Hepatic Glucocorticoid Receptor Antagonism Is Sufficient to Reduce Elevated Hepatic Glucose Output and Improve Glucose Control in Animal Models of Type 2 Diabetes
Jacobson, Peer B, von Geldern, Thomas W, Ohman, Lars, Osterland, Marie, Wang, Jiahong, Zinker, Bradley, Wilcox, Denise, Nguyen, Phong T, Mika, Amanda, Fung, Steven, Fey, Thomas, Goos-Nilsson, Annika, Grynfarb, Marlena, Barkhem, Tomas, Marsh, Kennan, Beno, David W A, Nga-Nguyen, Bach, Kym, Philip R, Link, James T, Tu, Noah, Edgerton, Dale S, Cherrington, Alan, Efendic, Suad, Lane, Benjamin C, Opgenorth, Terry J
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
Published in The Journal of pharmacology and experimental therapeutics (01.07.2005)
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Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C
Published in Journal of medicinal chemistry (13.03.2003)
Published in Journal of medicinal chemistry (13.03.2003)
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Basal Insulin Degludec and Glycemic Control Compared to Aspart Via Insulin Pump in Type 1 Diabetes (BIGLEAP): A Single-Center, Open-Label, Randomized, Crossover Trial
Lane, Wendy S, Weinrib, Stephen L, Lawrence, Michael J, Lane, Benjamin C, Jarrett, Ryan T
Published in Endocrine practice (01.02.2022)
Published in Endocrine practice (01.02.2022)
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Nonsteroidal Selective Glucocorticoid Modulators: the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C
Published in Journal of medicinal chemistry (06.12.2001)
Published in Journal of medicinal chemistry (06.12.2001)
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Synthesis and Characterization of Non-Steroidal Ligands for the Glucocorticoid Receptor: Selective Quinoline Derivatives with Prednisolone-Equivalent Functional Activity
Coghlan, Michael J, Kym, Philip R, Elmore, Steven W, Wang, Alan X, Luly, Jay R, Wilcox, Denise, Stashko, Michael, Lin, Chun-Wei, Miner, Jeffrey, Tyree, Curtis, Nakane, Masaki, Jacobson, Peer, Lane, Benjamin C
Published in Journal of medicinal chemistry (30.08.2001)
Published in Journal of medicinal chemistry (30.08.2001)
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Rapamycin analogs with reduced systemic exposure
Wagner, Rolf, Mollison, Karl W., Liu, Luping, Henry, Cynthia L., Rosenberg, Teresa A., Bamaung, Nwe, Tu, Noah, Wiedeman, Paul E., Or, Yatsun, Luly, Jay R., Lane, Benjamin C., Trevillyan, James, Chen, Yung-Wu, Fey, Thomas, Hsieh, Gin, Marsh, Kennan, Nuss, Merrill, Jacobson, Peer B., Wilcox, Denise, Carlson, Richard P., Carter, George W., Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
Published in Bioorganic & medicinal chemistry letters (01.12.2005)
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32-Ascomycinyloxyacetic Acid Derived Immunosuppressants. Independence of Immunophilin Binding and Immunosuppressive Potency
Wagner, Rolf, Rhoades, Teresa A, Or, Yat Sun, Lane, Benjamin C, Hsieh, Gin, Mollison, Karl W, Luly, Jay R
Published in Journal of medicinal chemistry (21.05.1998)
Published in Journal of medicinal chemistry (21.05.1998)
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Retention of Immunosuppressant Activity in an Ascomycin Analogue Lacking a Hydrogen-Bonding Interaction with FKBP12
Wiedeman, Paul E, Fesik, Stephen W, Petros, Andrew M, Nettesheim, David G, Mollison, Karl W, Lane, Benjamin C, Or, Yat Sun, Luly, Jay R
Published in Journal of medicinal chemistry (21.10.1999)
Published in Journal of medicinal chemistry (21.10.1999)
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Structure-activity profiles of macrolactam immunosuppressant FK-506 analogues
Kawai, Megumi, Lane, Benjamin C., Hsieh, Gin C., Mollison, Karl W., Carter, George W., Luly, Jay R.
Published in FEBS letters (25.01.1993)
Published in FEBS letters (25.01.1993)
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A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases
MOLLISON, K. W, FEY, T. A, CANNON, J, MARSH, K, CARTER, G. W, OR, Y.-S, CHEN, Y.-W, HSIEH, G. C, LULY, J. R, GAUVIN, D. M, KOLANO, R. M, SHEETS, M. P, SMITH, M. L, PONG, M, NIKOLAIDIS, N. M, LANE, B. C, TREVILLYAN, J. M
Published in Journal of investigative dermatology (01.05.1999)
Published in Journal of investigative dermatology (01.05.1999)
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A Macrolactam Inhibitor of T Helper Type 1 and T Helper Type 2 Cytokine Biosynthesis for Topical Treatment of Inflammatory Skin Diseases1
Mollison, Karl W., Fey, Thomas A., Gauvin, Donna M., Kolano, Robin M., Sheets, Michael P., Smith, Morey L., Pong, Melissa, Nikolaidis, Nikolaos M., Lane, Benjamin C., Trevillyan, James M., Carter, George W., Or, Yat-Sun, Chen, Yung-Wu, Hsieh, Gin C., Cannon, John, Marsh, Kennan, Luly, Jay R.
Published in Journal of investigative dermatology (01.05.1999)
Published in Journal of investigative dermatology (01.05.1999)
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Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases
Mollison, K W, Fey, T A, Gauvin, D M, Sheets, M P, Smith, M L, Pong, M, Krause, R, Miller, L, Or, Y S, Kawai, M, Wagner, R, Wiedeman, P E, Clark, R F, Gunawardana, I W, Rhoades, T A, Henry, C L, Tu, N P, BaMaung, N Y, Kopecka, H, Liu, L, Xie, Q, Lane, B C, Trevillyan, J M, Marsh, K, Luly, J R
Published in Current pharmaceutical design (01.10.1998)
Published in Current pharmaceutical design (01.10.1998)
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Studies on an immunosuppressive macrolactam, ascomycin: Synthesis of a C-33 hydroxyl derivative
Kawai, Megumi, Gunawardana, Indrani W.K., Mollison, Karl W., Hsieh, Gin C., Lane, Benjamin C., Luly, Jay R.
Published in Bioorganic & medicinal chemistry letters (21.04.1998)
Published in Bioorganic & medicinal chemistry letters (21.04.1998)
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