Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity
Wang, Xiaolun, Berger, Dan M, Salaski, Edward J, Torres, Nancy, Dutia, Minu, Hanna, Cilien, Hu, Yongbo, Levin, Jeremy I, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen, Lucas, Judy
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Journal Article
Discovery and optimization of 7-aminofuro[2,3-c]pyridine inhibitors of TAK1
Hornberger, Keith R., Berger, Dan M., Crew, Andrew P., Dong, Hanqing, Kleinberg, Andrew, Li, An-Hu, Medeiros, Matthew R., Mulvihill, Mark J., Siu, Kam, Tarrant, James, Wang, Jing, Weng, Felix, Wilde, Victoria L., Albertella, Mark, Bittner, Mark, Cooke, Andrew, Gray, Michael J., Maresca, Paul, May, Earl, Meyn, Peter, Peick, William, Romashko, Darlene, Tanowitz, Michael, Tokar, Brianna
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
Published in Bioorganic & medicinal chemistry letters (15.08.2013)
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Journal Article
Discovery of highly potent and selective type I B-Raf kinase inhibitors
Wang, Xiaolun, Berger, Dan M., Salaski, Edward J., Torres, Nancy, Hu, Yongbo, Levin, Jeremy I., Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Journal Article
Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors
Wang, Xiaolun, Salaski, Edward J., Berger, Dan M., Powell, Dennis, Hu, Yongbo, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
Published in Bioorganic & medicinal chemistry letters (01.12.2011)
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Journal Article
Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
Miller, Lori M., Mayer, Scott C., Berger, Dan M., Boschelli, Diane H., Boschelli, Frank, Di, Li, Du, Xuemei, Dutia, Minu, Floyd, Middleton B., Johnson, Mark, Kenny, Cynthia Hess, Krishnamurthy, Girija, Moy, Franklin, Petusky, Susan, Tkach, Diane, Torres, Nancy, Wu, Biqi, Xu, Weixin
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors
Berger, Dan M., Torres, Nancy, Dutia, Minu, Powell, Dennis, Ciszewski, Greg, Gopalsamy, Ariamala, Levin, Jeremy I., Kim, Kyung-Hee, Xu, Weixin, Wilhelm, James, Hu, YongBo, Collins, Karen, Feldberg, Larry, Kim, Steven, Frommer, Eileen, Wojciechowicz, Donald, Mallon, Robert
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Journal Article
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors
Di Grandi, Martin J., Berger, Dan M., Hopper, Darrin W., Zhang, Chunchun, Dutia, Minu, Dunnick, Alejandro L., Torres, Nancy, Levin, Jeremy I., Diamantidis, George, Zapf, Christoph W., Bloom, Jonathan D., Hu, YongBo, Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors
Berger, Dan M., Dutia, Minu, Powell, Dennis, Floyd, Middleton B., Torres, Nancy, Mallon, Robert, Wojciechowicz, Donald, Kim, Steven, Feldberg, Larry, Collins, Karen, Chaudhary, Inder
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Journal Article
Synthesis and biological evaluation of tricyclic anilinopyrimidines as IKKβ inhibitors
Crombie, Aimee L., Sum, Fuk-Wah, Powell, Dennis W., Hopper, Darrin W., Torres, Nancy, Berger, Dan M., Zhang, Yixian, Gavriil, Maria, Sadler, Tammy M., Arndt, Kim
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
Published in Bioorganic & medicinal chemistry letters (15.06.2010)
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Journal Article
4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile Inhibitors of Epidermal Growth Factor Receptor Kinase and Their Bioisosteric Relationship to the 4-Anilino-6,7-dialkoxyquinazoline Inhibitors
Wissner, Allan, Berger, Dan M, Boschelli, Diane H, Floyd, M. Brawner, Greenberger, Lee M, Gruber, Brian C, Johnson, Bernard D, Mamuya, Nellie, Nilakantan, Ramaswamy, Reich, Marvin F, Shen, Ru, Tsou, Hwei-Ru, Upeslacis, Erik, Wang, Yu Fen, Wu, Biqi, Ye, Fei, Zhang, Nan
Published in Journal of medicinal chemistry (24.08.2000)
Published in Journal of medicinal chemistry (24.08.2000)
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Journal Article
4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors
Berger, Dan M, Dutia, Minu, Birnberg, Gary, Powell, Dennis, Boschelli, Diane H, Wang, Yanong D, Ravi, Malini, Yaczko, Deanna, Golas, Jennifer, Lucas, Judy, Boschelli, Frank
Published in Journal of medicinal chemistry (22.09.2005)
Published in Journal of medicinal chemistry (22.09.2005)
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Journal Article
Carbon-14 labelling of 3-cyanoquinolines
Olszewski, John D., Berger, Dan M., May, Michael K.
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2007)
Published in Journal of labelled compounds & radiopharmaceuticals (01.04.2007)
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Journal Article
Conference Proceeding
Observation of differential reactivity of cyclic amines in SN2 and SNAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors
Hopper, Darrin W., Dutia, Minu, Berger, Dan M., Powell, Dennis W.
Published in Tetrahedron letters (01.01.2008)
Published in Tetrahedron letters (01.01.2008)
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Journal Article
Observation of differential reactivity of cyclic amines in S(N)2 and SNAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors
Hopper, Darrin W., Dutia, Minu, Berger, Dan M., Powell, Dennis W.
Published in Tetrahedron letters (01.01.2008)
Published in Tetrahedron letters (01.01.2008)
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Journal Article
Abstract A85: Discovery of highly potent and selective B-Raf Kinase inhibitors
Wang, Xiaolun, Berger, Dan M., Salaski, Edward J., Torres, Nancy, Hu, Yongbo, Jeremy, Levin I., Powell, Dennis, Wojciechowicz, Donald, Collins, Karen, Frommer, Eileen
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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Journal Article
Observation of differential reactivity of cyclic amines in S N2 and S NAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors
Hopper, Darrin W., Dutia, Minu, Berger, Dan M., Powell, Dennis W.
Published in Tetrahedron letters (2008)
Published in Tetrahedron letters (2008)
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Journal Article
4-Anilino-7-alkenylquinoIine-3-carbonitriles as potent MEI1 kinase inhibitors
BERGER, Dan M, DUTIA, Minu, CHAUDHARY, Inder, POWELL, Dennis, FLOYD, Middleton B, TORRES, Nancy, MALLON, Robert, WOJCIECHOWICZ, Donald, KIM, Steven, FELDBERG, Larry, COLLINS, Karen
Published in Bioorganic & medicinal chemistry (2008)
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Published in Bioorganic & medicinal chemistry (2008)
Journal Article