Tau accumulation in degradative organelles is associated to lysosomal stress
Piovesana, Ester, Magrin, Claudia, Ciccaldo, Matteo, Sola, Martina, Bellotto, Manolo, Molinari, Maurizio, Papin, Stéphanie, Paganetti, Paolo
Published in Scientific reports (21.10.2023)
Published in Scientific reports (21.10.2023)
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Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type I
Cubero, Elena, Ruano, Ana, Delgado, Aida, Barril, Xavier, Morales, Sara, Trapero, Ana, Leoni, Lorenzo, Bellotto, Manolo, Maj, Roberto, Guzmán, Beatriz Calvo-Flores, Pérez-Carmona, Natalia, Garcia-Collazo, Ana Maria
Published in PloS one (20.05.2024)
Published in PloS one (20.05.2024)
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Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors
Rudinskiy, Mikhail, Pons-Vizcarra, Maria, Soldà, Tatiana, Fregno, Ilaria, Bergmann, Timothy Jan, Ruano, Ana, Delgado, Aida, Morales, Sara, Barril, Xavier, Bellotto, Manolo, Cubero, Elena, García-Collazo, Ana María, Pérez-Carmona, Natalia, Molinari, Maurizio
Published in PloS one (29.11.2023)
Published in PloS one (29.11.2023)
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Journal Article
Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal
Chamoun, Zeina, Mann, Randall K., Nellen, Denise, von Kessler, Doris P., Bellotto, Manolo, Beachy, Philip A., Basler, Konrad
Published in Science (American Association for the Advancement of Science) (14.09.2001)
Published in Science (American Association for the Advancement of Science) (14.09.2001)
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Journal Article
A structurally targeted allosteric regulator of GCase restores enzyme activity, reduces microgliosis, and improves fine locomotor skills in the CBE model of neuronopathic Gaucher disease
Guzman, Beatriz, Pérez, Natalia, Garcia-Collazo, Ana Maria, Cubero, Elena, Barril, Xavier, Bellotto, Manolo, Taylor, Joanne
Published in Molecular genetics and metabolism (01.02.2023)
Published in Molecular genetics and metabolism (01.02.2023)
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Journal Article
Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric [beta]-Galactosidase correctors
Rudinskiy, Mikhail, Pons-Vizcarra, Maria, Soldà, Tatiana, Fregno, Ilaria, Bergmann, Timothy Jan, Ruano, Ana, Delgado, Aida, Morales, Sara, Barril, Xavier, Bellotto, Manolo, Cubero, Elena, García-Collazo, Ana María, Pérez-Carmona, Natalia, Molinari, Maurizio
Published in PloS one (29.11.2023)
Published in PloS one (29.11.2023)
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Journal Article
Brain penetrant structurally targeted allosteric regulators for treating GLB1-related disorders
Bellotto, Manolo, Maj, Roberto, García-Collazo, Ana María, Ruano, Ana, Delgado, Aida, Morales, Sara, Cubero, Elena, Pérez-Carmona, Natalia, Barril, Xavier
Published in Molecular genetics and metabolism (01.02.2020)
Published in Molecular genetics and metabolism (01.02.2020)
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아릴 및 헤테로아릴 화합물, 및 갈락토세레브로시다제의 활성 변경과 관련된 병태에서의 치료 용도
GARCIA COLLAZO ANA MARIA, BARRIL ALONSO XAVIER, CUBERO JORDA ELENA, BELLOTTO MANOLO
Year of Publication 11.11.2022
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Year of Publication 11.11.2022
Patent
헤테로아릴 화합물 및 베타-글루코세레브로시다제의 활성의 변경과 관련된 병태에서의 이의 치료적 용도
FERNANDEZ IGLESIAS ENRIQUE, GARCIA COLLAZO ANA MARIA, CUBERO JORDA ELENA, BELLOTTO MANOLO
Year of Publication 11.11.2022
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Year of Publication 11.11.2022
Patent
Dispatched, a Novel Sterol-Sensing Domain Protein Dedicated to the Release of Cholesterol-Modified Hedgehog from Signaling Cells
Burke, Richard, Nellen, Denise, Bellotto, Manolo, Hafen, Ernst, Senti, Kirsten-André, Dickson, Barry J., Basler, Konrad
Published in Cell (23.12.1999)
Published in Cell (23.12.1999)
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