The PROTACtable genome
Schneider, Melanie, Radoux, Chris J, Hercules, Andrew, Ochoa, David, Dunham, Ian, Zalmas, Lykourgos-Panagiotis, Hessler, Gerhard, Ruf, Sven, Shanmugasundaram, Veerabahu, Hann, Michael M, Thomas, Pam J, Queisser, Markus A, Benowitz, Andrew B, Brown, Kris, Leach, Andrew R
Published in Nature reviews. Drug discovery (01.10.2021)
Published in Nature reviews. Drug discovery (01.10.2021)
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Journal Article
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs
Anderson, Niall A., Cryan, Jenni, Ahmed, Adil, Dai, Han, McGonagle, Grant A., Rozier, Christine, Benowitz, Andrew B.
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
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Journal Article
The therapeutic potential of PROTACs
Benowitz, Andrew B, Jones, Katherine L, Harling, John D
Published in Expert opinion on therapeutic patents (2021)
Published in Expert opinion on therapeutic patents (2021)
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Journal Article
Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs
Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.
Published in Angewandte Chemie International Edition (18.10.2021)
Published in Angewandte Chemie International Edition (18.10.2021)
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Journal Article
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
Gilmartin, Aidan G, Groy, Arthur, Gore, Elizabeth R, Atkins, Charity, Long, Edward R, Montoute, Monica N, Wu, Zining, Halsey, Wendy, McNulty, Dean E, Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa, Kruger, Ryan G, McCabe, Michael T, Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B
Published in Haematologica (Roma) (01.07.2021)
Published in Haematologica (Roma) (01.07.2021)
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Journal Article
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL
Chung, Chun-wa, Dai, Han, Fernandez, Esther, Tinworth, Christopher P, Churcher, Ian, Cryan, Jenni, Denyer, Jane, Harling, John D, Konopacka, Agnieszka, Queisser, Markus A, Tame, Christopher J, Watt, Gillian, Jiang, Fan, Qian, Dongming, Benowitz, Andrew B
Published in ACS chemical biology (18.09.2020)
Published in ACS chemical biology (18.09.2020)
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Journal Article
Challenges and opportunities for in vivo PROTAC delivery
Benowitz, Andrew B, Scott-Stevens, Paul T, Harling, John D
Published in Future medicinal chemistry (01.01.2022)
Published in Future medicinal chemistry (01.01.2022)
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Journal Article
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
Mares, Alina, Miah, Afjal H, Smith, Ian E D, Rackham, Mark, Thawani, Aditya R, Cryan, Jenni, Haile, Pamela A, Votta, Bartholomew J, Beal, Allison M, Capriotti, Carol, Reilly, Michael A, Fisher, Don T, Zinn, Nico, Bantscheff, Marcus, MacDonald, Thomas T, Vossenkamper, Anna, Dace, Phoebe, Churcher, Ian, Benowitz, Andrew B, Watt, Gillian, Denyer, Jane, Scott-Stevens, Paul, Harling, John D
Published in Communications biology (20.03.2020)
Published in Communications biology (20.03.2020)
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Journal Article
A hit deconstruction approach for the discovery of fetal hemoglobin inducers
Benowitz, Andrew B., Eberl, H. Christian, Erickson-Miller, Connie L., Gilmartin, Aidan G., Gore, Elizabeth R., Montoute, Monica N., Wu, Zining
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Journal Article
Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays
Zeng, Xin, Kirkpatrick, Robert, Hofmann, Glenn, Grillot, Didier, Linhart, Valerie, Viviani, Fabrice, Marino, Jr, Joseph, Boyer, Joseph, Graham, Taylor L, Lu, Quinn, Wu, Zining, Benowitz, Andrew, Cousins, Rick
Published in PloS one (12.12.2018)
Published in PloS one (12.12.2018)
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Journal Article
Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase
Concha, Nestor, Huang, Jianzhong, Bai, Xiaopeng, Benowitz, Andrew, Brady, Pat, Grady, LaShadric C, Kryn, Luz Helena, Holmes, David, Ingraham, Karen, Jin, Qi, Pothier Kaushansky, Laura, McCloskey, Lynn, Messer, Jeffrey A, O’Keefe, Heather, Patel, Amish, Satz, Alexander L, Sinnamon, Robert H, Schneck, Jessica, Skinner, Steve R, Summerfield, Jennifer, Taylor, Amy, Taylor, J. David, Evindar, Ghotas, Stavenger, Robert A
Published in Journal of medicinal chemistry (11.08.2016)
Published in Journal of medicinal chemistry (11.08.2016)
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Journal Article
Total synthesis of mycolactones A and B
Song, Fengbin, Fidanze, Steve, Benowitz, Andrew B., Kishi, Yoshito
Published in Tetrahedron (25.06.2007)
Published in Tetrahedron (25.06.2007)
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Journal Article
A Phenotypic Approach for the Identification of New Molecules for Targeted Protein Degradation Applications
Stacey, Peter, Lithgow, Hannah, Lewell, Xiao, Konopacka, Agnieszka, Besley, Stephen, Green, Georgina, Whatling, Ryan, Law, Robert, Röth, Sascha, Sapkota, Gopal P., Smith, Ian E.D., Burley, Glenn A., Harling, John, Benowitz, Andrew B., Queisser, Markus A., Muelbaier, Marcel
Published in SLAS discovery (01.08.2021)
Published in SLAS discovery (01.08.2021)
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Journal Article
Discovery and Characterisation of Highly Cooperative FAK‐Degrading PROTACs
Law, Robert P., Nunes, Joao, Chung, Chun‐wa, Bantscheff, Marcus, Buda, Karol, Dai, Han, Evans, John P., Flinders, Adam, Klimaszewska, Diana, Lewis, Antonia J., Muelbaier, Marcel, Scott‐Stevens, Paul, Stacey, Peter, Tame, Christopher J., Watt, Gillian F., Zinn, Nico, Queisser, Markus A., Harling, John D., Benowitz, Andrew B.
Published in Angewandte Chemie (18.10.2021)
Published in Angewandte Chemie (18.10.2021)
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Journal Article
Fragment-Based Discovery of 6‑Azaindazoles As Inhibitors of Bacterial DNA Ligase
Howard, Steven, Amin, Nader, Benowitz, Andrew B, Chiarparin, Elisabetta, Cui, Haifeng, Deng, Xiaodong, Heightman, Tom D, Holmes, David J, Hopkins, Anna, Huang, Jianzhong, Jin, Qi, Kreatsoulas, Constantine, Martin, Agnes C. L, Massey, Frances, McCloskey, Lynn, Mortenson, Paul N, Pathuri, Puja, Tisi, Dominic, Williams, Pamela A
Published in ACS medicinal chemistry letters (12.12.2013)
Published in ACS medicinal chemistry letters (12.12.2013)
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Journal Article
Stereochemistry of the Core Structure of the Mycolactones
Benowitz, Andrew B, Fidanze, Steve, Small, P. L. C, Kishi, Yoshito
Published in Journal of the American Chemical Society (30.05.2001)
Published in Journal of the American Chemical Society (30.05.2001)
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Journal Article
Total Synthesis of the Mycolactones
Song, Fengbin, Fidanze, Steve, Benowitz, Andrew B, Kishi, Yoshito
Published in Organic letters (21.02.2002)
Published in Organic letters (21.02.2002)
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Journal Article
Design and Synthesis of a Competent Pyrrolinone−Peptide Hybrid Ligand for the Class II Major Histocompatibility Complex Protein HLA-DR1
Smith, Amos B, Benowitz, Andrew B, Sprengeler, Paul A, Barbosa, Joseph, Guzman, Mark C, Hirschmann, Ralph, Schweiger, Edwin J, Bolin, David R, Nagy, Zoltan, Campbell, Robert M, Cox, Donald C, Olson, Gary L
Published in Journal of the American Chemical Society (13.10.1999)
Published in Journal of the American Chemical Society (13.10.1999)
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Journal Article
The Crystal Structure of a Pyrrolinone−Peptide Hybrid Ligand Bound to the Human Class II MHC Protein HLA-DR1
Lee, Kon Ho, Olson, Gary L, Bolin, David R, Benowitz, Andrew B, Sprengeler, Paul A, Smith, Amos B, Hirschmann, Ralph F, Wiley, Don C
Published in Journal of the American Chemical Society (06.09.2000)
Published in Journal of the American Chemical Society (06.09.2000)
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Journal Article
Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
Pappalardi, Melissa B, Keenan, Kathryn, Cockerill, Mark, Kellner, Wendy A, Stowell, Alexandra, Sherk, Christian, Wong, Kristen, Pathuri, Sarath, Briand, Jacques, Steidel, Michael, Chapman, Philip, Groy, Arthur, Wiseman, Ashley K, McHugh, Charles F, Campobasso, Nino, Graves, Alan P, Fairweather, Emma, Werner, Thilo, Raoof, Ali, Butlin, Roger J, Rueda, Lourdes, Horton, John R, Fosbenner, David T, Zhang, Cunyu, Handler, Jessica L, Muliaditan, Morris, Mebrahtu, Makda, Jaworski, Jon-Paul, McNulty, Dean E, Burt, Charlotte, Eberl, H Christian, Taylor, Amy N, Ho, Thau, Merrihew, Susan, Foley, Shawn W, Rutkowska, Anna, Li, Mei, Romeril, Stuart P, Goldberg, Kristin, Zhang, Xing, Kershaw, Christopher S, Bantscheff, Marcus, Jurewicz, Anthony J, Minthorn, Elisabeth, Grandi, Paola, Patel, Mehul, Benowitz, Andrew B, Mohammad, Helai P, Gilmartin, Aidan G, Prinjha, Rab K, Ogilvie, Donald, Carpenter, Christopher, Heerding, Dirk, Baylin, Stephen B, Jones, Peter A, Cheng, Xiaodong, King, Bryan W, Luengo, Juan I, Jordan, Allan M, Waddell, Ian, Kruger, Ryan G, McCabe, Michael T
Published in Nature cancer (01.10.2021)
Published in Nature cancer (01.10.2021)
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Journal Article