Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts
Lexa, Katrina W, Belyk, Kevin M, Henle, Jeremy, Xiang, Bangping, Sheridan, Robert P, Denmark, Scott E, Ruck, Rebecca T, Sherer, Edward C
Published in Organic process research & development (18.03.2022)
Published in Organic process research & development (18.03.2022)
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Journal Article
Enantioselective Synthesis of 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) via Enzymatic Desymmetrization
McLaughlin, Mark, Kong, Jongrock, Belyk, Kevin M, Chen, Billy, Gibson, Andrew W, Keen, Stephen P, Lieberman, David R, Milczek, Erika M, Moore, Jeffrey C, Murray, David, Peng, Feng, Qi, Ji, Reamer, Robert A, Song, Zhiguo J, Tan, Lushi, Wang, Lin, Williams, Michael J
Published in Organic letters (17.02.2017)
Published in Organic letters (17.02.2017)
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Journal Article
A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions
Ji, Yining, Li, Hongming, Hyde, Alan M., Chen, Qinghao, Belyk, Kevin M., Lexa, Katrina W., Yin, Jingjun, Sherer, Edward C., Williamson, R. Thomas, Brunskill, Andrew, Ren, Sumei, Campeau, Louis-Charles, Davies, Ian W., Ruck, Rebecca T.
Published in Chemical science (Cambridge) (01.04.2017)
Published in Chemical science (Cambridge) (01.04.2017)
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Journal Article
Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester
Belyk, Kevin M, Xiang, Bangping, Bulger, Paul G, Leonard, William R, Balsells, Jaume, Yin, Jingjun, Chen, Cheng-yi
Published in Organic process research & development (21.05.2010)
Published in Organic process research & development (21.05.2010)
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Journal Article
Enantioselective Synthesis of N‑Benzylic Heterocycles by Ni/Photoredox Dual Catalysis
Lacker, Caitlin R., DeLano, Travis J., Chen, Emily P., Kong, Jongrock, Belyk, Kevin M., Piou, Tiffany, Reisman, Sarah E.
Published in Journal of the American Chemical Society (09.11.2022)
Published in Journal of the American Chemical Society (09.11.2022)
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Journal Article
Enantio- and Diastereoselective Total Synthesis of Belzutifan Enabled by Rh-Catalyzed Hydrogenation
Le, Diane N., Johnson, Heather C., Lam, Yu-hong, Sun, Chunrui, Cheng, Lili, Belyk, Kevin M.
Published in Organic letters (17.05.2024)
Published in Organic letters (17.05.2024)
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Journal Article
Late‐Stage Modification of Oligopeptides by Nickel‐Catalyzed Stereoselective Radical Addition to Dehydroalanine
Qi, Xiaoxu, Jambu, Subramanian, Ji, Yining, Belyk, Kevin M., Panigrahi, Nihar R., Arora, Paramjit S., Strotman, Neil A., Diao, Tianning
Published in Angewandte Chemie International Edition (25.11.2022)
Published in Angewandte Chemie International Edition (25.11.2022)
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Journal Article
Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides
Li, Hongming, Belyk, Kevin M, Yin, Jingjun, Chen, Qinghao, Hyde, Alan, Ji, Yining, Oliver, Steven, Tudge, Matthew T, Campeau, Louis-Charles, Campos, Kevin R
Published in Journal of the American Chemical Society (04.11.2015)
Published in Journal of the American Chemical Society (04.11.2015)
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Journal Article
Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib
Chung, Cheol K, Bulger, Paul G, Kosjek, Birgit, Belyk, Kevin M, Rivera, Nelo, Scott, Mark E, Humphrey, Guy R, Limanto, John, Bachert, Donald C, Emerson, Khateeta M
Published in Organic process research & development (17.01.2014)
Published in Organic process research & development (17.01.2014)
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Journal Article
Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts
Xiang, Bangping, Belyk, Kevin M., Reamer, Robert A., Yasuda, Nobuyoshi
Published in Angewandte Chemie (04.08.2014)
Published in Angewandte Chemie (04.08.2014)
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Journal Article
Late‐Stage Modification of Oligopeptides by Nickel‐Catalyzed Stereoselective Radical Addition to Dehydroalanine
Qi, Xiaoxu, Jambu, Subramanian, Ji, Yining, Belyk, Kevin M., Panigrahi, Nihar R., Arora, Paramjit S., Strotman, Neil A., Diao, Tianning
Published in Angewandte Chemie (25.11.2022)
Published in Angewandte Chemie (25.11.2022)
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Journal Article
Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle
Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M
Published in Journal of organic chemistry (07.10.2011)
Published in Journal of organic chemistry (07.10.2011)
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Journal Article
Synthesis of α-Hydroxyacetophenones
McLaughlin, Mark, Belyk, Kevin M, Qian, Gang, Reamer, Robert A, Chen, Cheng-yi
Published in Journal of organic chemistry (01.06.2012)
Published in Journal of organic chemistry (01.06.2012)
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Journal Article
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
Humphrey, Guy R, Pye, Philip J, Zhong, Yong-Li, Angelaud, Remy, Askin, David, Belyk, Kevin M, Maligres, Peter E, Mancheno, Danny E, Miller, Ross A, Reamer, Robert A, Weissman, Steven A
Published in Organic process research & development (21.01.2011)
Published in Organic process research & development (21.01.2011)
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Journal Article
Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain
Chobanian, Harry R, Guo, Yan, Liu, Ping, Chioda, Marc D, Fung, Selena, Lanza, Thomas J, Chang, Linda, Bakshi, Raman K, Dellureficio, James P, Hong, Qingmei, McLaughlin, Mark, Belyk, Kevin M, Krska, Shane W, Makarewicz, Amanda K, Martel, Elliot J, Leone, Joseph F, Frey, Lisa, Karanam, Bindhu, Madeira, Maria, Alvaro, Raul, Shuman, Joyce, Salituro, Gino, Terebetski, Jenna L, Jochnowitz, Nina, Mistry, Shruti, McGowan, Erin, Hajdu, Richard, Rosenbach, Mark, Abbadie, Catherine, Alexander, Jessica P, Shiao, Lin-Lin, Sullivan, Kathleen M, Nargund, Ravi P, Wyvratt, Matthew J, Lin, Linus S, DeVita, Robert J
Published in ACS medicinal chemistry letters (12.06.2014)
Published in ACS medicinal chemistry letters (12.06.2014)
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Journal Article
CGRP PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS
BELYK KEVIN M, YASUDA NOBUYOSHI, KUO SHEN CHUN, XIANG BANGPING, CLEATOR EDWARD, YIN JIANGUO, MALIGRES PETER EMMANUEL
Year of Publication 23.01.2024
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Year of Publication 23.01.2024
Patent
Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0
Leonard, William R, Belyk, Kevin M, Conlon, David A, Bender, Dean R, DiMichele, Lisa M, Liu, Ji, Hughes, David L
Published in Journal of organic chemistry (30.03.2007)
Published in Journal of organic chemistry (30.03.2007)
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Journal Article
Correction to Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle
Song, Zhiguo J, Tellers, David M, Journet, Michel, Kuethe, Jeffrey T, Lieberman, David, Humphrey, Guy, Zhang, Fei, Peng, Zhihui, Waters, Marjorie S, Zewge, Daniel, Nolting, Andrew, Zhao, Dalian, Reamer, Robert A, Dormer, Peter G, Belyk, Kevin M, Davies, Ian W, Devine, Paul N, Tschaen, David M
Published in Journal of organic chemistry (18.11.2011)
Published in Journal of organic chemistry (18.11.2011)
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Journal Article
CGRP PROCESS FOR MAKING CGRP RECEPTOR ANTAGONISTS
BELYK KEVIN M, YASUDA NOBUYOSHI, KUO SHEN CHUN, XIANG BANGPING, CLEATOR EDWARD, YIN JIANGUO, MALIGRES PETER EMMANUEL
Year of Publication 13.12.2022
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Year of Publication 13.12.2022
Patent