Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release
Zuch de Zafra, Christina L, Fajardo, Flordeliza, Zhong, Wendy, Bernett, Matthew J, Muchhal, Umesh S, Moore, Gregory L, Stevens, Jennitte, Case, Ryan, Pearson, Joshua T, Liu, Siyuan, McElroy, Patricia L, Canon, Jude, Desjarlais, John R, Coxon, Angela, Balazs, Mercedesz, Nolan-Stevaux, Olivier
Published in Clinical cancer research (01.07.2019)
Published in Clinical cancer research (01.07.2019)
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IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion
Li, Ji, Clark, Robyn, Slaga, Dionysos, Avery, Kendra, Liu, Ke, Schubbert, Suzanne, Varma, Rajat, Chiang, Eugene, Totpal, Klara, Bernett, Matthew J, Holder, Patrick G, Junttila, Teemu T
Published in Molecular cancer therapeutics (04.09.2024)
Published in Molecular cancer therapeutics (04.09.2024)
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A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats
Moore, Gregory L., Bernett, Matthew J., Rashid, Rumana, Pong, Erik W., Nguyen, Duc-Hanh T., Jacinto, Jonathan, Eivazi, Araz, Nisthal, Alex, Diaz, Juan E., Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R.
Published in Methods (San Diego, Calif.) (01.02.2019)
Published in Methods (San Diego, Calif.) (01.02.2019)
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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer
Nolan-Stevaux, Olivier, Li, Cong, Liang, Lingming, Zhan, Jinghui, Estrada, Juan, Osgood, Tao, Li, Fei, Zhang, Hanzhi, Case, Ryan, Murawsky, Christopher M, Estes, Bram, Moore, Gregory L, Bernett, Matthew J, Muchhal, Umesh, Desjarlais, John R, Staley, Binnaz K, Stevens, Jennitte, Cooke, Keegan S, Aeffner, Famke, Thomas, Oliver, Stieglmaier, Julia, Lee, Jae-Lyun, Coxon, Angela, Bailis, Julie M
Published in Cancer discovery (12.01.2024)
Published in Cancer discovery (12.01.2024)
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Potent In vitro and In vivo Activity of an Fc-Engineered Anti-CD19 Monoclonal Antibody against Lymphoma and Leukemia
HORTON, Holly M, BERNETT, Matthew J, DESJARLAIS, John R, ZHUKOVSKY, Eugene A, PONG, Erik, PEIPP, Matthias, KARKI, Sher, CHU, Seung Y, RICHARDS, John O, VOSTIAR, Igor, JOYCE, Patrick F, REPP, Roland
Published in Cancer research (Chicago, Ill.) (01.10.2008)
Published in Cancer research (Chicago, Ill.) (01.10.2008)
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Reduction of total IgE by targeted coengagement of IgE B-cell receptor and FcγRIIb with Fc-engineered antibody
Chu, Seung Y., PhD, Horton, Holly M., PhD, Pong, Erik, MS, Leung, Irene W.L., PhD, Chen, Hsing, MS, Nguyen, Duc-Hanh, BS, Bautista, Cristina, BS, Muchhal, Umesh S., PhD, Bernett, Matthew J., PhD, Moore, Gregory L., PhD, Szymkowski, David E., PhD, Desjarlais, John R., PhD
Published in Journal of allergy and clinical immunology (01.04.2012)
Published in Journal of allergy and clinical immunology (01.04.2012)
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Translational PK/PD and the first-in-human dose selection of a PD1/IL15: an engineered recombinant targeted cytokine for cancer immunotherapy
Yadav, Rajbharan, Schubbert, Suzanne, Holder, Patrick G, Chiang, Eugene Y, Kiabi, Nargess, Bogaert, Liz, Leung, Irene, Rashid, Rumana, Avery, Kendra N, Bonzon, Christine, Desjarlais, John R, Sanjabi, Shomyseh, Sharma, Amy, Lepherd, Michelle, Shelton, Amy, Chan, Pam, Liu, Yanqiu, Joslyn, Louis, Hosseini, Iraj, Stefanich, Eric G, Kamath, Amrita V, Bernett, Matthew J, Shivva, Vittal
Published in Frontiers in pharmacology (03.06.2024)
Published in Frontiers in pharmacology (03.06.2024)
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Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematologic malignancies
Horton, Holly M., Bernett, Matthew J., Peipp, Matthias, Pong, Erik, Karki, Sher, Chu, Seung Y., Richards, John O., Chen, Hsing, Repp, Roland, Desjarlais, John R., Zhukovsky, Eugene A.
Published in Blood (21.10.2010)
Published in Blood (21.10.2010)
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Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function
Tai, Yu-Tzu, Horton, Holly M., Kong, Sun-Young, Pong, Erik, Chen, Hsing, Cemerski, Saso, Bernett, Matthew J., Nguyen, Duc-Hanh T., Karki, Sher, Chu, Seung Y., Lazar, Greg A., Munshi, Nikhil C., Desjarlais, John R., Anderson, Kenneth C., Muchhal, Umesh S.
Published in Blood (01.03.2012)
Published in Blood (01.03.2012)
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Dissecting strategies to tune the therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022
Atyeo, Caroline, Slein, Matthew D, Fischinger, Stephanie, Burke, John, Schäfer, Alexandra, Leist, Sarah R, Kuzmina, Natalia A, Mire, Chad, Honko, Anna, Johnson, Rebecca, Storm, Nadia, Bernett, Matthew, Tong, Pei, Zuo, Teng, Lin, Junrui, Zuiani, Adam, Linde, Caitlyn, Suscovich, Todd, Wesemann, Duane R, Griffiths, Anthony, Desjarlais, John R, Juelg, Boris D, Goudsmit, Jaap, Bukreyev, Alexander, Baric, Ralph, Alter, Galit
Published in JCI insight (11.01.2021)
Published in JCI insight (11.01.2021)
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Crystal Structure and Biochemical Characterization of Human Kallikrein 6 Reveals That a Trypsin-like Kallikrein Is Expressed in the Central Nervous System
Bernett, Matthew J., Blaber, Sachiko I., Scarisbrick, Isobel A., Dhanarajan, Pushparani, Thompson, Steven M., Blaber, Michael
Published in The Journal of biological chemistry (05.07.2002)
Published in The Journal of biological chemistry (05.07.2002)
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Abstract 5000: Immunotherapy with anti-PSMA x anti-CD3 bispecific antibody stimulates potent killing of a human prostate cancer cell line and target-mediated T cell activation in monkeys: A potential therapy for prostate cancer
Chu, Seung Y., Pong, Erik W. K., Rashid, Rumana, Chen, Hsing, Chan, Emily W., Phung, Sheryl, Endo, Nancy A., Ardila, Maria C., Bonzon, Christine, Leung, Irene W. L., Muchhal, Umesh S., Moore, Gregory L., Bernett, Matthew J., Desjarlais, John R., Szymkowski, David E.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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787 Natural killer cell engagers activate innate and adaptive immunity and show synergy with proinflammatory cytokines
Bykova, Katrina, Faber, Matthew, Liu, Ke, Siddiqi, Noor, Bernett, Matthew, Bonzon, Christine, Diaz, Juan, Nam, Dong Hyun, Avery, Kendra, Qi, Jing, Rashid, Rumana, Bahjat, Rena, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2021)
Published in Journal for immunotherapy of cancer (01.11.2021)
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Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions
Bernett, Matthew J., Karki, Sher, Moore, Gregory L., Leung, Irene W.L., Chen, Hsing, Pong, Erik, Nguyen, Duc-Hanh T., Jacinto, Jonathan, Zalevsky, Jonathan, Muchhal, Umesh S., Desjarlais, John R., Lazar, Greg A.
Published in Journal of molecular biology (12.03.2010)
Published in Journal of molecular biology (12.03.2010)
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564 Potency-reduced and extended half-life IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity with potentially improved therapeutic index compared to native IL12 agents
Bernett, Matthew, Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung, Muchhal, Umesh, Desjarlais, John
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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Abstract 5549: Potency-reduced IL12 heterodimeric Fc-fusions exhibit strong anti-tumor activity
Varma, Rajat, Liu, Ke, Bonzon, Christine, Rashid, Rumana, Rodriguez, Nicole, Hassanzadeh-Kiabi, Nargess, Ardila, Connie, Chu, Seung Y., Muchhal, Umesh S., Desjarlais, John R., Bernett, Matthew J.
Published in Cancer research (Chicago, Ill.) (15.08.2020)
Published in Cancer research (Chicago, Ill.) (15.08.2020)
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Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn
Bernett, Matthew J., Chu, Seung Y., Leung, Irene, Moore, Gregory L., Lee, Sung-Hyung, Pong, Erik, Chen, Hsing, Phung, Sheryl, Muchhal, Umesh S., Horton, Holly M., Lazar, Greg A., Desjarlais, John R, Szymkowski, David E.
Published in mAbs (01.05.2013)
Published in mAbs (01.05.2013)
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1.70 Å X-ray structure of human apo kallikrein 1: Structural changes upon peptide inhibitor/substrate binding
Laxmikanthan, Gurunathan, Blaber, Sachiko I., Bernett, Matthew J., Scarisbrick, Isobel A., Juliano, Maria Aparecida, Blaber, Michael
Published in Proteins, structure, function, and bioinformatics (01.03.2005)
Published in Proteins, structure, function, and bioinformatics (01.03.2005)
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718 AMG 509, a STEAP1 x CD3 bispecific XmAb® 2+1 immune therapy, exhibits avidity-driven binding and preferential killing of high STEAP1-expressing prostate and Ewing sarcoma cancer cells
Li, Cong, Fort, Madeline, Liang, Lingming, Moore, Gregory, Bernett, Matthew, Muchhal, Umesh, Osgood, Tao, Yabut, Rodolfo, Kaliyaperumal, Sarav, Harrold, John, Canon, Jude, Rogojina, Anna, Kurmasheva, Raushan, Desjarlais, John, Houghton, Peter, Nolan-Stevaux, Olivier
Published in Journal for immunotherapy of cancer (01.11.2020)
Published in Journal for immunotherapy of cancer (01.11.2020)
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