Discovery of a Novel Amino Lipid That Improves Lipid Nanoparticle Performance through Specific Interactions with mRNA
Cornebise, Mark, Narayanan, Elisabeth, Xia, Yan, Acosta, Edward, Ci, Lei, Koch, Hillary, Milton, Jaclyn, Sabnis, Staci, Salerno, Timothy, Benenato, Kerry E.
Published in Advanced functional materials (01.02.2022)
Published in Advanced functional materials (01.02.2022)
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Journal Article
Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA
Patel, Siddharth, Ashwanikumar, N, Robinson, Emily, DuRoss, Allison, Sun, Conroy, Murphy-Benenato, Kerry E, Mihai, Cosmin, Almarsson, Örn, Sahay, Gaurav
Published in Nano letters (13.09.2017)
Published in Nano letters (13.09.2017)
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Journal Article
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Hassett, Kimberly J., Benenato, Kerry E., Jacquinet, Eric, Lee, Aisha, Woods, Angela, Yuzhakov, Olga, Himansu, Sunny, Deterling, Jessica, Geilich, Benjamin M., Ketova, Tatiana, Mihai, Cosmin, Lynn, Andy, McFadyen, Iain, Moore, Melissa J., Senn, Joseph J., Stanton, Matthew G., Almarsson, Örn, Ciaramella, Giuseppe, Brito, Luis A.
Published in Molecular therapy. Nucleic acids (15.04.2019)
Published in Molecular therapy. Nucleic acids (15.04.2019)
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Journal Article
Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates
Zhu, Xuling, Yin, Ling, Theisen, Matt, Zhuo, Jenny, Siddiqui, Summar, Levy, Becca, Presnyak, Vladimir, Frassetto, Andrea, Milton, Jaclyn, Salerno, Timothy, Benenato, Kerry E., Milano, Joe, Lynn, Andy, Sabnis, Staci, Burke, Kristine, Besin, Gilles, Lukacs, Christine M., Guey, Lin T., Finn, Patrick F., Martini, Paolo G.V.
Published in American journal of human genetics (04.04.2019)
Published in American journal of human genetics (04.04.2019)
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Journal Article
Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia
Jiang, Lei, Park, Ji-Sun, Yin, Ling, Laureano, Rodrigo, Jacquinet, Eric, Yang, Jinsong, Liang, Shi, Frassetto, Andrea, Zhuo, Jenny, Yan, Xinhua, Zhu, Xuling, Fortucci, Steven, Hoar, Kara, Mihai, Cosmin, Tunkey, Christopher, Presnyak, Vlad, Benenato, Kerry E., Lukacs, Christine M., Martini, Paolo G. V., Guey, Lin T.
Published in Nature communications (21.10.2020)
Published in Nature communications (21.10.2020)
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Journal Article
Systemic messenger RNA as an etiological treatment for acute intermittent porphyria
Jiang, Lei, Berraondo, Pedro, Jericó, Daniel, Guey, Lin T., Sampedro, Ana, Frassetto, Andrea, Benenato, Kerry E., Burke, Kristine, Santamaría, Eva, Alegre, Manuel, Pejenaute, Álvaro, Kalariya, Mayur, Butcher, William, Park, Ji-Sun, Zhu, Xuling, Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Kenney, Matthew, Lukacs, Christine M., Ávila, Matías A., Martini, Paolo G. V., Fontanellas, Antonio
Published in Nature medicine (01.12.2018)
Published in Nature medicine (01.12.2018)
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Journal Article
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.
Published in Cell reports (Cambridge) (19.12.2017)
Published in Cell reports (Cambridge) (19.12.2017)
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Journal Article
mRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency
Cao, Jingsong, An, Ding, Galduroz, Mikel, Zhuo, Jenny, Liang, Shi, Eybye, Marianne, Frassetto, Andrea, Kuroda, Eishi, Funahashi, Aki, Santana, Jordan, Mihai, Cosmin, Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Sabnis, Staci, Salerno, Timothy, Coughlan, Kimberly, Miracco, Edward J., Levy, Becca, Besin, Gilles, Schultz, Joshua, Lukacs, Christine, Guey, Lin, Finn, Patrick, Furukawa, Tatsuhiko, Giangrande, Paloma H., Saheki, Takeyori, Martini, Paolo G.V.
Published in Molecular therapy (03.07.2019)
Published in Molecular therapy (03.07.2019)
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Journal Article
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
Sabnis, Staci, Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Ketova, Tatiana, Senn, Joseph J., Lynn, Andy, Bulychev, Alex, McFadyen, Iain, Chan, Joyce, Almarsson, Örn, Stanton, Matthew G., Benenato, Kerry E.
Published in Molecular therapy (06.06.2018)
Published in Molecular therapy (06.06.2018)
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Journal Article
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy
Kim, Aryun, Kutschke, Amy, Ehmann, David E, Patey, Sara A, Crandon, Jared L, Gorseth, Elise, Miller, Alita A, McLaughlin, Robert E, Blinn, Christina M, Chen, April, Nayar, Asha S, Dangel, Brian, Tsai, Andy S, Rooney, Michael T, Murphy-Benenato, Kerry E, Eakin, Ann E, Nicolau, David P
Published in Antimicrobial agents and chemotherapy (01.12.2015)
Published in Antimicrobial agents and chemotherapy (01.12.2015)
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Accelerated Blood Clearance of Lipid Nanoparticles Entails a Biphasic Humoral Response of B-1 Followed by B-2 Lymphocytes to Distinct Antigenic Moieties
Besin, Gilles, Milton, Jaclyn, Sabnis, Staci, Howell, Rebecca, Mihai, Cosmin, Burke, Kristine, Benenato, Kerry E, Stanton, Matthew, Smith, Peter, Senn, Joseph, Hoge, Stephen
Published in ImmunoHorizons (01.07.2019)
Published in ImmunoHorizons (01.07.2019)
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Journal Article
Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
An, Ding, Schneller, Jessica L., Frassetto, Andrea, Liang, Shi, Zhu, Xuling, Park, Ji-Sun, Theisen, Matt, Hong, Sue-Jean, Zhou, Jenny, Rajendran, Raj, Levy, Becca, Howell, Rebecca, Besin, Gilles, Presnyak, Vladimir, Sabnis, Staci, Murphy-Benenato, Kerry E., Kumarasinghe, E. Sathyajith, Salerno, Timothy, Mihai, Cosmin, Lukacs, Christine M., Chandler, Randy J., Guey, Lin T., Venditti, Charles P., Martini, Paolo G.V.
Published in Cell reports (Cambridge) (28.08.2018)
Published in Cell reports (Cambridge) (28.08.2018)
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Journal Article
Discovery of Efficacious Pseudomonas aeruginosa-Targeted Siderophore-Conjugated Monocarbams by Application of a Semi-mechanistic Pharmacokinetic/Pharmacodynamic Model
Murphy-Benenato, Kerry E, Bhagunde, Pratik R, Chen, April, Davis, Hajnalka E, Durand-Réville, Thomas F, Ehmann, David E, Galullo, Vincent, Harris, Jennifer J, Hatoum-Mokdad, Holia, Jahić, Haris, Kim, Aryun, Manjunatha, M. R, Manyak, Erika L, Mueller, John, Patey, Sara, Quiroga, Olga, Rooney, Michael, Sha, Li, Shapiro, Adam B, Sylvester, Mark, Tan, Beesan, Tsai, Andy S, Uria-Nickelsen, Maria, Wu, Ye, Zambrowski, Mark, Zhao, Shannon X
Published in Journal of medicinal chemistry (12.03.2015)
Published in Journal of medicinal chemistry (12.03.2015)
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Journal Article
Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development
Murphy-Benenato, Kerry E., Gingipalli, Lakshmaiah, Boriack-Sjodin, P. Ann, Martinez-Botella, Gabriel, Carcanague, Dan, Eyermann, Charles J., Gowravaram, Madhu, Harang, Jenna, Hale, Michael R., Ioannidis, Georgine, Jahic, Harris, Johnstone, Michele, Kutschke, Amy, Laganas, Valerie A., Loch, James T., Miller, Matthew D., Oguto, Herbert, Patel, Sahil Joe
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
Published in Bioorganic & medicinal chemistry letters (15.11.2015)
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Journal Article
Synthesis, Structure, and SAR of Tetrahydropyran-Based LpxC Inhibitors
Murphy-Benenato, Kerry E, Olivier, Nelson, Choy, Allison, Ross, Philip L, Miller, Matthew D, Thresher, Jason, Gao, Ning, Hale, Michael R
Published in ACS medicinal chemistry letters (13.11.2014)
Published in ACS medicinal chemistry letters (13.11.2014)
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Journal Article
SAR and Structural Analysis of Siderophore-Conjugated Monocarbam Inhibitors of Pseudomonas aeruginosa PBP3
Murphy-Benenato, Kerry E, Dangel, Brian, Davis, Hajnalka E, Durand-Réville, Thomas F, Ferguson, Andrew D, Gao, Ning, Jahić, Haris, Mueller, John P, Manyak, Erika L, Quiroga, Olga, Rooney, Michael, Sha, Li, Sylvester, Mark, Wu, Frank, Zambrowski, Mark, Zhao, Shannon X
Published in ACS medicinal chemistry letters (14.05.2015)
Published in ACS medicinal chemistry letters (14.05.2015)
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Journal Article
Translating slow-binding inhibition kinetics into cellular and in vivo effects
Walkup, Grant K, You, Zhiping, Ross, Philip L, Allen, Eleanor K H, Daryaee, Fereidoon, Hale, Michael R, O'Donnell, John, Ehmann, David E, Schuck, Virna J A, Buurman, Ed T, Choy, Allison L, Hajec, Laurel, Murphy-Benenato, Kerry, Marone, Valerie, Patey, Sara A, Grosser, Lena A, Johnstone, Michele, Walker, Stephen G, Tonge, Peter J, Fisher, Stewart L
Published in Nature chemical biology (01.06.2015)
Published in Nature chemical biology (01.06.2015)
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