protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9
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Published in The FASEB journal (01.09.2009)
Published in The FASEB journal (01.09.2009)
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Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes
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Published in The Journal of biological chemistry (04.09.2009)
Published in The Journal of biological chemistry (04.09.2009)
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Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
Jin, Lei, Galonek, Heidi, Israelian, Kristine, Choy, Wendy, Morrison, Michael, Xia, Yu, Wang, Xiaohong, Xu, Yihua, Yang, Yuecheng, Smith, Jesse J., Hoffmann, Ethan, Carney, David P., Perni, Robert B., Jirousek, Michael R., Bemis, Jean E., Milne, Jill C., Sinclair, David A., Westphal, Christoph H.
Published in Protein science (01.03.2009)
Published in Protein science (01.03.2009)
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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid
Vu, Chi B, Bemis, Jean E, Benson, Ericka, Bista, Pradeep, Carney, David, Fahrner, Richard, Lee, Diana, Liu, Feng, Lonkar, Pallavi, Milne, Jill C, Nichols, Andrew J, Picarella, Dominic, Shoelson, Adam, Smith, Jesse, Ting, Amal, Wensley, Allison, Yeager, Maisy, Zimmer, Michael, Jirousek, Michael R
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Discovery of oxazolo[4,5- b]pyridines and related heterocyclic analogs as novel SIRT1 activators
Bemis, Jean E., Vu, Chi B., Xie, Roger, Nunes, Joseph J., Ng, Pui Yee, Disch, Jeremy S., Milne, Jill C., Carney, David P., Lynch, Amy V., Jin, Lei, Smith, Jesse J., Lavu, Siva, Iffland, Andre, Jirousek, Michael R., Perni, Robert B.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
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Discovery of Imidazo[1,2-b]thiazole Derivatives as Novel SIRT1 Activators
Vu, Chi B, Bemis, Jean E, Disch, Jeremy S, Ng, Pui Yee, Nunes, Joseph J, Milne, Jill C, Carney, David P, Lynch, Amy V, Smith, Jesse J, Lavu, Siva, Lambert, Philip D, Gagne, David J, Jirousek, Michael R, Schenk, Simon, Olefsky, Jerrold M, Perni, Robert B
Published in Journal of medicinal chemistry (12.03.2009)
Published in Journal of medicinal chemistry (12.03.2009)
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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
Choy, Wendy, Sinclair, David A, Lambert, Philip D, Gagne, David J, Lynch, Amy V, Milne, Jill C, Bemis, Jean E, Boss, Olivier, Perni, Robert B, Schenk, Simon, Carney, David P, Yang, Hongying, Ng, Pui Yee, Iffland, Andre, Smith, Jesse J, Elliott, Peter J, Vu, Chi B, Xie, Roger, Galonek, Heidi, Israelian, Kristine, Lavu, Siva, Medvedik, Oliver, Olefsky, Jerrold M, Disch, Jeremy S, Nunes, Joseph J, Jirousek, Michael R, Westphal, Christoph H, Jin, Lei
Published in Nature (29.11.2007)
Published in Nature (29.11.2007)
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Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR
DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties
Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
Published in Bioorganic & medicinal chemistry letters (15.04.2007)
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Structure-Guided Design of Aminopyrimidine Amides as Potent, Selective Inhibitors of Lymphocyte Specific Kinase: Synthesis, Structure–Activity Relationships, and Inhibition of in Vivo T Cell Activation
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Chai, Lilly, Chaffee, Stuart C, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Gore, Anu, Gu, Yan, Henkle, Brad, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (27.03.2008)
Published in Journal of medicinal chemistry (27.03.2008)
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Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck: Synthesis, SAR, and in Vivo Anti-Inflammatory Activity
DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian
Published in Journal of medicinal chemistry (21.09.2006)
Published in Journal of medicinal chemistry (21.09.2006)
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Crystal Structures of Human SIRT[subscript 3] Displaying Substrate-induced Conformational Changes
Jin, Lei, Wei, Wentao, Jiang, Yaobin, Peng, Hao, Cai, Jianhua, Mao, Chen, Dai, Han, Choy, Wendy, Bemis, Jean E., Jirousek, Michael R., Milne, Jill C., Westphal, Christoph H., Perni, Robert B.
Published in The Journal of biological chemistry (04.11.2009)
Published in The Journal of biological chemistry (04.11.2009)
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Structure–activity relationships of indole cytosolic phospholipase A 2 α inhibitors: substrate mimetics
McKew, John C, Lovering, Frank, Clark, James D, Bemis, Jean, Xiang, YiBin, Shen, Marina, Zhang, Wen, Alvarez, Juan C, Joseph-McCarthy, Diane
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
Erratum to “Discovery of novel 2,3-diarylfuro[2,3- b]pyridin-4-amines as potent and selective inhibitors of Lck: Synthesis, SAR, and pharmacokinetic properties” [Bioorg. Med. Chem. Lett. 17 (2007) 2299–2304]
Martin, Matthew W., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., McGowan, David C., White, Ryan D., Buchanan, John L., DiMauro, Erin F., Boucher, Christina, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Schneider, Stephen, Turci, Susan M., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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SIRTUIN MODULATING THIAZOLOPYRIDINE COMPOUNDS
OALMANN CHRISTOPHER, VU CHI B, DISCH JEREMY S, NG PUI YEE, PERNI ROBERT B, BEMIS JEAN
Year of Publication 14.05.2010
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Year of Publication 14.05.2010
Patent
SIRTUIN MODULATING IMIDAZOTHIAZOLE COMPOUNDS
JIROUSEK MICHAEL, VU CHI B, DISCH JEREMY S, NG PUI YEE, BEMIS JEAN, LUNSMANN WALTER JOSEPH
Year of Publication 12.04.2010
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Year of Publication 12.04.2010
Patent
Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics
McKew, John C, Lovering, Frank, Clark, James D, Bemis, Jean, Xiang, YiBin, Shen, Marina, Zhang, Wen, Alvarez, Juan C, Joseph-McCarthy, Diane
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
Published in Bioorganic & medicinal chemistry letters (15.12.2003)
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Journal Article
Erratum to “Discovery of 4-amino-5,6-biaryl-furo[2,3- d]pyrimidines as inhibitors of Lck: Development of an expedient and divergent synthetic route and preliminary SAR” [Bioorg. Med. Chem. Lett. 17 (2007) 2305–2309]
DiMauro, Erin F., Newcomb, John, Nunes, Joseph J., Bemis, Jean E., Boucher, Christina, Buchanan, John L., Buckner, William H., Cheng, Alan, Faust, Theodore, Hsieh, Faye, Huang, Xin, Lee, Josie H., Marshall, Teresa L., Martin, Matthew W., McGowan, David C., Schneider, Stephen, Turci, Susan M., White, Ryan D., Zhu, Xiaotian
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
Published in Bioorganic & medicinal chemistry letters (15.09.2007)
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Journal Article