Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase
Gentles, Robert G., Ding, Min, Bender, John A., Bergstrom, Carl P., Grant-Young, Katharine, Hewawasam, Piyasena, Hudyma, Thomas, Martin, Scott, Nickel, Andrew, Regueiro-Ren, Alicia, Tu, Yong, Yang, Zhong, Yeung, Kap-Sun, Zheng, Xiaofan, Chao, Sam, Sun, Jung-Hui, Beno, Brett R., Camac, Daniel M., Chang, Chong-Hwan, Gao, Mian, Morin, Paul E., Sheriff, Steven, Tredup, Jeff, Wan, John, Witmer, Mark R., Xie, Dianlin, Hanumegowda, Umesh, Knipe, Jay, Mosure, Kathy, Santone, Kenneth S., Parker, Dawn D., Zhuo, Xiaoliang, Lemm, Julie, Liu, Mengping, Pelosi, Lenore, Rigat, Karen, Voss, Stacey, Wang, Yi, Wang, Ying-Kai, Colonno, Richard J., Gao, Min, Roberts, Susan B., Gao, Qi, Ng, Alicia, Meanwell, Nicholas A, Kadow, John F.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Journal Article
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor
Gillman, Kevin W, Starrett, John E, Parker, Michael F, Xie, Kai, Bronson, Joanne J, Marcin, Lawrence R, McElhone, Kate E, Bergstrom, Carl P, Mate, Robert A, Williams, Richard, Meredith, Jere E, Burton, Catherine R, Barten, Donna M, Toyn, Jeremy H, Roberts, Susan B, Lentz, Kimberley A, Houston, John G, Zaczek, Robert, Albright, Charles F, Decicco, Carl P, Macor, John E, Olson, Richard E
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Journal Article
The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression
Burton, Catherine R., Meredith, Jere E., Barten, Donna M., Goldstein, Margi E., Krause, Carol M., Kieras, Cathy J., Sisk, Lisa, Iben, Lawrence G., Polson, Craig, Thompson, Mark W., Lin, Xu-Alan, Corsa, Jason, Fiedler, Tracey, Pierdomenico, Maria, Cao, Yang, Roach, Arthur H., Cantone, Joseph L., Ford, Michael J., Drexler, Dieter M., Olson, Richard E., Yang, Michael G., Bergstrom, Carl P., McElhone, Kate E., Bronson, Joanne J., Macor, John E., Blat, Yuval, Grafstrom, Robert H., Stern, Andrew M., Seiffert, Dietmar A., Zaczek, Robert, Albright, Charles F., Toyn, Jeremy H.
Published in The Journal of biological chemistry (22.08.2008)
Published in The Journal of biological chemistry (22.08.2008)
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Journal Article
2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as γ-secretase inhibitors
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Dee, Michael F., Gai, Yonghua, Guss, Valerie L., Higgins, Mendi A., Keavy, Daniel J., Loo, Alice, Mate, Robert A., Marcin, Larry R., McElhone, Katharine E., Polson, Craig T., Roberts, Susan B., Macor, John E.
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
Published in Bioorganic & medicinal chemistry letters (15.11.2012)
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Journal Article
Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase
Bergstrom, Carl P., Sloan, Charles P., Lau, Wai-Yu, Smith, David W., Zheng, Ming, Hansel, Steven B., Polson, Craig T., Corsa, Jason A., Barten, Donna M., Felsenstein, Kevin M., Roberts, Susan B.
Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Journal Article
N-(5-Chloro-2-(hydroxymethyl)-N-alkyl-arylsulfonamides as γ-secretase inhibitors
Parker, Michael F., Barten, Donna M., Bergstrom, Carl P., Bronson, Joanne J., Corsa, Jason A., Deshpande, Milind S., Felsenstein, Kevin M., Guss, Valerie L., Hansel, Steven B., Johnson, Graham, Keavy, Daniel J., Lau, Wai Y., Mock, Jeremy, Prasad, C.V.C., Polson, Craig T., Sloan, Charles P., Smith, David W., Wallace, Owen B., Wang, Henry H., Williams, Andrew, Zheng, Ming
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
Published in Bioorganic & medicinal chemistry letters (15.08.2007)
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Journal Article
Nitrogen-appended N-alkylsulfonamides as inhibitors of γ-secretase
Bergstrom, Carl P., Sloan, Charles P., Wang, Henry H., Parker, Michael F., Smith, David W., Zheng, Ming, Hansel, Steven B., Polson, Craig T., Barber, Lauren E., Bursuker, Isia, Guss, Valerie L., Corsa, Jason A., Barten, Donna M., Felsenstein, Kevin M., Roberts, Susan B.
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
7H-INDOLO[2,1-A] [2] BENZAZEPINE-10-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT OF HEPATITIS C
BERGSTROM CARL P, DING MIN, MARTIN SCOTT W, ZHENG XIAOFAN, GENTLES ROBERT G
Year of Publication 16.02.2011
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Year of Publication 16.02.2011
Patent
Characterization of Hamster Recombinant Monomorphic and Polymorphic Arylamine N-Acetyltransferases : Bioactivation and Mechanism-based Inactivation Studies with n-hydroxy-2-acetylaminofluorene
Sticha, Kristina R.K, Bergstrom, Carl P, Wagner, Carston R, Hanna, Patrick E
Published in Biochemical pharmacology (01.07.1998)
Published in Biochemical pharmacology (01.07.1998)
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Journal Article
Nmr Studies of Dimeric 2,3-Dihydroxy-N-benzoyl Serine
Bergstrom, Carl P, Lu, Matthias C, Bell, Charles L
Published in Journal of natural products (Washington, D.C.) (01.07.1991)
Published in Journal of natural products (Washington, D.C.) (01.07.1991)
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Journal Article
The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression
Catherine R. Burton, Jere E. Meredith, Donna M. Barten, Margi E. Goldstein, Carol M. Krause, Cathy J. Kieras, Lisa Sisk, Lawrence G. Iben, Craig Polson, Mark W. Thompson, Xu-Alan Lin, Jason Corsa, Tracey Fiedler, Maria Pierdomenico, Yang Cao, Arthur H. Roach, Joseph L. Cantone, Michael J. Ford, Dieter M. Drexler, Richard E. Olson, Michael G. Yang, Carl P. Bergstrom, Kate E. McElhone, Joanne J. Bronson, John E. Macor, Yuval Blat, Robert H. Grafstrom, Andrew M. Stern, Dietmar A. Seiffert, Robert Zaczek, Charles F. Albright, Jeremy H. Toyn
Published in The Journal of biological chemistry (22.08.2008)
Published in The Journal of biological chemistry (22.08.2008)
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Journal Article
N -5 -Chloro -2-(hydroxymethyl)-N -alkyl -arylsulfonamides as γ-secretase inhibitors
PARKER, Michael F, BARTEN, Donna M, KEAVY, Daniel J, LAU, Wai Y, MOCK, Jeremy, PRASAD, C. V. C, POISON, Craig T, SLOAN, Charles P, SMITH, David W, WALLACE, Owen B, WANG, Henry H, WILLIAMS, Andrew, BERGSTROM, Carl P, MING ZHENG, BRONSON, Joanne J, CORSA, Jason A, DESHPANDE, Milind S, FELSENSTEIN, Kevin M, GUSS, Valerie L, HANSEL, Steven B, JOHNSON, Graham
Published in Bioorganic & medicinal chemistry letters (2007)
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Published in Bioorganic & medicinal chemistry letters (2007)
Journal Article
derivado de ácido 7h-indolo{2,1-a]{2]-benzapina-10-carboxílico para o tratamento de hepatite c
Min Ding, Scott W. Martin, Robert G. Gentles, Carl P. Bergstrom, Xiaofan Zheng
Year of Publication 24.09.2019
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Year of Publication 24.09.2019
Patent