An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
Soucy, Teresa A., Smith, Peter G., Milhollen, Michael A., Berger, Allison J., Gavin, James M., Adhikari, Sharmila, Brownell, James E., Burke, Kristine E., Cardin, David P., Critchley, Stephen, Cullis, Courtney A., Doucette, Amanda, Garnsey, James J., Gaulin, Jeffrey L., Gershman, Rachel E., Lublinsky, Anna R., McDonald, Alice, Mizutani, Hirotake, Narayanan, Usha, Olhava, Edward J., Peluso, Stephane, Rezaei, Mansoureh, Sintchak, Michael D., Talreja, Tina, Thomas, Michael P., Traore, Tary, Vyskocil, Stepan, Weatherhead, Gabriel S., Yu, Jie, Zhang, Julie, Dick, Lawrence R., Claiborne, Christopher F., Rolfe, Mark, Bolen, Joseph B., Langston, Steven P.
Published in Nature (09.04.2009)
Published in Nature (09.04.2009)
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Journal Article
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
Tian, Ze, Zhao, Jian-jun, Tai, Yu-Tzu, Amin, Samir B., Hu, Yiguo, Berger, Allison J., Richardson, Paul, Chauhan, Dharminder, Anderson, Kenneth C.
Published in Blood (08.11.2012)
Published in Blood (08.11.2012)
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Journal Article
Preclinical Activity of the Oral Proteasome Inhibitor MLN9708 in Myeloma Bone Disease
GARCIA-GOMEZ, Antonio, QUWAIDER, Dalia, GROEN, Richard W. J, MATEO-URDIALES, Joaquin, FRAILE, Susana, GALARRAGA, Miguel, CHAUHAN, Dharminder, SAN MIGUEL, Jesús F, RAJE, Noopur, GARAYOA, Mercedes, CANAVESE, Miriam, OCIO, Enrique M, ZE TIAN, BLANCO, Juan F, BERGER, Allison J, ORTIZ-DE-SOLORZANO, Carlos, HERNANDEZ-IGLESIAS, Teresa, MARTENS, Anton C. M
Published in Clinical cancer research (15.03.2014)
Published in Clinical cancer research (15.03.2014)
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Journal Article
Antitumor Activity of the Investigational Proteasome Inhibitor MLN9708 in Mouse Models of B-cell and Plasma Cell Malignancies
LEE, Edmund C, FITZGERALD, Michael, PICKARD, Michael, ZHI LI, TAYBER, Olga, PING LI, HALES, Paul, CARSILLO, Mary, NEPPALLI, Vishala T, BERGER, Allison J, KUPPERMAN, Erik, MANFREDI, Mark, BANNERMAN, Bret, BOLEN, Joseph B, NESS, Brian Van, JANZ, Siegfried, DONELAN, Jill, BANO, Kristen, TERKELSEN, Jennifer, BRADLEY, Daniel P, SUBAKAN, Ozlem, SILVA, Matthew D, LIU, Ray
Published in Clinical cancer research (01.12.2011)
Published in Clinical cancer research (01.12.2011)
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Journal Article
KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism
Chattopadhyay, Nibedita, Berger, Allison J, Koenig, Erik, Bannerman, Bret, Garnsey, James, Bernard, Hugues, Hales, Paul, Maldonado Lopez, Angel, Yang, Yu, Donelan, Jill, Jordan, Kristen, Tirrell, Stephen, Stringer, Bradley, Xia, Cindy, Hather, Greg, Galvin, Katherine, Manfredi, Mark, Rhodes, Nelson, Amidon, Ben
Published in PloS one (28.12.2015)
Published in PloS one (28.12.2015)
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Journal Article
The discovery of a reciprocal relationship between tyrosine-kinase signaling and cullin neddylation
Friend, Samantha F, Peterson, Lisa K, Treacy, Eric, Stefanski, Adrianne L, Sosinowski, Tomasz, Pennock, Nathan D, Berger, Allison J, Winn, Virginia D, Dragone, Leonard L
Published in PloS one (04.10.2013)
Published in PloS one (04.10.2013)
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Journal Article
Phase I Study of the Novel Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (MLN4924) in Patients with Relapsed/Refractory Multiple Myeloma or Lymphoma
Shah, Jatin J, Jakubowiak, Andrzej J, O'Connor, Owen A, Orlowski, Robert Z, Harvey, R Donald, Smith, Mitchell R, Lebovic, Daniel, Diefenbach, Catherine, Kelly, Kevin, Hua, Zhaowei, Berger, Allison J, Mulligan, George, Faessel, Hélène M, Tirrell, Stephen, Dezube, Bruce J, Lonial, Sagar
Published in Clinical cancer research (01.01.2016)
Published in Clinical cancer research (01.01.2016)
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Journal Article
Phase I Study of the Investigational NEDD8-Activating Enzyme Inhibitor Pevonedistat (TAK-924/MLN4924) in Patients with Advanced Solid Tumors
Sarantopoulos, John, Shapiro, Geoffrey I, Cohen, Roger B, Clark, Jeffrey W, Kauh, John S, Weiss, Glen J, Cleary, James M, Mahalingam, Devalingam, Pickard, Michael D, Faessel, Hélène M, Berger, Allison J, Burke, Kristine, Mulligan, George, Dezube, Bruce J, Harvey, R Donald
Published in Clinical cancer research (15.02.2016)
Published in Clinical cancer research (15.02.2016)
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Journal Article
Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
Erdem, Suna, Lee, Hyojae James, Shankara Narayanan, Jayanth Surya Narayanan, Tharuka, Mohottige Don Neranjan, De la Torre, Jorge, Ren, Tianchen, Kuang, Yixuan, Abeywardana, Tharindumala, Li, Kevin, Berger, Allison J., Lowy, Andrew M., White, Rebekah R., Chen, Yuan
Published in Molecular cancer therapeutics (04.11.2024)
Published in Molecular cancer therapeutics (04.11.2024)
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Journal Article
T Cell-intrinsic Immunomodulatory Effects of TAK-981 (Subasumstat), a SUMO-activating Enzyme Inhibitor, in Chronic Lymphocytic Leukemia
Lam, Vi, Roleder, Carly, Liu, Tingting, Bruss, Nur, Best, Scott, Wang, Xiaoguang, Phillips, Tycel, Shouse, Geoffrey, Berger, Allison J, Alinari, Lapo, Wang, Lili, Siddiqi, Tanya, Pennock, Nathan D, Danilov, Alexey V
Published in Molecular cancer therapeutics (05.09.2023)
Published in Molecular cancer therapeutics (05.09.2023)
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Journal Article
The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR
Zhou, Liang, Chen, Shuang, Zhang, Yu, Kmieciak, Maciej, Leng, Yun, Li, Lihong, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Rahmani, Mohamed, Povirk, Lawrence, Chalasani, Sri, Berger, Allison J., Dai, Yun, Grant, Steven
Published in Blood (05.05.2016)
Published in Blood (05.05.2016)
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Journal Article
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924
Jazaeri, Amir A, Shibata, Etsuko, Park, Jonghoon, Bryant, Jennifer L, Conaway, Mark R, Modesitt, Susan C, Smith, Peter G, Milhollen, Michael A, Berger, Allison J, Dutta, Anindya
Published in Molecular cancer therapeutics (01.10.2013)
Published in Molecular cancer therapeutics (01.10.2013)
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Journal Article
Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies
Smith, David C., Kalebic, Thea, Infante, Jeffrey R., Siu, Lillian L., Sullivan, Daniel, Vlahovic, Gordana, Kauh, John S., Gao, Feng, Berger, Allison J., Tirrell, Stephen, Gupta, Neeraj, Di Bacco, Alessandra, Berg, Deborah, Liu, Guohui, Lin, Jianchang, Hui, Ai-Min, Thompson, John A.
Published in Investigational new drugs (01.06.2015)
Published in Investigational new drugs (01.06.2015)
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Journal Article
Abstract 3719: TAK-243, a small molecule inhibitor of the ubiquitin activating enzyme (UAE), disrupts DNA damage repair and sensitizes tumor cells and xenografts to ionizing radiation
Milhollen, Michael A., Shi, Judy Qiuju, Traore, Tary, Huck, Jessica, Sappal, Darshan, Iwai, Kenichi, Ohashi, Akihiro, Rabino, Claudia, Duffy, Jennifer A., Lightcap, Eric, Ishii, Yuko, Ciavarri, Jeffrey, Bence, Neil, Berger, Allison J., Hyer, Marc L.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Regulation of T cell receptor complex-mediated signaling by ubiquitin and ubiquitin-like modifications
Friend, Samantha F, Deason-Towne, Francina, Peterson, Lisa K, Berger, Allison J, Dragone, Leonard L
Published in American journal of clinical and experimental immunology (01.01.2014)
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Published in American journal of clinical and experimental immunology (01.01.2014)
Journal Article
Insulin-Like Growth Factor-Binding Protein 3 Expression Increases during Immortalization of Cervical Keratinocytes by Human Papillomavirus Type 16 E6 and E7 Proteins
Berger, Allison J., Baege, Astrid, Guillemette, Tracy, Deeds, James, Meyer, Ron, Disbrow, Gary, Schlegel, Richard, Schlegel, Robert
Published in The American journal of pathology (01.08.2002)
Published in The American journal of pathology (01.08.2002)
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Journal Article
Nedd8-Activating Enzyme Inhibition Enhances Anti-Tumor Immunity and PD1 Blockade in In Vivo lymphoma Models
Wang, Xiaoguang, Lam, Vi, Vuong, Dan, Liu, Tingting, Danilova, Olga, Siddiqi, Tanya, Berger, Allison J, Wang, Lili, Danilov, Alexey V.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-κB–dependent lymphoma
Milhollen, Michael A., Traore, Tary, Adams-Duffy, Jennifer, Thomas, Michael P., Berger, Allison J., Dang, Lenny, Dick, Lawrence R., Garnsey, James J., Koenig, Erik, Langston, Steven P., Manfredi, Mark, Narayanan, Usha, Rolfe, Mark, Staudt, Louis M., Soucy, Teresa A., Yu, Jie, Zhang, Julie, Bolen, Joseph B., Smith, Peter G.
Published in Blood (02.09.2010)
Published in Blood (02.09.2010)
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