, Bruce T, KOETHER, Gerard
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
Published in Bioorganic & medicinal chemistry letters (22.10.2001)
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De Novo Design of a Picomolar Nonbasic 5-HT1B Receptor Antagonist
Nugiel, David A, Krumrine, Jennifer R, Hill, Daniel C, Damewood, James R, Bernstein, Peter R, Sobotka-Briner, Cynthia D, Liu, JianWei, Zacco, Anna, Pierson, M. Edward
Published in Journal of medicinal chemistry (25.02.2010)
Published in Journal of medicinal chemistry (25.02.2010)
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Azepines and Piperidines with Dual Norepinephrine Dopamine Uptake Inhibition and Antidepressant Activity
Brown, Dean G, Bernstein, Peter R, Wu, Ye, Urbanek, Rebecca A, Becker, Christopher W, Throner, Scott R, Dembofsky, Bruce T, Steelman, Gary B, Lazor, Lois A, Scott, Clay W, Wood, Michael W, Wesolowski, Steven S, Nugiel, David A, Koch, Stephanie, Yu, Jian, Pivonka, Donald E, Li, Shuang, Thompson, Carol, Zacco, Anna, Elmore, Charles S, Schroeder, Patricia, Liu, JianWei, Hurley, Christopher A, Ward, Stuart, Hunt, Hazel J, Williams, Karen, McLaughlin, Joseph, Hoesch, Valerie, Sydserff, Simon, Maier, Donna, Aharony, David
Published in ACS medicinal chemistry letters (10.01.2013)
Published in ACS medicinal chemistry letters (10.01.2013)
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Design and optimization of cyclized NK1 antagonists with controlled atropisomeric properties
Albert, JS, Ohnmacht, C, Bernstein, PR, Rumsey, WL, Aharony, D, Masek, BB, Dembofsky, BT, Koether, GM, Potts, W, Evenden, JL
Published in Tetrahedron (10.05.2004)
Published in Tetrahedron (10.05.2004)
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A novel series of selective leukotriene antagonists: exploration and optimization of the acidic region in 1,6-disubstituted indoles and indazoles
Yee, Ying K, Bernstein, Peter R, Adams, Edward J, Brown, Frederick J, Cronk, Laura A, Hebbel, Kevin C, Vacek, Edward P, Krell, Robert D, Snyder, David W
Published in Journal of medicinal chemistry (01.09.1990)
Published in Journal of medicinal chemistry (01.09.1990)
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Discovery of 6-Phenylhexanamide Derivatives as Potent Stereoselective Mitofusin Activators for the Treatment of Mitochondria! Diseases
Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Li, Jiajia, Rocha, Agostinho G., Devanathan, Sriram, Dolle, Roland E., Bernstein, Peter R., Dorn, Gerald W.
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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