Search Results - "BENCSIK, JOSEF R" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

by Blake, James F, Xu, Rui, Bencsik, Josef R, Xiao, Dengming, Kallan, Nicholas C, Schlachter, Stephen, Mitchell, Ian S, Spencer, Keith L, Banka, Anna L, Wallace, Eli M, Gloor, Susan L, Martinson, Matthew, Woessner, Richard D, Vigers, Guy P.A, Brandhuber, Barbara J, Liang, Jun, Safina, Brian S, Li, Jun, Zhang, Birong, Chabot, Christine, Do, Steven, Lee, Leslie, Oeh, Jason, Sampath, Deepak, Lee, Brian B, Lin, Kui, Liederer, Bianca M, Skelton, Nicholas J
Published in Journal of medicinal chemistry (27.09.2012)

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Journal Article

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery of pyrrolopyrimidine inhibitors of Akt

by Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)

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Discovery and SAR of spirochromane Akt inhibitors

Discovery and SAR of spirochromane Akt inhibitors

by Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)

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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

by Bencsik, Josef R., Xiao, Dengming, Blake, James F., Kallan, Nicholas C., Mitchell, Ian S., Spencer, Keith L., Xu, Rui, Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Woessner, Richard D., Dizon, Faith, Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J., Prior, Wei Wei, Murray, Lesley J.
Published in Bioorganic & medicinal chemistry letters (01.12.2010)

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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators

by Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)

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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

by Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)

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Journal Article

Efficient, Stereoselective Synthesis of Oxazolo[3,2-a]pyrazin-5-ones: Novel Bicyclic Lactam Scaffolds from the Bicyclocondensation of 3-Aza-1,5-ketoacids and Amino Alcohols

Efficient, Stereoselective Synthesis of Oxazolo[3,2-a]pyrazin-5-ones: Novel Bicyclic Lactam Scaffolds from the Bicyclocondensation of 3-Aza-1,5-ketoacids and Amino Alcohols

by Bencsik, Josef R, Kercher, Timothy, O'Sulliva, Michael, Josey, John A
Published in Organic letters (24.07.2003)

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Journal Article

Enantioselective Synthesis of (−)-LL-C10037α from Benzoquinone

Enantioselective Synthesis of (−)-LL-C10037α from Benzoquinone

by Murphy, Sean T, Bencsik, Josef R, Johnson, Carl R
Published in Organic letters (04.11.1999)

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Journal Article

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by SPENCER KEITH L, MITCHELL IAN S, XU RUI, XIAO DENGMING, CHABOT CHRISTINE, BENCSIK JOSEF R, LIANG JUN, SAFINA BRIAN S, KALLAN NICHOLAS C, BLAKE JAMES F
Year of Publication 07.08.2015

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Patent

Diversification of the Three-Component Coupling of 2-Aminoheterocycles, Aldehydes, and Isonitriles: Efficient Parallel Synthesis of a Diverse and Druglike Library of Imidazo- and Tetrahydroimidazo[1,2-a] Heterocycles

Diversification of the Three-Component Coupling of 2-Aminoheterocycles, Aldehydes, and Isonitriles: Efficient Parallel Synthesis of a Diverse and Druglike Library of Imidazo- and Tetrahydroimidazo[1,2-a] Heterocycles

by Kercher, Timothy, Rao, Chang, Bencsik, Josef R, Josey, John A
Published in Journal of combinatorial chemistry (01.11.2007)

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Journal Article

5H-CYCLOPENTA[d]PYRIMIDINE AS AKT PROTEIN KINASE INHIBITOR

5H-CYCLOPENTA[d]PYRIMIDINE AS AKT PROTEIN KINASE INHIBITOR

by HENTEMANN MARTIN F, ANNA BANKA, BENCSIK JOSEF R, JAMES F BLAKE, LIANG JUN, STEPHEN T SCHLACHTER, RUI XU, IAN S MITCHELL, ELI M WALLACE, TONY P TANG, KALLEN NICHOLAS C
Year of Publication 15.01.2015

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Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 11.05.2015

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Patent

AKT-PROTEIN KINASE INHIBITOR HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINE

AKT-PROTEIN KINASE INHIBITOR HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINE

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, SPENCER KEITH LEE, RUI XU, WALLACE ELI W, KALLEN NICHOLAS C
Year of Publication 11.12.2014

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Patent

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS

by HINKLIN RONALD JAY, PRATT SCOTT ALAN, TURNER TIMOTHY M, FISCHER JOHN P, BENCSIK JOSEF R, FELL JAY BRADFORD, CONDROSKI KEVIN RONALD, AICHER THOMAS DANIEL, SINGH AJAY, BOYD STEVEN ARMEN
Year of Publication 06.09.2013

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Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 25.07.2014

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Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 26.12.2013

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Patent

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED CYCLOPENTA[D]PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS

by SCHLACHTER STEPHEN T, XIAO DENGMING, SAFINA BRIAN, BENCSIK JOSEF R, LIANG JUN, BANKA ANNA L, BLAKE JAMES F, MITCHELL IAN S, XU RUI, CHABOT CHRISTINE, ZHANG BIRONG, DO STEVEN, WALLACE ELI M, SPENCER KEITH LEE, KALLAN NICHOLAS C
Year of Publication 22.03.2013

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Patent

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by SPENCER KEITH L, MITCHELL IAN S, XU RUI, XIAO DENGMING, CHABOT CHRISTINE, BENCSIK JOSEF R, LIANG JUN, SAFINA BRIAN S, KALLAN NICHOLAS C, BLAKE JAMES F
Year of Publication 17.03.2010

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Patent

HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by MITCHELL IAN S, XU RUI, XIAO DENGMING, CHABOT CHRISTINE, SAFINA BRIAN, BENCSIK JOSEF R, DO STEVEN, ZHANG BIRONG, SPENCER KEITH LEE, LIANG JUN, KALLAN NICHOLAS C, BLAKE JAMES F
Year of Publication 04.11.2010

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Patent

HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS

by Leivers, Anna L, Bencsik, Josef R, Blake, James F, Safina, Brian, Schlachter, Stephen T, Chabot, Christine, Kallan, Nicholas C, Xu, Rui, Liang, Jun, Do, Steven, Xiao, Dengming, Zhang, Birong, Mitchell, Ian S, Spencer, Keith Lee, Wallace, Eli M
Year of Publication 21.07.2022

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Patent

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